Monday, August 18, 2025 8/18/2025

Novel oxidative pathway targets microglia in Alzheimer's disease

Award Number: R01AG082382
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Novel oxidative pathway targets microglia in Alzheimer's disease - Abstract Alzheimer's disease is the most common dementia characterized by progressive cognitive decline. By estimates, Alzheimer's disease affects more than one-third of the population over 85, posing a substantial socioeconomic burden. There is an apparent lack of understanding of the molecular mechanisms of Alzheimer's disease and reported problems with animal models. These obstacles prevent the development of new therapeutic strategies, especially their translation to human patients. This proposal is based on molecular and cellular evidence and an analysis of human Alzheimer's disease cases. It bridges several aspects of Alzheimer's disease pathology: discovery of unique oxidative stress pathway, new aspects of microglial biology and dysfunction, and basic mechanisms of cell adhesion/phagocytosis in the context of disease. We will answer how exactly oxidation causes microglial dysfunction in Alzheimer's disease and how to prevent/inhibit their detrimental consequences. Based on our pioneering preliminary studies, we propose that oxidative stress targets important proteins in microglia responsible for phagocytosis, leading to deficient phagocytosis and microglia overactivation in Alzheimer's disease. Therefore, we will focus on the mechanisms of this damage and its prevention in Alzheimer's disease and other neurodegenerative pathologies. We will develop a new intervention approach (compounds neutralizing oxidative stress) and uncover new specific targets for the treatment of Alzheimer's disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $767,342 )
2025	2025	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY	9500 EUCLID AVE.	CLEVELAND	OH	44195	CUYAHOGA	USA	Aging Research	001	2	6/20/2025	NON-COMPETING CONTINUATION	$62,640
2025	2025	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY	9500 EUCLID AVE.	CLEVELAND	OH	44195	CUYAHOGA	USA	Aging Research	000	2	4/21/2025	NON-COMPETING CONTINUATION	$704,702
														Subtotal = $767,342

Issue Date FY: 2024 ( Subtotal = $783,003 )
2024	2024	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY	9500 EUCLID AVE.	CLEVELAND	OH	44195	CUYAHOGA	USA	Aging Research	000	1	8/2/2024	NEW	$783,003
														Subtotal = $783,003

Grand Total All Awards = $1,550,345

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Novel oxidative pathway targets microglia in Alzheimer's disease

Award Number: R01AG082382

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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