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Is Preeclampsia and Spontaneous Preterm Delivery Associated with Vascular and Cardiac Function?

Award Number: R00NR018679
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Is Preeclampsia and Spontaneous Preterm Delivery Associated with Vascular and Cardiac Function? - ABSTRACT The broad, long term objective of this award is to facilitate independence as a nurse scientist, generate preliminary evidence and facilitate an R01 application. The overarching goal of this study is to compare vascular function, cardiac structure and function and lipid biomarker/fibrosis proteomics between each adverse pregnancy group to gain insight into mechanisms leading to adverse outcomes and provide opportunities for intervention. The proposed study, “Is Preeclampsia and Spontaneous Preterm Delivery Associated with Vascular and Cardiac Dysfunction?” is a longitudinal, comparative design study, were I will compare 4 groups; 1) women who experience term preeclampsia (≥37 weeks); 2) spontaneous preterm delivery (sPTD) (≤ 34 weeks) and; 3) preterm preeclampsia (PreE) (<37 weeks) compared to women who experience 4) full-term deliveries (≥39 weeks) at 3-time points (24-72 hours, 1 and 2 years postpartum). My long-term goals are to: (1) employ comprehensive mechanistic phenotyping and utilizing cardiac magnetic resonance imaging (CMRI) techniques to refine the current understanding of mechanisms linking adverse pregnancy outcomes (APOs) and atherosclerotic cardiovascular disease (ASCVD) risk; (2) translate scientific advances across cardiovascular, nursing science, proteomics and women’s health research in order to elucidate how we further phenotype APOs (3) enhance our ability to identify individuals at risk for future ASCVD early in the course of ASCVD, before the onset of clinical disease; (4) ultimately change ASCVD disease course for women who are at increased risk (5) lead a multidisciplinary team of translational investigators focused on the research. The following key variables related to future risk of cardiovascular disease will be evaluated: vascular function (augmentation index and pulse wave velocity) and cardiac structure and function measured by cardiac magnetic resonance imaging utilizing Cine, Tissue Tagging (left ventricular systolic and diastolic function including strain), T1 mapping (fibrosis), at 1 and 2 years postpartum.) Secondary measures include novel cardiac biomarkers including a lipid biomarker collection for 72 proteins and lipids, proteomics fibrosis panel [(Matric metalloproteinases (MMPs) and Transforming Growth Factor-β1 (TGF- β1). Ultimately, the outcome of this research will inform relationships between TPre, sPTD and PreE which is an important step to uncover the link between APOs and future maternal ASCVD risk. This effort will shape the development of specific treatment targets for new opportunities in chronic ASCVD prevention. Achieved training goals will augment and facilitate independence, generate preliminary evidence and facilitate an R01 application.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Nursing Research	000	5	6/27/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $249,000 )
2024	2024	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Nursing Research	000	5	5/21/2024	NON-COMPETING CONTINUATION	$249,000
														Subtotal = $249,000

Issue Date FY: 2023 ( Subtotal = $286,941 )
2023	2023	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Nursing Research	001	4	5/19/2023	NON-COMPETING CONTINUATION	$249,000
2023	2022	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Nursing Research	000	3	1/13/2023	EXTENSION WITH OR WITHOUT FUNDS	$37,941
														Subtotal = $286,941

Issue Date FY: 2022 ( Subtotal = $249,000 )
2022	2022	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Nursing Research	000	3	5/31/2022	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $784,941

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Is Preeclampsia and Spontaneous Preterm Delivery Associated with Vascular and Cardiac Function?

Award Number: R00NR018679

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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