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Traumatic stress increases alcohol drinking via endocannabinoid disinhibition of basolateral amygdala

Award Number: R01AA026531
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Humans with post-traumatic stress disorder (PTSD) are more likely to develop alcohol use disorder (AUD) than the general population, and AUD is the most commonly co-occurring mental health disorder in humans with PTSD. These conditions, separately and combined, affect millions of American, cause millions of deaths worldwide, and cost society billions of dollars. This proposal will examine individual differences in traumatic stress effects on specific brain circuits in male and female alcohol drinkers, and will manipulate those circuits to test their role in post-stress escalation of alcohol drinking. Here, we focus specifically on amygdala disinhibition and endocannabinoid signaling, but we will collect blood and brain samples that allow for subsequent analysis of predictive biomarkers, as well as follow-up experiments in alternate brain circuits. This project falls within the scope of the NIAAA mission to support biological and behavioral research underlying addictive behaviors. More importantly, the current proposal addresses the research objectives outlined in RFA-AA-17-016 by assessing alcohol drinking in a well characterized animal model of PTSD, determining the association of pre-stress alcohol drikning with the development of post-stress escalation of alcohol drinking, systematically testing the effect of sex on post-stress escalation of alcohol drinking, identifying neurobiological processes that underlie the transition to post-stress escalation of alcohol drinking, and identifying neurobiological targets for potential treatment of alcohol abuse in PTSD patients. Specifically, this application proposes the use of rat models to examine the neurobiology underlying stress-induced escalation of alcohol drinking in male and female animals. This application proposes the use of behavioral, electrophysiology, biochemistry, and molecular biology techniques to identify brain circuits altered by traumatic stress in subsets of alcohol drinkers, and to directly test the role of those circuits in escalated alcohol drinking after stress. The overall goals of the proposed work are to test the role of 1) amygdala disnihibition and 2) brain endocannabinoid signaling in traumatic stress-induced escalation of alcohol drinking in a stress-susceptible subpopulation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	5	10/24/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER-NEW ORLEANS	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	5	8/10/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $369,493 )
2021	2021	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	5	7/20/2021	NON-COMPETING CONTINUATION	$369,493
														Subtotal = $369,493

Issue Date FY: 2020 ( Subtotal = $369,409 )
2020	2020	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	4	7/22/2020	NON-COMPETING CONTINUATION	$369,409
														Subtotal = $369,409

Issue Date FY: 2019 ( Subtotal = $369,327 )
2019	2019	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	3	7/30/2019	NON-COMPETING CONTINUATION	$369,327
														Subtotal = $369,327

Issue Date FY: 2018 ( Subtotal = $369,247 )
2018	2018	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	2	8/2/2018	NON-COMPETING CONTINUATION	$369,247
2018	2017	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	1	7/30/2018	NEW	$0
														Subtotal = $369,247

Issue Date FY: 2017 ( Subtotal = $380,669 )
2017	2017	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	1	9/15/2017	NEW	$380,669
														Subtotal = $380,669

Grand Total All Awards = $1,858,145

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Traumatic stress increases alcohol drinking via endocannabinoid disinhibition of basolateral amygdala

Award Number: R01AA026531

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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