Saturday, September 7, 2024 9/7/2024

Oligo-Vascular Crosstalk in the Developing Brain: Implications for White Matter Injury in Congenital Heart Disease

Award Number: R00NS117804
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary This supplement application to the parent grant R00NS117804 is to support Ms. Iris Farnum, a postbaccalaureate research assistant in her first year of training. Iris will receive direct mentoring from me (Manideep Chavali, PI) and will be co-mentored by Dr. Ben Emery. This supplement will enhance Iris's training, enabling her to focus on her research and acquire the technical and professional skills necessary to become a competitive graduate school applicant and earn a Ph.D. in neuroscience. The research training plan has two main components. Firstly, Iris will develop technical expertise in skills such as single molecule fluorescent in situ hybridization (smFISH), immunohistochemical analysis of human and rodent neonatal brain injury specimens This will also encompass training in confocal microscopy, image acquisition, and data analysis. Secondly, she will gain expertise in developmental neuroscience concepts as she characterizes the functional consequences of hypoxic injury on oligodendroglial lineage cells and white matter maturation. For this purpose, she will also receive training in molecular biology techniques, including protein isolation and expression analysis, RNA isolation, and expression analysis. She will also become proficient in isolation and aseptic culture of primary oligodendroglial and ex vivo cerebellar slice cultures techniques. Additionally, Iris will receive training in data analysis, statistical methods, and effectively communicating research findings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $298,114 )
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	6/18/2024	SUPPLEMENT FOR EXPANSION	$57,906
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	6/12/2024	NON-COMPETING CONTINUATION	$240,208
														Subtotal = $298,114

Issue Date FY: 2023 ( Subtotal = $248,387 )
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	6/29/2023	NON-COMPETING CONTINUATION	$248,387
														Subtotal = $248,387

Issue Date FY: 2022 ( Subtotal = $248,737 )
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	9/22/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	9/21/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	9/20/2022	EXTENSION WITH OR WITHOUT FUNDS	$248,737
														Subtotal = $248,737

Grand Total All Awards = $795,238

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Oligo-Vascular Crosstalk in the Developing Brain: Implications for White Matter Injury in Congenital Heart Disease

Award Number: R00NS117804

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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