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Chronic Alcohol Exposure and Pathophysiology of Alzheimer's Disease.

Award Number: R01AG072898
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Chronic Alcohol Exposure and Pathophysiology of Alzheimer's Disease. - Project Summary Repeated and excessive alcohol consumption is known to lead to brain damage, and may increase the risk of developing Alzheimer’s Disease (AD). A recent study demonstrated that light-to-moderate alcohol consumption, as low as eight drinks a week, may be associated with cognitive decline and AD. Not surprisingly, alcohol consumption appears to be more harmful to the elderly. Since alcohol metabolism rates decline with age, it could have a greater effect and may exacerbate underlying cognitive problems. However, the limitation of these epidemiological studies includes their observational nature without a mechanistic investigation of the “cause and effect” on how alcohol may impact the AD development. Importantly, it is widely known that women are approximately twice as likely to develop AD. However, genetic and biological basis of the sex specific differences in AD is understudied. Therefore, it is essential to understand to what extent alcohol could exacerbate the development of AD depending on the starting age of alcohol consumption, sex, and genetic risk factors. Based on the in-depth expertise in alcohol use disorder (AUD) (Dr. Choi) and AD (Dr. Trushina), two PIs propose to conduct a collaborative research applying comprehensive approach to address these fundamental questions. Using two mouse models representing familial AD (APP/PS1) and late-onset sporadic AD (ApoE4KI), we will examine whether alcohol exposure has sex and/or age-dependent effect exacerbating the onset and development of AD in at-risk individuals. To investigate this hypothesis, we propose two specific aims. In the first aim, we will determine whether chronic alcohol exposure exacerbates AD-like behavioral and metabolic phenotype in APP/PS1 and ApoE4KI mouse models. In the second aim, we will determine the impact of chronic alcohol exposure on the pathophysiology and biomarkers of AD. The outcomes will be significant providing comprehensive data and critical biological evidence to establish the preclinical criteria and provide translatable information regarding the impact of alcohol on AD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Aging Research	000	5	12/2/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $397,500 )
2024	2024	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Aging Research	000	5	5/7/2024	NON-COMPETING CONTINUATION	$397,500
														Subtotal = $397,500

Issue Date FY: 2023 ( Subtotal = $397,500 )
2023	2023	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Aging Research	000	4	5/10/2023	NON-COMPETING CONTINUATION	$397,500
														Subtotal = $397,500

Issue Date FY: 2022 ( Subtotal = $397,500 )
2022	2022	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Aging Research	000	3	5/20/2022	NON-COMPETING CONTINUATION	$397,500
														Subtotal = $397,500

Issue Date FY: 2021 ( Subtotal = $397,500 )
2021	2021	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Aging Research	001	2	6/4/2021	NON-COMPETING CONTINUATION	$397,500
2021	2020	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Aging Research	000	1	10/29/2020	NEW	$0
														Subtotal = $397,500

Issue Date FY: 2020 ( Subtotal = $397,500 )
2020	2020	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Aging Research	000	1	9/17/2020	NEW	$397,500
														Subtotal = $397,500

Grand Total All Awards = $1,987,500

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Chronic Alcohol Exposure and Pathophysiology of Alzheimer's Disease.

Award Number: R01AG072898

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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