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The development of a technology-based information support intervention (iSupport) among patients with differentiated thyroid cancer post radioactive iodine therapy

Award Number: R00CA277588
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/02/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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The development of a technology-based information support intervention (iSupport) among patients with differentiated thyroid cancer post radioactive iodine therapy - Radioactive iodine (RAI) therapy is routinely used among patients diagnosed with differentiated thyroid cancer (DTC), with approximately 76% of patients receiving RAI. Patients with DTC post RAI treatment report extensive short-term and late effects of treatment, symptom burden, and unmet informational needs about treatment-related side effects. However, thyroid cancer is frequently referred to as the “good cancer” and is an understudied cancer population for survivorship research and web-based interventions. One way to address these gaps is through digital technologies such as a web-based intervention, which can empower patients with direct access to educational and support tools to improve health-related quality of life (HRQOL) and reduce symptom burden. I propose to develop and evaluate a web-based intervention, called RAI Support (Radioactive Iodine Support), to improve HRQOL and reduce symptom burden among patients diagnosed with DTC post RAI. I propose the following aims: Aim 1 (R00). Assess the feasibility and acceptability of the RAI Support intervention, Aim 2 (R00). Test the preliminary efficacy of the RAI Support intervention vs. TAU among patients with DTC on HRQOL, and Aim 3 (R00). Conduct exploratory analyses on changes in RAI symptom burden, symptom interference, RAI knowledge, self-efficacy for managing symptoms, and cancer-related distress between RAI Support vs. TAU. The R00 phase will involve conducting a pilot randomized controlled trial (RCT; N=88) to: 1) assess the feasibility and acceptability of RAI Support, 2) test the preliminary efficacy of RAI Support compared to a (TAU) control group with DTC patients on HRQOL, and 3) conduct exploratory analyses on changes in RAI symptom burden, symptom interference, RAI knowledge, self-efficacy for managing symptoms, and cancer-related distress between RAI Support vs. TAU.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $248,999 )
2026	2026	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Research Manpower	000	4	3/2/2026	NON-COMPETING CONTINUATION	$248,999
														Subtotal = $248,999

Issue Date FY: 2025 ( Subtotal = $248,999 )
2025	2025	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Research Manpower	001	3	5/27/2025	EXTENSION WITH OR WITHOUT FUNDS	$24,897
2025	2025	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Research Manpower	000	3	4/2/2025	EXTENSION WITH OR WITHOUT FUNDS	$224,102
														Subtotal = $248,999

Grand Total All Awards = $497,998

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The development of a technology-based information support intervention (iSupport) among patients with differentiated thyroid cancer post radioactive iodine therapy

Award Number: R00CA277588

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/02/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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