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Cross Sectional and Longitudinal Racial Disparity in Molecular Biomarkers of Alzheimer Disease

Award Number: R01AG067505
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Cross Sectional and Longitudinal Racial Disparity in Molecular Biomarkers of Alzheimer Disease - Currently, almost all molecular biomarker studies in Alzheimer disease (AD) and clinical trials on AD have been largely limited to Caucasian participants. The fundamental question is whether AD, as currently defined, is the same disease for African Americans, the largest under-represented group (URG) in the US, and Caucasians, both in the preclinical and symptomatic stages. Conflicting results have thus far appeared in the literature about this very question, largely due to the limited sample sizes of African Americans in published studies. We propose to tackle these problems by implementing a multi-center and longitudinal study with a central and standardized re-processing of all currently existing and prospectively collected cerebrospinal fluid (CSF) samples, magnetic resonance imaging (MRI) structural scans, and positron emission tomography (PET) beta-amyloid and PET tau imaging scans, in addition to a harmonization of clinical and cognitive outcomes. We will join forces with five major biomarker studies of AD: the Washington University Knight Alzheimer Disease Research Center (ADRC), University of Pennsylvania AD Core Center, Emory University ADRC, Harvard Aging Brain Study, and the Anti- Amyloid Treatment in Asymptomatic Alzheimer's trial. We will assemble likely the largest biomarker data set of African Americans, and analyze resulting AD biomarker and cognitive data in a comprehensive manner to examine the racial disparity in both the preclinical and the symptomatic stages. We will further assess the roles that AD risk factors, APOE ε4 status, family history, age, sex, education, socioeconomic status, and vascular burden play in cross sectional and longitudinal differences between African Americans and Caucasians. We will also determine the racial differences in the predictability of AD biomarkers to concurrent and longitudinal cognitive outcomes. These racial differences, if confirmed by the proposed study on the largest African Americans biomarker cohort, may imply potentially differential treatment responses between the races, and hence will have profound implications to the design and analyses of ongoing and future prevention and treatment trials of AD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	5	3/6/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $3,036,612 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Aging Research	000	5	5/7/2024	NON-COMPETING CONTINUATION	$3,036,612
														Subtotal = $3,036,612

Issue Date FY: 2023 ( Subtotal = $2,874,828 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	4	3/28/2023	NON-COMPETING CONTINUATION	$2,874,828
														Subtotal = $2,874,828

Issue Date FY: 2022 ( Subtotal = $2,706,678 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	3	4/6/2022	NON-COMPETING CONTINUATION	$2,706,678
														Subtotal = $2,706,678

Issue Date FY: 2021 ( Subtotal = $3,034,099 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	2	4/12/2021	NON-COMPETING CONTINUATION	$3,034,099
														Subtotal = $3,034,099

Issue Date FY: 2020 ( Subtotal = $3,024,874 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	1	5/28/2020	NEW	$3,024,874
														Subtotal = $3,024,874

Grand Total All Awards = $14,677,091

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Cross Sectional and Longitudinal Racial Disparity in Molecular Biomarkers of Alzheimer Disease

Award Number: R01AG067505

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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