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Longitudinal Study of Recovery: Psychosocial Functioning, Relapse, and Neuro-Behavioral Markers

Award Number: R01AA029135
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Longitudinal Study of Recovery: Psychosocial Functioning, Relapse, and Neuro-Behavioral Markers - PROJECT SUMMARY Alcohol use disorder (AUD) research typically analyzes relapse and recovery processes over short time-frames, such as during and immediately following a treatment episode. The long-term trajectories of recovery, the impact of relapse episodes, and their associated neurobehavioral markers and precipitants comprise a vital gap in our scientific understanding of the recovery process. Our goals are to provide a scientific understanding of recovery and relapse, as well as to identify novel targets for future relapse prevention interventions. Specifically, changes in the mechanisms underlying AUD will be investigated using the Competing Neurobehavioral Decision Systems (CNDS) framework, which posits that addiction and relapse arise from a regulatory imbalance between the impulsive and executive decision systems. To pursue this goal, participants with AUD will be recruited from the International Quit & Recovery Registry (IQRR), which was established in 2011 and currently has about 8,775 registrants. The IQRR provides a unique online resource that permits the scientific study of recovery processes and the highly efficient collection of data suitable for long-term repeated measurement research. We will use an accelerated longitudinal design, which allows the prospective characterization of psychosocial functioning, relapse, and CNDS functioning across 12 years of AUD recovery by recruiting participants with a range of different recovery lengths, up to 10 years. Over three years, participants will complete quarterly assessments, including measures of CNDS functioning. In Aim 1, we will examine the psychosocial functioning over long-term AUD recovery and how it is impacted by CNDS regulation. In Aim 2, we will examine relapse over long-term AUD recovery and how it is impacted by CNDS regulation. In Aim 3 we will examine the dynamic interaction of CNDS processes impacting the recovery using computational modeling. Together, the findings from this rigorous and innovative research project will improve our understanding of the temporal dynamics and underlying mechanisms of recovery from AUD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $701,911 )
2025	2025	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW	BLACKSBURG	VA	24060	MONTGOMERY	USA	Alcohol Research Programs	001	4	4/30/2025	NON-COMPETING CONTINUATION	$701,911
2025	2024	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW	BLACKSBURG	VA	24060	MONTGOMERY	USA	Alcohol Research Programs	000	3	2/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $701,911

Issue Date FY: 2024 ( Subtotal = $701,911 )
2024	2024	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW	BLACKSBURG	VA	24060	MONTGOMERY	USA	Alcohol Research Programs	000	3	2/7/2024	NON-COMPETING CONTINUATION	$631,719
2024	2024	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW	BLACKSBURG	VA	24060	MONTGOMERY	USA	Alcohol Research Programs	001	3	5/17/2024	NON-COMPETING CONTINUATION	$70,192
														Subtotal = $701,911

Issue Date FY: 2023 ( Subtotal = $709,584 )
2023	2023	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW	BLACKSBURG	VA	24060	MONTGOMERY	USA	Alcohol Research Programs	000	2	2/14/2023	NON-COMPETING CONTINUATION	$709,584
														Subtotal = $709,584

Issue Date FY: 2022 ( Subtotal = $725,202 )
2022	2022	VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY	300 TURNER ST NW STE 4200	BLACKSBURG	VA	24061	MONTGOMERY	USA	Alcohol Research Programs	000	1	2/21/2022	NEW	$725,202
														Subtotal = $725,202

Grand Total All Awards = $2,838,608

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Longitudinal Study of Recovery: Psychosocial Functioning, Relapse, and Neuro-Behavioral Markers

Award Number: R01AA029135

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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