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Quantitative Characterization of the Extra Cellular Matrix Components of Connective Tissue: Fingerprinting Macromolecular Components through Low-Field Magnetic Resonance

Award Number: R00GM140338
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Fibrotic activity, the accumulation of macromolecules, alters the composition and microstructural organization musculoskeletal connective tissue. The ability to non-invasively quantify and characterize the significant extracellular matrix components such as proteoglycan content and collagen fibrils organization is important clinically since fibrosis is a common inflammatory response that plays a role in many pathologies. Recent advances in instrumentation for low field magnetic resonance (MR) has enabled its adoption in the field of macromolecular characterization, porous media, and recently biological tissues. LF MR is advantageous as an affordable non-cryogen alternative to high-field MR imaging with a greater detectable dynamic range of quantitative MR parameters. This adaptation for this imaging modality is limited by the lack of appropriate phantoms of connective tissue and the identification of biomarkers for healthy and diseased tissue. Composite gels that replicate the salient structural and compositional features of connective tissue will be developed and used to optimize low field MR methods and identify LF biomarkers. These methods will be applied to articular cartilage and lumbodorsal fascia connective tissues. The project is anticipated to have a significant positive impact on the clinical capability and utility of LF MR as an affordable point of care diagnostic application.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $248,972 )
2024	2024	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Biomedical Research and Research Training	000	2	6/6/2024	EXTENSION WITH OR WITHOUT FUNDS	$248,972
														Subtotal = $248,972

Grand Total All Awards = $248,972

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Quantitative Characterization of the Extra Cellular Matrix Components of Connective Tissue: Fingerprinting Macromolecular Components through Low-Field Magnetic Resonance

Award Number: R00GM140338

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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