Friday, July 4, 2025 7/4/2025

Mitochondrial DNA Compaction and the Accumulation of Mutations with Age and Stress

Award Number: R01AG092732
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/17/2025
PERIOD OF PERFORMANCE END DATE: 04/30/2030

Group Awards By:

View Award Description

Mitochondrial DNA Compaction and the Accumulation of Mutations with Age and Stress - PROJECT SUMMARY/ABSTRACT The primary goal of this project is to understand the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA (mtDNA) mutations, which build up over an individual’s lifetime due to ongoing replication and oxidative stress. Because these mutations can cause or exacerbate cellular aging, this work has implications for the prevention and treatment of age-related degenerative diseases. The study will utilize innovative long-read sequencing approaches to quantify accessibility, mutations, and various types of damage all along individual mtDNA molecules. Mechanistic work in cultured human cells will quantify the role of mtDNA compaction in protection against mutations from various pharmacological, genetic, and environmental stressors as well as define the temporal dynamics of mtDNA architecture at single molecule resolution. Work in vivo will seek to define the consistency of mtDNA form across cell type and age. Together, these approaches will offer a comprehensive understanding of how mtDNA compaction influences mutation rates and mitochondrial health, potentially unveiling new avenues for therapeutic intervention to mitigate aging and related diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $793,777 )
2025	2025	J.DAVID GLADSTONE INSTITUTES	1650 OWENS ST	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	Aging Research	000	1	6/17/2025	NEW	$793,777
														Subtotal = $793,777

Grand Total All Awards = $793,777

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Mitochondrial DNA Compaction and the Accumulation of Mutations with Age and Stress

Award Number: R01AG092732

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/17/2025

PERIOD OF PERFORMANCE END DATE: 04/30/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer