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Liposomal Encapsulation Vaccine Design for Pneumococcal Disease in Aged Subjects

Award Number: R01AG074990
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/04/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Liposomal Encapsulation Vaccine Design for Pneumococcal Disease in Aged Subjects - PROJECT SUMMARY Pneumococcal disease has a disproportional impact upon the young and elderly. Notably, advanced age and influenza A virus infection act synergistically to enhance susceptibility to pneumococcal lung infections. Indeed, older adults (>65 years old) account for 70-85% of deaths due to the combination of influenza and pneumonia. As this vulnerable population is projected to reach two billion worldwide by 2050, novel preventative approaches that boost resistance to secondary pneumococcal pneumonia, and pneumococcal disease more generally, are needed. Background: The Pfeifer group has engineered a novel vaccine formulation, termed Liposomal Encapsulation of Polysaccharides (LEPS), designed to account for both the breadth of Streptococcus pneumoniae bacterial serotypes and the unique progression profiles that complicate treatment options for pneumococcal disease. Significance/Innovation: The LEPS formulation combines both polysaccharide and protein antigens, which is an innovative approach that provides both capsule specific immunity and cross protection against other serotypes and stages of disease progression. Because this vaccine candidate has matched and exceeded the capabilities of Prevnar-13 in normal-aged mice, the enclosed application features a complementary collaboration with Dr. Elsa Bou Ghanem to test the Hypothesis that vaccination of elderly mice with the LEPS particle will induce a robust immune response relative to current pneumococcal vaccine formulations. This hypothesis will be thoroughly addressed through three specific Aims: 1) Expand Serotype Coverage with the LEPS Platform in Pneumonia Models using Aged Mice with Detailed Immunological Assessment to Reveal Mechanism; 2) Assess Secondary Bacterial Pneumonia within Aged Mice using the LEPS Platform; and 3) Test Intranasal Delivery of LEPS Formulations for Pneumococcal Disease in Mice across Age. Host survival, clinical disease score, organ-specific bacterial burden, and other indicators of infection severity (organ pathology) will be measured over time across vaccine and non-vaccine pneumococcal strains to assess serotype-specific protection as well as cross protection. Successful outcomes will include treatment effectiveness beyond current vaccine options (i.e., PPSV and PCV), in which case, we will have important preclinical data needed to support translational progression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $404,408 )
2026	2026	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Aging Research	000	5	4/9/2026	NON-COMPETING CONTINUATION	$404,408
														Subtotal = $404,408

Issue Date FY: 2025 ( Subtotal = $396,319 )
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Aging Research	001	4	6/18/2025	NON-COMPETING CONTINUATION	$32,351
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Aging Research	000	4	4/10/2025	NON-COMPETING CONTINUATION	$363,968
														Subtotal = $396,319

Issue Date FY: 2024 ( Subtotal = $404,206 )
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Aging Research	000	3	5/2/2024	NON-COMPETING CONTINUATION	$404,206
														Subtotal = $404,206

Issue Date FY: 2023 ( Subtotal = $402,990 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Aging Research	000	2	5/2/2023	NON-COMPETING CONTINUATION	$402,990
														Subtotal = $402,990

Issue Date FY: 2022 ( Subtotal = $399,353 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Aging Research	000	1	8/3/2022	NEW	$399,353
														Subtotal = $399,353

Grand Total All Awards = $2,007,276

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Liposomal Encapsulation Vaccine Design for Pneumococcal Disease in Aged Subjects

Award Number: R01AG074990

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/04/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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