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Measuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan

Award Number: R00NS115918
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2021
PERIOD OF PERFORMANCE END DATE: 11/30/2024

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Measuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan - PROJECT SUMMARY/ABSTRACT Memory is core to human cognition, undergoes protracted developmental maturation and age-related decline, and is disrupted in numerous neurological and neuropsychiatric disorders. Despite the central role of memory in health and disease, remarkably little is known about the neural mechanisms supporting memory in humans. In this K99/R00 project, I propose to combine rare intracranial recordings from neurosurgical patients and advanced electrophysiological data analysis to track memory formation and maintenance in real time, and predict behavior in children, adolescents, and adults. With these spatiotemporally precise measures of memory formation and maintenance, this research will address critical gaps in knowledge about this core neurocognitive function. Comparative analysis between intracranial recordings and scalp electroencephalography (EEG) measures will further identify non-invasive EEG metrics applicable to developmental, lifespan, and disease-related research. Causal links between the medial temporal lobe, prefrontal cortex, and memory are well-established. However, there is a paucity of data on the mechanisms by which medial temporal and prefrontal regions interact to support memory in humans. The proposed research will determine the dynamic, multi-level neural circuit mechanisms that predict memory formation in humans across the lifespan. This research program will follow two complementary, largely unexplored directions. Aim 1 (K99 phase) will map predictors of memory formation and maintenance from the level of single neurons to that of large-scale neural circuits using simultaneous recordings obtained from medial temporal and prefrontal regions in adults. Aim 2 (R00 phase) will define electrophysiological predictors of memory success across the lifespan using intracranial recordings obtained from medial temporal and prefrontal regions in children, adolescents, and adults. The overarching hypothesis is that sub-second interactions in medial temporal, prefrontal, and medial temporal-prefrontal circuits will predict individual memory formation. Completion of these Aims will generate novel mechanistic explanations of human memory formation from childhood into adulthood. This research is directly relevant to Priorities #6 and #7 of the BRAIN 2025 Report and will prepare the Principal Investigator for a successful independent research career. To achieve these Aims, the proposed career development plan will build upon the Principal Investigator’s previous training with four goals to enhance her trajectory toward becoming an independent investigator: (1) analysis of single-unit neuronal data; (2) application of multivariate statistics to time-series data; (2) ethical aspects of conducting scientific research in clinical patients; and (4) research, mentoring, and administrative skills requisite to run a successful laboratory. Training will be accomplished through a balance of direct mentorship from animal and human neurophysiologists and coursework in neurophysiology, statistics, responsible conduct of research, and preparing for a future faculty position.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$82,401 )
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	21st Century Cures Act -Brain Research through Advancing Innovative Neurotechnologies	000	5	4/8/2025	NON-COMPETING CONTINUATION	-$82,401
														Subtotal = -$82,401

Issue Date FY: 2024 ( Subtotal = $261,364 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	12/14/2023	SUPPLEMENT FOR EXPANSION	$37,334
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies	000	5	12/1/2023	NON-COMPETING CONTINUATION	$224,030
														Subtotal = $261,364

Issue Date FY: 2023 ( Subtotal = $309,723 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	4	9/14/2023	SUPPLEMENT FOR EXPANSION	$23,466
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	1/31/2023	NON-COMPETING CONTINUATION	$24,893
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	12/23/2022	NON-COMPETING CONTINUATION	$224,030
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	1/13/2023	SUPPLEMENT FOR EXPANSION	$37,334
														Subtotal = $309,723

Issue Date FY: 2022 ( Subtotal = $354,790 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	8/15/2022	EXTENSION WITH OR WITHOUT FUNDS	$82,401
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	12/8/2021	EXTENSION WITH OR WITHOUT FUNDS	$248,923
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	8/5/2022	SUPPLEMENT FOR EXPANSION	$23,466
														Subtotal = $354,790

Grand Total All Awards = $843,476

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Measuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan

Award Number: R00NS115918

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2021

PERIOD OF PERFORMANCE END DATE: 11/30/2024

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