Wednesday, July 2, 2025 7/2/2025

The Hypothalamic Basis of Aging

Award Number: R01AG031774
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2010
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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The Hypothalamic Basis of Aging - ABSTRACT/SUMMARY Aging is multifaceted while many hormonal and metabolic regulators are crucial, pointing to the extremely strong significance of endocrine and metabolic processes in aging physiology and intervention. The hypothalamus is the “headquarters” for regulating systemic endocrine systems and metabolic physiology as well as the autonomic nervous system for physiological homeostasis. In the past, the lab of the PI has developed a major research area of studying the significance of hypothalamus in aging, including formulation of the “hypothalamic control of aging” paradigm which subsequently led to the generation of anti-aging model by hypothalamic stem/progenitor cells. The long-term objective of this research is to study the underlying hypothalamic anti-aging basis and therefore to develop novel and effective targets for counteracting against aging-related neurodegeneration and disease. In preliminary studies of this project, it was found that hypothalamic extracellular vesicles (EVs) are strongly anti-aging and anti-neurodegenerative in multiple experimental models. Also, parathymosin in these EVs was found crucial for the anti-neurodegenerative actions in recipient neurons. Thus, this project is proposed based on the hypothesis that hypothalamic EVs are important for brain transfer and neuroprotective while restoring these EVs has a significant interventional value against aging-related neurodegeneration and disorders. Three specific aims are: (1) study hypothalamic and brain transfer of hypothalamic EVs and aging relevance; (2) study the neuroprotective and anti- neurodegenerative actions of parathymosin-containing hypothalamic EVs and the underlying basis; (3) study the significance of hypothalamic EVs for treating neurodegenerative disorders and improving aging physiology and healthspan. Experiments in these Aims will be carried out by using mouse models of hypothalamic regional and cell-specific manipulations of EVs as well as models of pharmacological intervention with hypothalamic EVs. A list of molecular, cellular and physiological methods will be used to analyze hypothalamic EVs in terms of biochemical profile of brain distribution and uptake, the cellular effects for neuroprotection in recipient neurons, and anti-aging physiological and therapeutic effects in relevant aging models. Overall, successful completion of this project will lead to new important knowledge about the hypothalamic basis of aging and novel strategy for managing healthy aging and alleviating aging-related disorders and diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $560,788 )
2025	2025	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	001	15	6/20/2025	NON-COMPETING CONTINUATION	$45,778
2025	2025	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	15	4/21/2025	NON-COMPETING CONTINUATION	$515,010
														Subtotal = $560,788

Issue Date FY: 2024 ( Subtotal = $579,289 )
2024	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	14	6/4/2024	NON-COMPETING CONTINUATION	$579,289
														Subtotal = $579,289

Issue Date FY: 2023 ( Subtotal = $572,233 )
2023	2023	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	13	8/24/2023	COMPETING CONTINUATION	$572,233
														Subtotal = $572,233

Issue Date FY: 2022 ( Subtotal = -$418 )
2022	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	12	5/13/2022	NON-COMPETING CONTINUATION	-$418
														Subtotal = -$418

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	12	1/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $488,188 )
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	004	12	3/19/2019	NON-COMPETING CONTINUATION	$488,188
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	003	11	3/15/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$154,061
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	005	12	3/23/2019	NON-COMPETING CONTINUATION	$0
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	007	11	7/22/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$13,136
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	001	12	2/21/2019	NON-COMPETING CONTINUATION	-$488,188
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	12	12/28/2018	NON-COMPETING CONTINUATION	$488,188
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	006	10	7/22/2019	NON-COMPETING CONTINUATION	-$13,136
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	002	10	3/14/2019	NON-COMPETING CONTINUATION	-$154,061
														Subtotal = $488,188

Issue Date FY: 2018 ( Subtotal = $488,188 )
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	001	10	4/19/2018	NON-COMPETING CONTINUATION	$48,820
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	10	1/23/2018	NON-COMPETING CONTINUATION	$439,368
														Subtotal = $488,188

Issue Date FY: 2017 ( Subtotal = $488,188 )
2017	2017	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	001	9	6/15/2017	NON-COMPETING CONTINUATION	$48,820
2017	2017	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	9	12/23/2016	NON-COMPETING CONTINUATION	$439,368
														Subtotal = $488,188

Issue Date FY: 2016 ( Subtotal = $488,188 )
2016	2016	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Aging Research	000	8	1/29/2016	NON-COMPETING CONTINUATION	$488,188
2016	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Aging Research	001	7	2/22/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$64,630
2016	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	002	6	2/23/2016	COMPETING CONTINUATION	$64,630
														Subtotal = $488,188

Issue Date FY: 2015 ( Subtotal = $488,188 )
2015	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Aging Research	002	7	9/22/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$402,014
2015	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	001	6	9/21/2015	COMPETING CONTINUATION	-$402,014
2015	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	000	6	1/9/2015	COMPETING CONTINUATION	$488,188
														Subtotal = $488,188

Issue Date FY: 2014 ( Subtotal = $327,096 )
2014	2014	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	000	5	1/23/2014	NON-COMPETING CONTINUATION	$294,386
2014	2014	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	001	5	2/19/2014	NON-COMPETING CONTINUATION	$32,710
														Subtotal = $327,096

Issue Date FY: 2013 ( Subtotal = $309,105 )
2013	2013	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	001	4	5/17/2013	NON-COMPETING CONTINUATION	$14,719
2013	2013	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	000	4	1/15/2013	NON-COMPETING CONTINUATION	$294,386
														Subtotal = $309,105

Issue Date FY: 2012 ( Subtotal = $327,096 )
2012	2012	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	000	3	2/8/2012	NON-COMPETING CONTINUATION	$327,096
														Subtotal = $327,096

Issue Date FY: 2011 ( Subtotal = $327,096 )
2011	2011	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	001	2	6/21/2011	NON-COMPETING CONTINUATION	$20,826
2011	2011	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	000	2	2/2/2011	NON-COMPETING CONTINUATION	$306,270
														Subtotal = $327,096

Issue Date FY: 2010 ( Subtotal = $340,300 )
2010	2010	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	000	1	1/29/2010	NEW	$340,300
														Subtotal = $340,300

Grand Total All Awards = $5,783,525

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The Hypothalamic Basis of Aging

Award Number: R01AG031774

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2010

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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