Tuesday, July 1, 2025 7/1/2025

CNS Effects of Alcohol: Cellular Neurobiology

Award Number: P60AA006420
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/1983
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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CNS Effects of Alcohol: Cellular Neurobiology - Abstract Overall The Scripps Research Institute-Alcohol Research Center (TSRI-ARC) will focus on the cellular and molecular mechanisms that modulate top-down medial prefrontal control of the central amygdala and underlie stress- induced vulnerability to relapse and excessive drinking during protracted abstinence. Our approach consists of coordinated interdisciplinary molecular, neuroproteomic, cellular, neurocircuitry, connectomic, neuropharmacological, and behavioral methods. Specific hypotheses are: (1) Protracted abstinence involves increased vulnerability to stress-induced relapse via changes in modulatory control circuitry from the infralimbic cortex to the central nucleus of the amygdala. (2) Modulatory control changes are a function of altered glutamatergic and γ-aminobutyric acid synaptic transmission, due to actions of stress-related molecules (including hypocretin, corticotropin-releasing factor, dynorphin, and nociceptin) and astrocytic dysfunction. (3) These neurocircuitry changes are associated with altered connectivity and decreased modularity of brain networks, leading to increased vulnerability to stress-induced relapse. (4) Novel translationally relevant ligands of neurobiological targets identified by TSRI-ARC will attenuate the reinstatement of stress-induced alcohol seeking, excessive drinking, and stress-related behaviors in animal models. Our Center-wide aims will be met by 5 Research Components (Functional Connectomics, Neuropharmacology, Molecular, Neurophysiology, and Neurocircuitry), and 4 Cores (Administrative, Dissemination, Animal Models, and Neuroproteomics). The Administrative Core is organized to optimize Center-wide functioning, utilization of Core resources, and research collaborations in the Center-at-Large. TSRI-ARC is structured to promote Diversity, Equity, and Inclusion (DEI), training and career development at all levels of the Center. TSRI-ARC rapidly disseminates its discoveries to scientific, healthcare and lay stakeholders, and engages young people from health disparity backgrounds for internships in TSRI-ARC laboratories to learn about alcohol and careers in alcohol research. Center-wide Specific Aims are: (1) To characterize the cellular and molecular mechanisms that modulate top-down medial prefrontal control of the central amygdala and underlie stress-induced vulnerability to relapse and excessive drinking during protracted abstinence. (2) To understand how reversal of the cellular and molecular stress mechanisms that impair modulatory control systems can prevent stress-induced relapse and excessive drinking during protracted abstinence. (3) To evaluate the efficacy of neuropharmacological targets identified by TSRI- ARC for reversing dysregulated connectivity within and between brain stress systems and modulatory control circuits in protracted abstinence. The ultimate goal of TSRI-ARC is to positively influence public health by generating data relevant to the identification of neurobiological mechanisms mediating alcohol use disorder (AUD), and guide the translation of our basic research findings toward clinical applications to help in prevention, diagnosis, and treatment of individuals with AUD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,857,335 )
2025	2025	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	42	5/13/2025	NON-COMPETING CONTINUATION	$1,857,335
														Subtotal = $1,857,335

Issue Date FY: 2024 ( Subtotal = $1,830,941 )
2024	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	002	41	12/14/2023	NON-COMPETING CONTINUATION	$1,830,941
2024	2023	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	40	11/8/2023	COMPETING CONTINUATION	$1
2024	2022	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	39	11/8/2023	NON-COMPETING CONTINUATION	-$1
														Subtotal = $1,830,941

Issue Date FY: 2023 ( Subtotal = $1,934,156 )
2023	2023	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	40	12/26/2022	COMPETING CONTINUATION	$1,834,175
2023	2023	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	40	7/24/2023	SUPPLEMENT FOR EXPANSION	$99,981
														Subtotal = $1,934,156

Issue Date FY: 2022 ( Subtotal = $1,809,355 )
2022	2022	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	39	12/22/2021	NON-COMPETING CONTINUATION	$1,628,418
2022	2022	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	39	7/13/2022	NON-COMPETING CONTINUATION	$180,937
														Subtotal = $1,809,355

Issue Date FY: 2021 ( Subtotal = $2,057,855 )
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	38	12/24/2020	NON-COMPETING CONTINUATION	$1,628,418
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	002	38	7/7/2021	SUPPLEMENT FOR EXPANSION	$248,500
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	38	2/23/2021	NON-COMPETING CONTINUATION	$180,937
														Subtotal = $2,057,855

Issue Date FY: 2020 ( Subtotal = $1,809,355 )
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	37	12/20/2019	NON-COMPETING CONTINUATION	$1,809,355
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	37	9/2/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,809,355

Issue Date FY: 2019 ( Subtotal = $1,809,355 )
2019	2019	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	36	12/11/2018	NON-COMPETING CONTINUATION	$1,809,355
2019	2019	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	36	7/3/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,809,355

Issue Date FY: 2018 ( Subtotal = $1,809,355 )
2018	2018	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	35	12/25/2017	COMPETING CONTINUATION	$1,809,355
2018	2017	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	34	4/3/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,809,355

Issue Date FY: 2017 ( Subtotal = $1,798,217 )
2017	2017	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	34	12/21/2016	NON-COMPETING CONTINUATION	$1,618,396
2017	2017	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	002	34	7/19/2017	NON-COMPETING CONTINUATION	$154,200
2017	2017	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	34	1/5/2017	NON-COMPETING CONTINUATION	$25,621
														Subtotal = $1,798,217

Issue Date FY: 2016 ( Subtotal = $1,798,217 )
2016	2016	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	33	3/3/2016	EXTENSION WITH OR WITHOUT FUNDS	$1,798,217
														Subtotal = $1,798,217

Issue Date FY: 2015 ( Subtotal = $1,744,269 )
2015	2015	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	32	12/30/2014	NON-COMPETING CONTINUATION	$1,618,396
2015	2015	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	32	1/28/2015	NON-COMPETING CONTINUATION	$125,873
														Subtotal = $1,744,269

Issue Date FY: 2014 ( Subtotal = $1,733,243 )
2014	2014	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	31	12/30/2013	NON-COMPETING CONTINUATION	$1,608,165
2014	2014	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	31	4/8/2014	NON-COMPETING CONTINUATION	$125,078
														Subtotal = $1,733,243

Issue Date FY: 2013 ( Subtotal = $1,805,789 )
2013	2013	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	30	2/8/2013	COMPETING CONTINUATION	$1,786,839
2013	2013	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	30	3/1/2013	SUPPLEMENT FOR EXPANSION	$18,950
														Subtotal = $1,805,789

Issue Date FY: 2012 ( Subtotal = $1,686,668 )
2012	2012	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	29	12/30/2011	NON-COMPETING CONTINUATION	$1,549,194
2012	2012	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	29	2/14/2012	NON-COMPETING CONTINUATION	$137,474
														Subtotal = $1,686,668

Issue Date FY: 2011 ( Subtotal = $1,737,548 )
2011	2011	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	28	12/29/2010	NON-COMPETING CONTINUATION	$1,626,977
2011	2011	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	001	28	7/6/2011	NON-COMPETING CONTINUATION	$110,571
														Subtotal = $1,737,548

Issue Date FY: 2010 ( Subtotal = $1,807,505 )
2010	2010	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	27	1/21/2010	NON-COMPETING CONTINUATION	$1,807,505
														Subtotal = $1,807,505

Issue Date FY: 2009 ( Subtotal = $1,824,721 ) (Continued on the next page)
2009	2009	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Alcohol Research Programs	000	26	12/30/2008	NON-COMPETING CONTINUATION	$1,642,250
Grand Total All Awards = $42,603,523

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CNS Effects of Alcohol: Cellular Neurobiology

Award Number: P60AA006420

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/1983

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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