Tuesday, November 18, 2025 11/18/2025

The Mechanisms and Functional Consequences of Interhemispheric Plasticity

Award Number: R00NS112612
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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The Mechanisms and Functional Consequences of Interhemispheric Plasticity - Unilateral amputation, nerve damage or stroke cause widespread and robust changes in neural activity revealed in patient imaging studies. Successful rehabilitation of affected limbs after stroke, spared senses or intact limbs after nerve injury, or incorporation of prosthetics in an amputee’s daily life relies on the brain’s ability to adapt to these changes. On the other hand, chronic pain conditions such as phantom limb pain, hyperalgesia or complex regional pain syndrome are also proposed to be a result of cortical rewiring following some of these perturbations. The mechanisms underlying these phenotypes are unknown. We have developed an animal model which displays remarkably similar neural activity phenotypes during functional magnetic resonance imaging (fMRI). I have characterized the synaptic basis of the interhemispheric plasticity that is thought to underlie either adaptive or maladaptive plasticity in patients. The goal of the K99/R00 project is to characterize the specific neurons and synapses in the cortical circuit and determine if the changes we observe have a functional output to mediate more widespread changes in the brain. The functional relevance of these changes in connectivity will help determine if the plasticity we observe is adaptive, maladaptive or both. During the K99 training phase I will use a combination of fMRI, slice electrophysiology, viral tracing, and single nucleus RNA sequencing to identify key players that mediate these changes in neural activity. These results will guide experiments in the R00 phase, where I will modulate these cells with targeted interventions to re-calibrate the system. I will also use behavior to determine if the interventions are functionally relevant in vivo. The identification of specific subsets of neurons and their functional output will enable characterization of cortical rewiring after peripheral nerve injury. I will determine which neurons may be underlying adaptive or maladaptive plasticity. By targeting these neurons for therapeutic purposes, I will enhance adaptive plasticity to mediate better recovery or reduce pain conditions caused by maladaptive plasticity. These interventions may be clinically beneficial, but in order to be most effective complete characterization of the circuit underlying these changes is required.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $241,530 )
2024	2024	THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.	6720A ROCKLEDGE DR	BETHESDA	MD	20817	MONTGOMERY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	6/25/2024	NON-COMPETING CONTINUATION	$241,530
														Subtotal = $241,530

Issue Date FY: 2023 ( Subtotal = $249,000 )
2023	2023	THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.	6720A ROCKLEDGE DR	BETHESDA	MD	20817	MONTGOMERY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	5/18/2023	NON-COMPETING CONTINUATION	$249,000
														Subtotal = $249,000

Issue Date FY: 2022 ( Subtotal = $249,000 )
2022	2022	HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC., THE	6720-A ROCKLEDGE DR STE 100	BETHESDA	MD	20817	MONTGOMERY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/12/2022	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $739,530

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The Mechanisms and Functional Consequences of Interhemispheric Plasticity

Award Number: R00NS112612

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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