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Novel Neuromodulation Treatment of Age Related Vestibular Loss to Improve Balance and Gait in Elderly Individuals

Award Number: R01AG073161
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Novel Neuromodulation Treatment of Age Related Vestibular Loss to Improve Balance and Gait in Elderly Individuals - Abstract Loss of neural function is a common problem with aging and disease. To treat this loss, current neural stimulators have used various forms of stimulation that putatively activate neurons to elicit neuromodulation. Generally these stimulators rely on a fixed frequency and amplitude stimulus. Recently, we have found that subperceptual levels of random electrical stimulation applied to the vestibular system produce improvements in vestibular-mediated reflex function, balance and gait demonstrating the use of low levels of electrical stimulation to enhance the natural neural signaling of the vestibular system without exogenous stimulus. The goal of this present work is to demonstrate the sustained improvement of balance and gait by applying low levels of random electrical stimulation to the vestibular system of elderly individuals with vestibular hypofunction. We hypothesize that elderly participants will display functional improvement with sustained low levels of random electrical stimulation. This work will establish parameters for viable treatment of age related vestibular loss in elderly individuals using safe and effective amounts of electrical stimulation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Aging Research	002	4	2/12/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$561,102
2025	2023	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	001	3	2/12/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$561,102
2025	2023	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	000	3	11/26/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $537,052 )
2024	2024	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Aging Research	002	4	9/3/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$537,052
2024	2023	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	001	3	12/5/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$424,341
2024	2022	RUTGERS, THE STATE UNIVERSITY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	000	2	12/5/2023	NON-COMPETING CONTINUATION	-$424,341
														Subtotal = $537,052

Issue Date FY: 2023 ( Subtotal = $498,974 )
2023	2023	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	000	3	7/5/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$498,974
2023	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	001	2	8/29/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $498,974

Issue Date FY: 2022 ( Subtotal = $500,930 )
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	002	2	7/8/2022	NON-COMPETING CONTINUATION	$500,930
2022	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	001	1	2/10/2022	NEW	$0
2022	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	000	1	1/19/2022	NEW	$0
														Subtotal = $500,930

Issue Date FY: 2021 ( Subtotal = $546,181 )
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	000	1	9/23/2021	NEW	$546,181
														Subtotal = $546,181

Grand Total All Awards = $2,083,137

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Novel Neuromodulation Treatment of Age Related Vestibular Loss to Improve Balance and Gait in Elderly Individuals

Award Number: R01AG073161

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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