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Interpersonal Emotion Regulation in Neurodegenerative Disease: Pathways to Caregiver Health

Award Number: R00AG073617
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Interpersonal Emotion Regulation in Neurodegenerative Disease: Pathways to Caregiver Health - PROJECT SUMMARY Neurodegenerative diseases lead to profound cognitive, emotional, and functional impairments that leave individuals dependent upon close relational partners who provide care. Although caregiving is a positive experience for many individuals, providing care for an individual who has socioemotional deficits due to neurodegenerative disease can lead to adverse consequences for spousal caregivers, including poor mental and physical health outcomes. However, little research examines the dyadic, interpersonal pathways through which care recipients’ socioemotional deficits lead to health problems for their caregivers. The current research focuses on interpersonal emotion regulation – the extent to which a caregiver’s negative emotion is downregulated and a caregiver’s positive emotion is upregulated during conflict and an acute stressor with their care recipient – as a potential pathway linking care recipients’ socioemotional deficits to their caregivers’ health problems. The research will compare neurotypicals with individuals who have Alzheimer’s Disease (AD) and behavioral variant frontotemporal dementia (bvFTD) to understand how these different disease types influence interpersonal emotion regulation (Aim 1). The research will delineate the neural, autonomic, and behavioral correlates of interpersonal emotion regulation (Aim 2), with an emphasis on disease related atrophy, autonomic, and behavioral factors theorized to subserve interpersonal emotion regulation, including vagal flexibility, visual attention to other’s emotional expressions, and empathy. Finally, this research will examine whether poor interpersonal emotion regulation impacts caregiver health longitudinally (Aim 3). The proposed research will provide a more nuanced framework for understanding how socioemotional impairments due to neurodegenerative diseases affect caregivers’ health over time, and advance our understanding of interpersonal emotion regulation and the dyadic processes that promote or hinder healthy aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $109,200 )
2025	2025	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Aging Research	000	4	6/17/2025	SUPPLEMENT FOR EXPANSION	$109,200
														Subtotal = $109,200

Issue Date FY: 2024 ( Subtotal = $407,856 )
2024	2024	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Aging Research	002	4	6/25/2024	SUPPLEMENT FOR EXPANSION	$87,507
2024	2024	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Aging Research	001	4	6/24/2024	SUPPLEMENT FOR EXPANSION	$74,218
2024	2024	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Aging Research	000	4	6/21/2024	NON-COMPETING CONTINUATION	$246,131
														Subtotal = $407,856

Issue Date FY: 2023 ( Subtotal = $392,718 )
2023	2023	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Aging Research	002	3	6/16/2023	SUPPLEMENT FOR EXPANSION	$68,033
2023	2023	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Aging Research	004	3	7/27/2023	SUPPLEMENT FOR EXPANSION	$58,110
2023	2023	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Aging Research	005	3	8/11/2023	SUPPLEMENT FOR EXPANSION	$17,023
2023	2023	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Aging Research	001	3	6/1/2023	NON-COMPETING CONTINUATION	$246,105
2023	2022	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Aging Research	003	2	7/24/2023	EXTENSION WITH OR WITHOUT FUNDS	$3,447
2023	2022	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Aging Research	000	2	5/2/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $392,718

Issue Date FY: 2022 ( Subtotal = $249,000 )
2022	2022	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Aging Research	000	2	8/30/2022	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $1,158,774

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Interpersonal Emotion Regulation in Neurodegenerative Disease: Pathways to Caregiver Health

Award Number: R00AG073617

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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