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Arterial stiffness, brain morphology, cognition, and dementia in U.S. Hispanics/Latinos

Award Number: R01AG061088
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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Arterial stiffness, brain morphology, cognition, and dementia in U.S. Hispanics/Latinos - Cognitive impairment and Alzheimer's disease and related dementias (ADRD) are pressing public health concerns as the population ages. In the U.S., Hispanics/Latinos have a higher MCI and ADRD risk compared with other population groups, and they are expected to contribute disproportionately to the expected increase in mild cognitive impairment (MCI) and ADRD. Factors explaining this disparity are unknown. Higher central arterial stiffness is posited to alter microvasculature structure and function in the brain contributing to cerebral small vessel disease and with cognitive impairment and risk of ADRD in older white and black adults. No reports to date have examined these associations in a large, diverse Hispanic/Latino population. Similarly, the important roles of sex, obesity, the metabolic syndrome, and type 2 diabetes in these associations have not been assessed. U.S. Hispanics/Latinos have a high burden of cardiometabolic risk factors that are associated with both greater arterial stiffness and risk of ADRD and could contribute to the health disparity in MCI and ADRD. We propose to address these gaps in an ancillary study to the 2019-2022 Visit 3 examination of ~9,297 participants in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), an ongoing cohort study of well-characterized U.S. Hispanic/Latinos. We propose to add pulse wave velocity, a non-invasive arterial stiffness measurement, to participants ≥45 years old during Visit 3 (n ~7,020). All other data will be available from HCHS/SOL and its two ancillary studies. The Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) will provide data on cognitive performance and MCI and dementia classification for cohort members ≥45 years old at Visit 3 (~6,272). INCA-MRI will provide brain magnetic resonance imaging (MRI) data on a sample of cohort members (2017-2019, n ~2,800). The study aims are the following: Aim 1. Estimate the association of central arterial stiffness and cerebral small vessel disease (cerebral white matter hyperintensities, white matter integrity, and infarcts) overall and by sex. Aim 2. Estimate the association of central arterial stiffness and domain-specific cognitive function overall and by sex in participants ≥45 years old. Aim 3. Estimate the association of central arterial stiffness and MCI and ADRD overall and by sex in participants ≥45 years old. For all aims, we will evaluate obesity, the metabolic syndrome, and type 2 diabetes as potential modifiers. This cost-efficient ancillary study will, for the first time, contribute novel information on the association of central arterial stiffness and brain structure and function in a large sample of Hispanic/Latinos, a population burdened with a high levels of metabolic impairments. Additionally, the inclusion of middle-aged adults will provide insights into opportunities for early intervention prior to onset of overt disease. Understanding how arterial stiffness influences cognitive impairment and ADRD will contribute novel information on identifying potential targets for intervention, reducing health disparities, and the promoting cognitive resilience.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$15,930 )
2026	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Aging Research	000	4	3/31/2026	NON-COMPETING CONTINUATION	-$15,930
														Subtotal = -$15,930

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Aging Research	000	4	11/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Aging Research	000	4	12/29/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $736,359 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Aging Research	000	4	11/30/2021	NON-COMPETING CONTINUATION	$662,722
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Aging Research	001	4	4/21/2022	NON-COMPETING CONTINUATION	$73,637
														Subtotal = $736,359

Issue Date FY: 2021 ( Subtotal = $757,150 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Aging Research	000	3	12/14/2020	NON-COMPETING CONTINUATION	$681,435
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Aging Research	001	3	2/11/2021	NON-COMPETING CONTINUATION	$75,715
														Subtotal = $757,150

Issue Date FY: 2020 ( Subtotal = $669,446 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Aging Research	001	2	2/11/2020	NON-COMPETING CONTINUATION	$669,446
2020	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Aging Research	000	1	12/30/2019	NEW	$0
														Subtotal = $669,446

Issue Date FY: 2019 ( Subtotal = $799,664 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Aging Research	000	1	2/8/2019	NEW	$799,664
														Subtotal = $799,664

Grand Total All Awards = $2,946,689

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Arterial stiffness, brain morphology, cognition, and dementia in U.S. Hispanics/Latinos

Award Number: R01AG061088

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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