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Tissue structure and mechanical function relationships of the human temporomandibular lateral capsule-ligament: Investigation of sexual and racial dimorphisms

Award Number: R00DE031345
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/04/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Tissue structure and mechanical function relationships of the human temporomandibular lateral capsule-ligament: Investigation of sexual and racial dimorphisms - Project Summary/Abstract As many as 10 million adults in the United States have temporomandibular disorders (TMDs). Females experience TMDs at higher rates compared to males and African Americans have higher TMD incidence, yet lower prevalence compared to white Americans. Despite these findings, etiological mechanisms contributing to prevalence and incidence disparities by sex and race are largely unknown. Given our recent reports on sexual dimorphisms in incremental tensile stiffness and fixed charge density of the human temporomandibular disc, it is hypothesized that additional sexual dimorphisms may exist in properties of the temporomandibular joint (TMJ). Similar differences are also hypothesized to exist between racial groups, although this possibility has not yet been explored, which may limit research translational confidence across racial groups. The lateral capsule- ligament (LCL) complex, which spans the temporal bone and mandibular condyle, could impact temporomandibular disc derangement (TMDD) risk through a ‘loose ligament’ mechanism affecting joint articulation postulated in prior literature. Furthermore, sex- and race-specific differences in potential risk and resiliency factors may contribute to differential risk of TMDD development and observed TMD prevalence and incidence disparities. Our long-term goal is to enable individualized TMDD risk assessment to increase applicability of generated risk estimates. The objective of this study is to describe sex- and race-specific mechano-chemical LCL complex properties to investigate potential contributions to TMD disparities between sexes and racial groups. The central hypothesis is that TMJ properties observed in females and African Americans will be associated with higher risk of TMDD development compared to those of males and white Americans. The proposed studies will enable the determination of sex- and race-specific differences in potential mechanical and chemical risk factors for TMD development (Aims 1 and 2). This determination will contribute to a better understanding of TMJ properties across diverse populations and is crucial to enabling understanding of TMD incidence and prevalence disparities. Finite element models will also be used to investigate how differences between sexes and racial groups impact the temporomandibular loading environment, which will be developed, refined, and interpreted during the independent phase (Aim 3). This proposal aims to further development of scientific expertise and skill acquisition in temporomandibular and craniofacial biomechanics, with a plan to transition from mentored post-doctoral fellowship to independent faculty. NIH T32 training and professional development resources, joint resources and network of the Clemson- MUSC Bioengineering program, and the Clemson University Pathways Mentoring Program provide an ideal inter-disciplinary training environment to prepare for and transition to independence following the postdoctoral fellowship period.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $249,000 )
2026	2026	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Oral Diseases and Disorders Research	001	6	8/19/2026	NON-COMPETING CONTINUATION	$249,000
2026	2025	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Oral Diseases and Disorders Research	000	5	3/10/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $249,000

Issue Date FY: 2025 ( Subtotal = $249,002 )
2025	2025	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Oral Diseases and Disorders Research	003	5	8/11/2025	NON-COMPETING CONTINUATION	$249,000
2025	2024	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Oral Diseases and Disorders Research	002	3	5/13/2025	EXTENSION WITH OR WITHOUT FUNDS	$0
2025	2024	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Oral Diseases and Disorders Research	001	4	4/30/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$249,000
2025	2024	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Oral Diseases and Disorders Research	000	3	4/30/2025	EXTENSION WITH OR WITHOUT FUNDS	-$248,998
														Subtotal = $249,002

Issue Date FY: 2024 ( Subtotal = $249,000 )
2024	2024	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Oral Diseases and Disorders Research	000	3	9/25/2024	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $747,002

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Tissue structure and mechanical function relationships of the human temporomandibular lateral capsule-ligament: Investigation of sexual and racial dimorphisms

Award Number: R00DE031345

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/04/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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