Wednesday, October 15, 2025 10/15/2025

LSUHSC-NO Comprehensive Alcohol-HIV/AIDS Research Center (CARC)

Award Number: P60AA009803
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/1996
PERIOD OF PERFORMANCE END DATE: 08/31/2030

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LSUHSC-NO Comprehensive Alcohol-HIV/AIDS Research Center (CARC) - The Louisiana State University Health Sciences Center-New Orleans (LSUHSC-NO) Comprehensive Alcohol-HIV/AIDS Research Center (CARC) is a multi-institutional, multidisciplinary team of scientists with a research focus on the impact of alcohol use disorder (AUD) on human immunodeficiency virus (HIV) disease and age-related comorbidities. The translational studies are conducted in a longitudinal cohort of in-care, virally-suppressed persons with HIV (PWH; N≈400) together with an age- and sex-matched HIV-seronegative cohort, and focus on integration of environmental (neighborhood) and behavioral (diet, alcohol, and other substance use) factors that increase risk of comorbidities. Moreover, studies proposed will examine the impact of behavioral and pharmacological interventions respectively aimed at reducing alcohol use and related co-morbidities, and improving bioenergetics at the immune, metabolic, and nervous system levels. Our translational approach builds on relevant findings from studies in the simian immunodeficiency virus (SIV)-infected nonhuman primate (NHP) that reveal the deleterious consequences of chronic alcohol despite viremic control: specifically, gut dysbiosis and leak promoting chronic immune activation, and senescence. An Administrative Core provides administrative and fiscal oversight, supports data management and statistical analysis, and promotes novel and innovative research investigations through the development of new pilot projects. Four Research Components (RCs) test hypotheses in our human longitudinal cohort complemented by mechanistic (whole body, organ, and cellular) longitudinal studies in CBA treated SIV+/- NHPs fed a high fat-high sucrose (a.k.a. Western) diet randomized to metformin+/-. Proposed studies introduce a behavioral and pharmacological intervention to evolve, expand, and refine our mechanistic bidirectional (NHP‒PWH‒NHP) approach. RC1 focuses on the impact of environmental and interpersonal stress, anxiety, depression, and AUD on risk for comorbidities. RC2 examines the mechanisms underlying alcohol-associated risk for age-related comorbidities. RC3 focuses on the impact of AUD on biobehavioral mechanisms associated with neurological comorbidities, specifically pain and cognitive deficits. RC4 expands on the mechanisms underlying alcohol-mediated alterations in immunosenescent T cells. The Experimental and Analytical Core provides oversight for the preclinical and clinical longitudinal studies, biospecimen collection, processing, and analysis. An Information Dissemination Core promotes training and accelerates the translation and dissemination of CARC research findings to current and future health care providers and individuals at high risk for HIV and AUD. The CARC will continue to leverage and synergize with existing institutional resources. Our access to a unique population of PWH in a southeast urban region, established expertise in biomedical and behavioral research, state-of-the-art research facilities, outstanding scientific environment, and strong institutional support will ensure that the proposed projects will continue to advance our collective understanding of the consequences of alcohol use in PWH.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,400,917 )
2025	2025	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	002	32	9/10/2025	COMPETING CONTINUATION	$1,455,419
2025	2024	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	31	4/3/2025	NON-COMPETING CONTINUATION	-$54,502
2025	2024	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	31	11/7/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,400,917

Issue Date FY: 2024 ( Subtotal = $1,406,400 )
2024	2024	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER-NEW ORLEANS	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	31	11/27/2023	NON-COMPETING CONTINUATION	$1,406,400
2024	2024	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	31	9/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,406,400

Issue Date FY: 2023 ( Subtotal = $1,695,629 )
2023	2023	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER-NEW ORLEANS	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	30	2/23/2023	NON-COMPETING CONTINUATION	$144,568
2023	2023	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER-NEW ORLEANS	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	002	30	4/5/2023	SUPPLEMENT FOR EXPANSION	$249,949
2023	2023	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER-NEW ORLEANS	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	30	11/29/2022	NON-COMPETING CONTINUATION	$1,301,112
														Subtotal = $1,695,629

Issue Date FY: 2022 ( Subtotal = $1,480,517 )
2022	2022	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	29	12/3/2021	NON-COMPETING CONTINUATION	$1,332,466
2022	2022	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER-NEW ORLEANS	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	29	6/22/2022	NON-COMPETING CONTINUATION	$148,051
														Subtotal = $1,480,517

Issue Date FY: 2021 ( Subtotal = $2,014,986 )
2021	2021	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	002	28	3/29/2021	SUPPLEMENT FOR EXPANSION	$367,500
2021	2021	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	006	28	9/6/2021	SUPPLEMENT FOR EXPANSION	$109,700
2021	2021	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	28	12/1/2020	NON-COMPETING CONTINUATION	$1,482,737
2021	2021	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	003	28	4/13/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	005	28	6/24/2021	NON-COMPETING CONTINUATION	-$109,700
2021	2021	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	28	1/14/2021	NON-COMPETING CONTINUATION	$164,749
2021	2020	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	004	27	5/13/2021	COMPETING CONTINUATION	$0
														Subtotal = $2,014,986

Issue Date FY: 2020 ( Subtotal = $1,634,417 )
2020	2020	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	003	27	6/2/2020	SUPPLEMENT FOR EXPANSION	$14,700
2020	2020	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	004	27	9/10/2020	SUPPLEMENT FOR EXPANSION	$102,458
2020	2020	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	002	27	3/30/2020	COMPETING CONTINUATION	$389,598
2020	2020	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	27	12/20/2019	COMPETING CONTINUATION	$1,517,259
2020	2019	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	26	3/30/2020	NON-COMPETING CONTINUATION	-$389,598
														Subtotal = $1,634,417

Issue Date FY: 2019 ( Subtotal = $1,796,736 )
2019	2019	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	26	11/26/2018	NON-COMPETING CONTINUATION	$1,796,736
2019	2019	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	002	26	1/31/2019	NON-COMPETING CONTINUATION	$0
2019	2019	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	26	1/28/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,796,736

Issue Date FY: 2018 ( Subtotal = $1,796,698 )
2018	2018	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	25	5/25/2018	NON-COMPETING CONTINUATION	$179,670
2018	2018	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	25	11/14/2017	NON-COMPETING CONTINUATION	$1,617,028
														Subtotal = $1,796,698

Issue Date FY: 2017 ( Subtotal = $1,797,109 )
2017	2017	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	24	8/22/2017	NON-COMPETING CONTINUATION	$179,712
2017	2017	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	24	11/15/2016	NON-COMPETING CONTINUATION	$1,617,397
														Subtotal = $1,797,109

Issue Date FY: 2016 ( Subtotal = $1,894,970 )
2016	2016	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	23	2/2/2016	NON-COMPETING CONTINUATION	$179,707
2016	2016	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	002	23	9/14/2016	SUPPLEMENT FOR EXPANSION	$97,910
2016	2016	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	23	11/17/2015	NON-COMPETING CONTINUATION	$1,617,353
														Subtotal = $1,894,970

Issue Date FY: 2015 ( Subtotal = $1,800,000 )
2015	2015	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	002	22	1/27/2015	COMPETING CONTINUATION	$300,000
2015	2015	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	22	12/8/2014	COMPETING CONTINUATION	$1,500,000
2015	2015	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	003	22	2/11/2015	COMPETING CONTINUATION	$0
2015	2014	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	21	12/3/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,800,000

Issue Date FY: 2014 ( Subtotal = $1,704,987 )
2014	2014	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	001	21	3/10/2014	NON-COMPETING CONTINUATION	$123,041
2014	2014	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Alcohol Research Programs	000	21	11/25/2013	NON-COMPETING CONTINUATION	$1,581,946
														Subtotal = $1,704,987

Grand Total All Awards = $39,683,296

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LSUHSC-NO Comprehensive Alcohol-HIV/AIDS Research Center (CARC)

Award Number: P60AA009803

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/1996

PERIOD OF PERFORMANCE END DATE: 08/31/2030

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