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Perceived Control and Cognitive Aging: Pathways to Preserve Cognitive Functioning and Reduce Risk of Alzheimer’s Disease in Socioeconomically Diverse Populations

Award Number: R01AG075117
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Perceived Control and Cognitive Aging: Pathways to Preserve Cognitive Functioning and Reduce Risk of Alzheimer’s Disease in Socioeconomically Diverse Populations - PROJECT SUMMARY/ABSTRACT The number of Americans with Alzheimer’s disease-related dementias will nearly triple by 2060 without major scientific advances in knowledge of modifiable factors that can be targeted using interventions. One modifiable psychological resource linked to the preservation of cognitive functioning involves the beliefs people hold about their ability to influence important outcomes in their lives (perceived control). However, little is known about how (mechanistic pathways) perceived control protects against short-term and long-term declines in cognitive functioning or whether its protective influence differs across populations that vary in risk of cognitive decline due to disparities in socioeconomic resources. These critical knowledge gaps are due to limitations in prior research that has largely focused on establishing main effect associations between perceived control and cognitive functioning over either very brief (one-week) or very extended (multi-year) time windows. In this new investigator application, we will address these problems using a real-world, contextual approach to systematically assess how and under which conditions perceived control buffers against declines in cognition across multiple time- scales (days, months, years). We will pursue the following specific aims: 1) identify the motivation, emotion, and health behavior change processes that mediate the association between perceived control and multi-timescale changes in cognitive functioning; 2) determine the extent to which the association between perceived control and multi-timescale changes in cognitive functioning is more pronounced for middle-aged and older adults with limited socioeconomic resources. We will pursue these aims using an innovative approach that generates new micro-longitudinal data and also leverages pre-existing macro-longitudinal data. New micro-longitudinal data will be collected on dynamic daily and monthly changes in perceived control, motivation, emotion, health behaviors, and cognitive functioning in a regional sample of 200 middle-aged and older adults (4 weekly bursts over 1.5 years). Pre-existing macro-longitudinal data on 9-year changes in the same measures will be obtained from the national Midlife in the United States study. This unique approach permits a systematic analysis of the mediated (Aim 1) and moderated (Aim 2) pathways linking perceived control to changes in cognition that unfold over days, months, and years. The proposed research will address the urgent need to identify modifiable psychological and behavioral factors underlying socioeconomic disparities in cognitive aging and the timescales (days, months, years) at which these factors have their strongest influence. This knowledge will inform evidence-based approaches on when (at which timescale) it is most effective to target changes in psychobehavioral resources to preserve cognitive functioning for populations at increased risk of Alzheimer’s disease-related dementias.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $363,294 )
2025	2025	NORTH DAKOTA STATE UNIVERSITY	1340 ADMINISTRATION AVE	FARGO	ND	58105	CASS	USA	Aging Research	000	4	7/15/2025	NON-COMPETING CONTINUATION	$363,294
														Subtotal = $363,294

Issue Date FY: 2024 ( Subtotal = $469,235 )
2024	2024	NORTH DAKOTA STATE UNIVERSITY	1301 12TH AVE N	FARGO	ND	58102	CASS	USA	Aging Research	000	3	6/6/2024	NON-COMPETING CONTINUATION	$469,235
														Subtotal = $469,235

Issue Date FY: 2023 ( Subtotal = $474,121 )
2023	2023	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Aging Research	000	2	6/5/2023	NON-COMPETING CONTINUATION	$474,121
														Subtotal = $474,121

Issue Date FY: 2022 ( Subtotal = $405,329 )
2022	2022	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Aging Research	001	1	9/2/2022	NEW	$0
2022	2022	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Aging Research	000	1	8/19/2022	NEW	$405,329
														Subtotal = $405,329

Grand Total All Awards = $1,711,979

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Perceived Control and Cognitive Aging: Pathways to Preserve Cognitive Functioning and Reduce Risk of Alzheimer’s Disease in Socioeconomically Diverse Populations

Award Number: R01AG075117

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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