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Monitoring real-world driver behavior for classification and early prediction of Alzheimer’s disease

Award Number: R01AG017177
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/1999
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Monitoring real-world driver behavior for classification and early prediction of Alzheimer’s disease - This research project tackles the NIH/NIA grand challenge of using a person's own vehicle as a passive-detection system for flagging potential age- and disease-related aberrant driving that may signal early warning signs of functional decline or incipient Alzheimer's disease (AD). Early identification and treatment are essential steps to mitigating the growing costs and burden of AD. Our foundational advancements in quantifying driver behavior from in-vehicle systems ( Black Boxes ) and wearable sensors, and strategic analytic methods and pipelines using statistical and machine learning approaches, are directly relevant to meeting this NIH/NIA challenge. The proposal builds strategically on current project discoveries and successes that comprehensively characterized patterns of real-world driving exposure and risk in 136 older drivers across 500,000 miles driven. Under the proposal's conceptual framework, functional abilities determine specific driver behavior patterns and errors. Behaviors, in tum, index driver functional abilities and clinical features of NIA-Alzheimer's Association (AA) core clinical criteria of mild cognitive impairment (MCI) and AD (operationalized by Alzheimer's clinical syndrome [ACS]). Sleep and mobility play roles as key mediators of relationships between driver behavior and functional impairment. Accordingly, our Specific Aims (SA) are: SA1) Extract key real-world driver behavior features over a continuous, 3-month, baseline period that classify normally aging, MCI, and ACS drivers by NIA-AA core clinical criteria. SA2) Determine the extent to which real-world driver sleep and mobility factors, collected over a continuous, 3-month baseline period, mediate the relationship between extracted driver behavior and clinical features (SA1). SA3) Develop models (statistical and supervised machine learning) that combine features of driver behavior (SA 1) and real-world sleep and mobility (SA2) to detect clinical feature severity of MCI and AD and predict disease progression. To address these aims, our team of experts-in medicine, AD, driving in aging and disease, cognitive neuroscience, transportation engineering, machine learning, computer vision, and longitudinal biostatistics--will apply our approach to drivers with a broader range of impairments across the aging to AD spectrum. A total of 180 drivers, ages 65- 90 years, who have ACS (N=40), MCI (N=80), or are normally aging (N=60) based on NIA-AA clinical criteria will be studied across a 3-month baseline period of real-world naturalistic driver behavior, sleep, and mobility monitoring. Two longitudinal assessments, each 1 year apart, will comprehensively assess each driver's risk for and severity of functional decline. By extracting digital fingerprints of aberrant driver behavior in drivers al risk for AD, this project complements seismic advances in biologic diagnosis of preclinical AD and advances NIH priorities lo improve older driver safely, mobility, quality of life, with unprecedented access lo diagnostic care. Passive monitoring of real-world behavior to predict clinical status in individuals at risk for AD directly promotes interventions aimed at early treatment of and preventing progression of AD in its preclinical stages.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	4215 EMILE ST	OMAHA	NE	68105	DOUGLAS	USA	Aging Research	000	19	12/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	4215 EMILE ST	OMAHA	NE	68105	DOUGLAS	USA	Aging Research	000	19	1/24/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $960,603 )
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	000	19	2/26/2024	NON-COMPETING CONTINUATION	$864,543
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	001	19	6/28/2024	NON-COMPETING CONTINUATION	$96,060
														Subtotal = $960,603

Issue Date FY: 2023 ( Subtotal = $981,996 )
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	000	18	2/3/2023	NON-COMPETING CONTINUATION	$981,996
														Subtotal = $981,996

Issue Date FY: 2022 ( Subtotal = $1,041,035 )
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	000	17	4/7/2022	NON-COMPETING CONTINUATION	$1,041,035
														Subtotal = $1,041,035

Issue Date FY: 2021 ( Subtotal = $1,039,678 )
2021	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	004	16	3/25/2021	NON-COMPETING CONTINUATION	$1,039,678
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	007	15	6/28/2021	COMPETING CONTINUATION	-$240,095
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	003	15	3/18/2021	COMPETING CONTINUATION	$0
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	010	15	8/30/2021	COMPETING CONTINUATION	$240,095
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	002	15	3/12/2021	COMPETING CONTINUATION	$240,095
2021	2017	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	005	14	6/28/2021	NON-COMPETING CONTINUATION	$124,501
2021	2017	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	006	14	6/28/2021	SUPPLEMENT FOR EXPANSION	$115,594
2021	2017	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	000	14	3/12/2021	NON-COMPETING CONTINUATION	-$124,501
2021	2017	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	008	14	8/30/2021	NON-COMPETING CONTINUATION	-$124,501
2021	2017	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	001	14	3/12/2021	SUPPLEMENT FOR EXPANSION	-$115,594
2021	2017	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	009	14	8/30/2021	SUPPLEMENT FOR EXPANSION	-$115,594
														Subtotal = $1,039,678

Issue Date FY: 2020 ( Subtotal = $954,904 )
2020	2020	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	000	15	5/8/2020	COMPETING CONTINUATION	$813,746
2020	2020	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	001	15	6/1/2020	COMPETING CONTINUATION	$141,158
														Subtotal = $954,904

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	000	14	6/12/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $620,955 )
2017	2017	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	001	14	9/7/2017	SUPPLEMENT FOR EXPANSION	$115,594
2017	2017	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	000	14	6/14/2017	NON-COMPETING CONTINUATION	$505,361
														Subtotal = $620,955

Issue Date FY: 2016 ( Subtotal = $534,833 )
2016	2016	UNIVERSITY OF NEBRASKA MEDICAL CENTER	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	000	13	6/2/2016	NON-COMPETING CONTINUATION	$534,833
														Subtotal = $534,833

Issue Date FY: 2015 ( Subtotal = $535,645 )
2015	2015	UNIVERSITY OF NEBRASKA MEDICAL CENTER	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	002	12	5/18/2015	NON-COMPETING CONTINUATION	$535,645
2015	2014	UNIVERSITY OF NEBRASKA MEDICAL CENTER	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Aging Research	001	11	3/24/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$568,142
2015	2014	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Aging Research	000	10	3/23/2015	NON-COMPETING CONTINUATION	-$568,142
														Subtotal = $535,645

Issue Date FY: 2014 ( Subtotal = $568,142 )
2014	2014	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Aging Research	000	10	5/31/2014	NON-COMPETING CONTINUATION	$568,142
														Subtotal = $568,142

Issue Date FY: 2013 ( Subtotal = $605,309 )
2013	2013	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Aging Research	000	9	5/17/2013	COMPETING CONTINUATION	$605,309
														Subtotal = $605,309

Issue Date FY: 2010 ( Subtotal = $282,993 )
2010	2010	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Aging Research	000	8	6/16/2010	NON-COMPETING CONTINUATION	$282,993
														Subtotal = $282,993

Issue Date FY: 2009 ( Subtotal = $278,823 )
2009	2009	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Aging Research	000	7	7/3/2009	NON-COMPETING CONTINUATION	$278,823
														Subtotal = $278,823

Issue Date FY: 2008 ( Subtotal = $272,099 )
2008	2008	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Aging Research	000	6	6/4/2008	NON-COMPETING CONTINUATION	$272,099
														Subtotal = $272,099

Issue Date FY: 2007 ( Subtotal = $270,995 )
2007	2007	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Aging Research	000	5	7/13/2007	NON-COMPETING CONTINUATION	$270,995
														Subtotal = $270,995

Issue Date FY: 2006 ( Subtotal = $272,430 ) (Continued on the next page)
Grand Total All Awards = $10,218,332

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Monitoring real-world driver behavior for classification and early prediction of Alzheimer’s disease

Award Number: R01AG017177

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/1999

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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