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Experiences, Exposures, and Alzheimer’s Disease: Longitudinal Study of Olfaction, Cognition, and Metabolism in Older US Adults (NSHAP EXPOSOME)

Award Number: R01AG100240
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2031

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Experiences, Exposures, and Alzheimer’s Disease: Longitudinal Study of Olfaction, Cognition, and Metabolism in Older US Adults (NSHAP EXPOSOME) - PROJECT ABSTRACT Exposure to environmental hazards contributes to Alzheimer’s Disease and Related Dementias (AD/ADRD), but the underlying mechanisms that connect them are unknown. Once we better understand how the chemical, biological, physical, and social influences that constitute the ‘exposome’ affect the development of AD/ADRD, we can identify related biological mechanisms and social factors involved in AD/ADRD and design interventions that will improve the health and function of millions of people worldwide. In this project, we take advantage of the upcoming Round 5 data collection of the National Social Life, Health, and Aging Project (NSHAP), a nationally representative, longitudinal study that focuses on the links between social, physical/mental, and cognitive health trajectories among older US adults. Enriching NSHAP with detailed environmental exposure information and additional biological samples offers enormous potential for advancing AD/ADRD research. Here we will collect residential address histories on all NSHAP respondents, assign long term air pollution exposures, and collect direct measures of other airborne exposures (indoor air pollution and volatile organic chemicals). We will perform metabolomic analyses on blood samples to determine biological pathways that connect airborne exposures to cognitive decline and AD/ADRD. Finally, we will link the address histories to relevant public datasets and use NSHAP’s rich data to understand the role of social environment in exposure and disease. Analyses of these intersecting pathways will identify pharmacologic targets and nonpharmacologic interventions that could mitigate adverse neurologic consequences. Close relationships between NSHAP and i) other major cohort studies of aging and ii) national exposome initiatives allow us to harmonize measures, facilitate data sharing, and spark productive collaborations, benefiting the scientific community. Thus, this project will have a significant, sustained impact on the AD/ADRD field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,460,509 )
2026	2026	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Aging Research	000	1	6/26/2026	NEW	$1,460,509
														Subtotal = $1,460,509

Grand Total All Awards = $1,460,509

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Experiences, Exposures, and Alzheimer’s Disease: Longitudinal Study of Olfaction, Cognition, and Metabolism in Older US Adults (NSHAP EXPOSOME)

Award Number: R01AG100240

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2031

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