Sunday, February 15, 2026 2/15/2026

Penn Innovation in Suicide Prevention Implementation Research (INSPIRE) Center

Award Number: P50MH127511
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Penn Innovation in Suicide Prevention Implementation Research (INSPIRE) Center - This proposal is to develop the University of Pennsylvania’s Innovation in Suicide Prevention Implementation Research (INSPIRE) Center. Suicide is a leading cause of death in the US. Guided by a conceptual model based on the Integrated Behavior Model, which posits that organizational culture, policies, and resources (or lack thereof) impact the provider’s attributes and behaviors, INSPIRE brings together psychology, implementation science, health economics, machine learning, health information technology, psychiatry and participatory research experts to apply innovative interdisciplinary approaches to suicide prevention. INSPIRE’s overarching goals are to develop and adapt practice-based and other suicide prevention interventions and to design and test implementation strategies to optimize how evidence-based practices can be brought to scale efficiently and with high fidelity, for optimal effectiveness. INSPIRE will prioritize strategies that can be rapidly deployed in a range of practice settings, including those with limited resources, thereby increasing their reach and public health impact. Penn INSPIRE will use state-of-the-science methods from participatory research to actively engage stakeholders from many sectors – including patients, providers, and payers – at every level of its work to accomplish its Specific Aims. INSPIRE will apply innovative, interdisciplinary behavior change and implementation science methods to develop, adapt, and evaluate cost effective interventions. A Signature Project will use a stepped wedge study design to test an innovative organizational strategy that leverages telehealth to deliver high quality Safety Planning Intervention and follow-up services in Emergency Departments. Three Exploratory Projects will test novel strategies for suicide prevention across individual, clinician, and organizational levels that will lay the foundation for more definitive studies. INSPIRE will also support 10 pilot projects and an innovative Methods Core that will develop and test new methods to advance research at the intersection of suicide prevention and implementation science. The Suicide Prevention Scholars Program will expand the cadre of suicide prevention researchers by engaging both emerging investigators and established scientists who do not currently work on suicide prevention through content, design. and methodological mentoring and capacity-building. By catalyzing interdisciplinary, cross-sector collaborations and advancing suicide prevention research, care, and policy both locally and nationally, we will develop cost-effective, practical, and efficient ways to implement evidence-based suicide prevention interventions. INSPIRE is poised to be transformational for suicide prevention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,617,817 )
2025	2025	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	002	5	8/20/2025	NON-COMPETING CONTINUATION	$2,617,817
2025	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	4	11/13/2024	NON-COMPETING CONTINUATION	$0
2025	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	001	4	7/29/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,617,817

Issue Date FY: 2024 ( Subtotal = $2,710,637 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	4	8/8/2024	NON-COMPETING CONTINUATION	$2,710,637
														Subtotal = $2,710,637

Issue Date FY: 2023 ( Subtotal = $2,818,204 )
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	3	7/28/2023	NON-COMPETING CONTINUATION	$2,818,204
														Subtotal = $2,818,204

Issue Date FY: 2022 ( Subtotal = $3,186,262 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	002	2	8/1/2022	NON-COMPETING CONTINUATION	$3,186,262
2022	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	001	1	3/23/2022	NEW	$0
2022	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	1	12/16/2021	NEW	$0
														Subtotal = $3,186,262

Issue Date FY: 2021 ( Subtotal = $3,074,419 )
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	1	9/10/2021	NEW	$3,074,419
														Subtotal = $3,074,419

Grand Total All Awards = $14,407,339

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Penn Innovation in Suicide Prevention Implementation Research (INSPIRE) Center

Award Number: P50MH127511

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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