Wednesday, December 4, 2024 12/4/2024

Characterizing sleep brain dynamics associated with Alzheimer's disease pathology and progression in humans using EEG source localization and PET

Award Number: R01AG080678
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Alzheimer’s disease (AD) is a neurodegenerative disease that is the most common cause of dementia. AD encompasses a range of pathophysiologic processes including accumulation of amyloid-beta, neurofibrillary tau tangles, neuronal degeneration, and neuroinflammation. There is now strong evidence suggesting that changes in brain dynamics during sleep are related to development of underlying neuropathology. Previous studies have examined correlations between scalp EEG features and coarse summary measures of PET amyloid and tau, but the more precise link between neural electrophysiology and amyloid/tau pathology at site-, region-, and network-levels has not yet been analyzed in detail. Characterizing these spatially and functionally specific patterns is critical for future early detection of AD using sleep-related biomarkers, development of sleep interventions to slow disease progression, and electrophysiological monitoring of amyloid/tau-centric treatments. Meanwhile, over the past several years, our group has made significant advances in EEG source localization methods that enable localization of cerebral currents in cortical and subcortical regions at a resolution that is comparable to PET and fMRI. In this project, we propose to measure high-density EEG during sleep in humans, alongside PET and MRI, across the stages of AD from Preclinical to Mild Cognitive Impairment to mild AD dementia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,503,957 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	000	3	11/27/2024	NON-COMPETING CONTINUATION	$1,503,957
														Subtotal = $1,503,957

Issue Date FY: 2024 ( Subtotal = $1,686,029 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	001	2	4/18/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,686,029
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	003	2	7/16/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,025,662
2024	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Aging Research	000	1	4/17/2024	NEW	$0
2024	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Aging Research	002	1	7/16/2024	NEW	-$1,025,662
														Subtotal = $1,686,029

Issue Date FY: 2023 ( Subtotal = $1,871,738 )
2023	2023	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Aging Research	000	1	12/14/2022	NEW	$1,871,738
														Subtotal = $1,871,738

Grand Total All Awards = $5,061,724

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Characterizing sleep brain dynamics associated with Alzheimer's disease pathology and progression in humans using EEG source localization and PET

Award Number: R01AG080678

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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