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Efficient IBD mapping for Alzheimer's Disease and related brain imaging phenotypes

Award Number: R01AG081398
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Efficient IBD mapping for Alzheimer's Disease and related brain imaging phenotypes - PROJECT SUMMARY/ABSTRACT Alzheimer’s Disease (AD) is a highly heritable complex human disease, but only a limited number of its genetic risk factors have been identified. In this project, we propose to leverage identical-by-descent (IBD) segments, which are expected to better tag haplotype effects and provide complementary genetic information to additively coded genotypes that are commonly used in genome-wide association studies, in the genetic association mapping for AD and related brain imaging endophenotypes. In Aim 1, we will develop the statistical and computational framework for efficient genetic association mapping using IBD segments in large samples. In Aim 2, we will apply IBD mapping to identify novel genomic regions associated with brain imaging endophenotypes from the UK Biobank. In Aim 3, we will replicate these associations in the Alzheimer’s Disease Sequencing Project (ADSP), develop and apply IBD mapping methods to AD, and combine association evidence from diverse populations in the UK Biobank and ADSP. Our novel tools and findings from this project will be made publicly available to facilitate novel discoveries that improve our understanding on the genetic architecture of AD and related brain imaging data.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $737,056 )
2025	2025	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Aging Research	002	2	7/21/2025	NON-COMPETING CONTINUATION	$737,056
2025	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Aging Research	001	1	12/6/2024	NEW	$746,792
2025	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Aging Research	000	1	12/4/2024	NEW	-$746,792
														Subtotal = $737,056

Issue Date FY: 2024 ( Subtotal = $746,792 )
2024	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Aging Research	001	1	9/23/2024	NEW	$0
2024	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Aging Research	000	1	9/20/2024	NEW	$746,792
														Subtotal = $746,792

Grand Total All Awards = $1,483,848

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Efficient IBD mapping for Alzheimer's Disease and related brain imaging phenotypes

Award Number: R01AG081398

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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