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Role of methylation-dependent pathways in aging and stress

Award Number: R01AG053355
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2017
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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Role of methylation-dependent pathways in aging and stress - Metabolic cycles provide building blocks and energy currency for the cell, but also signaling molecules that regulate diverse physiological responses from differentiation to aging. The metabolite S-adenosylmethionine (SAM) is one such factor that is used to regulate gene expression in the stress response, a key part of the aging process. We have discovered that individual SAM synthases has distinct effects and hypothesize that uncovering the mechanisms regulating local production of SAM will produce novel insights into stress-responses and aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $613,602 )
2026	2026	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	000	9	5/6/2026	NON-COMPETING CONTINUATION	$613,602
														Subtotal = $613,602

Issue Date FY: 2025 ( Subtotal = $601,329 )
2025	2025	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	001	8	6/10/2025	NON-COMPETING CONTINUATION	$49,088
2025	2025	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	000	8	5/2/2025	NON-COMPETING CONTINUATION	$552,241
														Subtotal = $601,329

Issue Date FY: 2024 ( Subtotal = $613,602 )
2024	2024	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	002	7	6/11/2024	NON-COMPETING CONTINUATION	$613,602
2024	2023	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	001	6	4/26/2024	COMPETING CONTINUATION	$401
2024	2021	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	000	5	4/26/2024	NON-COMPETING CONTINUATION	-$401
														Subtotal = $613,602

Issue Date FY: 2023 ( Subtotal = $630,477 )
2023	2023	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	000	6	8/17/2023	COMPETING CONTINUATION	$630,477
														Subtotal = $630,477

Issue Date FY: 2021 ( Subtotal = $405,171 )
2021	2021	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE NORTH	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	000	5	6/3/2021	NON-COMPETING CONTINUATION	$405,171
														Subtotal = $405,171

Issue Date FY: 2020 ( Subtotal = $405,171 )
2020	2020	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE NORTH	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	000	4	5/27/2020	NON-COMPETING CONTINUATION	$405,171
														Subtotal = $405,171

Issue Date FY: 2019 ( Subtotal = $414,841 )
2019	2019	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE NORTH	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	000	3	4/30/2019	NON-COMPETING CONTINUATION	$414,841
														Subtotal = $414,841

Issue Date FY: 2018 ( Subtotal = $414,841 )
2018	2018	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	000	2	5/1/2018	NON-COMPETING CONTINUATION	$414,841
														Subtotal = $414,841

Issue Date FY: 2017 ( Subtotal = $414,841 )
2017	2017	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Aging Research	000	1	8/17/2017	NEW	$414,841
														Subtotal = $414,841

Grand Total All Awards = $4,513,875

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Role of methylation-dependent pathways in aging and stress

Award Number: R01AG053355

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2017

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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