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WEIGHT LOSS AND EXERCISE IN FRAIL OBESE ELDERLY SUBJECTS

Award Number: R01AG025501
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2005
PERIOD OF PERFORMANCE END DATE: 12/31/2013

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WEIGHT LOSS AND EXERCISE IN FRAIL OBESE ELDERLY SUBJECTS - Abstract: Obesity causes serious medical complications and impairs quality of life. Moreover, in elderly persons, obesity can lead to frailty by exacerbating the decline in strength, endurance, balance and mobility associated with aging and physical inactivity. Appropriate treatment for obesity in elderly persons is controversial because of the decreased relative health risks with increasing body mass index in the elderly and the potential harmful effects of weight loss on bone health and muscle mass. The primary objectives of the proposed research are to evaluate the independent and combined effects of weight loss and exercise on physical function, body composition, bone and muscle metabolism, and quality of life in frail, obese elderly men and women. The central hypothesis is that in frail obese elderly subjects, weight loss will improve physical function and quality of life, while the addition of exercise will not only augment improvement in these outcomes, but also attenuate the adverse effects of weight loss on bone and muscle masses. To test this hypothesis, 100 elderly (65-85 years old) obese men and women (BMI > 30 kg/m2) with physical frailty will be randomized to 4 treatment groups: 1) control, 2) 10% weight loss, 3) exercise training, and 4) 10% weight loss plus exercise training. Measures of physical function (physical performance test, performance-based tests of strength, flexibility, endurance, balance, and motor control, and questionnaires that evaluate functional status), body composition (total body fat and fat-free mass evaluated by dual energy x-ray absorptiometry, abdominal fat and thigh muscle mass measured by magnetic resonance imaging), bone mineral density (BMD) and bone turnover (total body and regional BMD in conjunction with markers of bone formation and resorption), muscle protein synthesis (myofibrillar protein synthesis rate using stable isotope tracer techniques), and health related quality-of-life (Short-Form Health Survey and Impact of Weight on Quality of Life questionnaires) will be determined before, during, and after a 52-week treatment intervention. Subjects randomized to weight loss and weight loss plus exercise group will participate in a comprehensive weight management program at the Washington University Weight Management Center. Subjects randomized to exercise or weight loss plus exercise will participate in a supervised exercise-training program (90-min sessions, 3 days/week for 52 weeks). Encouraging results from a 1-year pilot study suggest the feasibility and efficacy of a lifestyle modification program towards improving physical function in frail obese elderly subjects. The data generated from this proposed randomized controlled trial will ultimately establish appropriate treatment guidelines for the increasing number of frail obese elderly men and women.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2009	BIOMEDICAL RESEARCH INSTITUTE OF NEW MEXICO	1501 SAN PEDRO SOUTHEAST 151	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Aging Research	000	6	2/7/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2009	BIOMEDICAL RESEARCH INSTITUTE OF NEW MEXICO	1501 SAN PEDRO SOUTHEAST 151	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Aging Research	000	6	11/16/2011	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2009	BIOMEDICAL RESEARCH INSTITUTE OF NEW MEXICO	1501 SAN PEDRO SOUTHEAST 151	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Aging Research	000	6	11/9/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	5	1/14/2010	NON-COMPETING CONTINUATION	-$250,800
2010	2009	BIOMEDICAL RESEARCH INSTITUTE OF NEW MEXICO	1501 SAN PEDRO SOUTHEAST 151	ALBUQUERQUE	NM	87108	BERNALILLO	USA	Aging Research	000	6	1/14/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$250,800
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $359,737 )
2009	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	5	3/26/2009	NON-COMPETING CONTINUATION	$359,737
														Subtotal = $359,737

Issue Date FY: 2008 ( Subtotal = $356,440 )
2008	2008	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	4	2/20/2008	NON-COMPETING CONTINUATION	$356,440
														Subtotal = $356,440

Issue Date FY: 2007 ( Subtotal = $360,934 )
2007	2007	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	3	2/27/2007	NON-COMPETING CONTINUATION	$290,143
2007	2007	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	3	9/13/2007	SUPPLEMENT FOR EXPANSION	$70,791
														Subtotal = $360,934

Issue Date FY: 2006 ( Subtotal = $298,809 )
2006	2006	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	2	2/23/2006	NON-COMPETING CONTINUATION	$298,809
														Subtotal = $298,809

Issue Date FY: 2005 ( Subtotal = $306,000 )
2005	2005	WASHINGTON UNIVERSITY	7425 FORSYTH	CLAYTON	MO	63105	SAINT LOUIS	USA	Aging Research	000	1	12/31/2004	NEW	$306,000
														Subtotal = $306,000

Grand Total All Awards = $1,681,920

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WEIGHT LOSS AND EXERCISE IN FRAIL OBESE ELDERLY SUBJECTS

Award Number: R01AG025501

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2005

PERIOD OF PERFORMANCE END DATE: 12/31/2013

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