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Diversity Supplement for Updating the Mixture in Mechanisms of Phthalate Toxicity in the Ovary

Award Number: R00ES031150
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT This is a proposal for a Diversity Supplement to fund hands-on research training and career development for a promising research technician receiving post-baccalaureate training at the New Jersey Institute of Technology. The parent grant for this proposal is R00ES031150 to facilitate Dr. Genoa Warner’s transition to an independent research career as an Assistant Professor in the Department of Chemistry and Environmental Science at the New Jersey Institute of Technology, where she draws from her diverse scientific background in chemistry and biology to investigate important research questions in environmental health. Dr. Warner has extensive training in endocrine disruption and sustainable chemistry and has completed postdoctoral training in reproductive toxicology at the University of Illinois under the mentorship of Dr. Jodi A. Flaws, where she has learned technical and profession skills necessary for her to become a successful independent investigator and leader in the field of reproductive toxicology. In her new laboratory, Dr. Warner investigates the mechanisms by which phthalates, a group of endocrine disrupting chemicals with ubiquitous human exposure, cause ovarian toxicity. Further, she investigates the metabolism of phthalates by ovarian tissue because phthalate metabolites mediate phthalate- inducted toxic effects, contributing to infertility and premature ovarian failure. In the prosed studies, Dr. Warner will mentor the Diversity Supplement candidate, Stephanie Martinez, in pursuing research within the scope of the original project aims to craft her own research niche. Specific Aim 1 of the parent project aims to identify how phthalates partition into ovarian tissue during culture via mass spectrometry and imaging methods using chemically modified phthalates. Specific Aim 2 will determine how phthalate toxicity varies between cell types of the ovary using next generation sequencing techniques. Finally, Specific Aim 3 will identify the genomic localization of phthalates in the ovary by adapting the biochemical technique of chemical affinity capture paired with massively parallel DNA sequencing (Chem-seq) to provide information on the genes and proteins targeted by phthalates. Overall, the proposed studies will provide novel chemical and mechanistic insight into causes of phthalate-induced toxicity in the ovary that contribute to female infertility and premature ovarian failure. The methods combine chemical and biological techniques to develop a new, widely applicable technology for investigating the mechanisms of endocrine disrupting chemicals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $465,118 )
2023	2023	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Environmental Health	002	4	6/19/2023	SUPPLEMENT FOR EXPANSION	$69,013
2023	2023	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Environmental Health	003	4	6/22/2023	SUPPLEMENT FOR EXPANSION	$74,194
2023	2023	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Environmental Health	001	4	6/15/2023	NON-COMPETING CONTINUATION	$245,939
2023	2022	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Environmental Health	000	3	11/14/2022	EXTENSION WITH OR WITHOUT FUNDS	$75,972
														Subtotal = $465,118

Issue Date FY: 2022 ( Subtotal = $304,725 )
2022	2022	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Environmental Health	000	3	5/5/2022	EXTENSION WITH OR WITHOUT FUNDS	$249,000
2022	2022	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Environmental Health	001	3	8/17/2022	SUPPLEMENT FOR EXPANSION	$55,725
														Subtotal = $304,725

Grand Total All Awards = $769,843

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Diversity Supplement for Updating the Mixture in Mechanisms of Phthalate Toxicity in the Ovary

Award Number: R00ES031150

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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