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Laboratory for Early Psychosis Research (LEAP)

Award Number: P50MH115846
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Laboratory for Early Psychosis Research (LEAP) - 1. Abstract We propose to continue our existing NIMH P50 ALACRITY Center (Laboratory for Early Psychosis or LEAP Center). Although coordinated specialty care (CSC) is standard of care for patients with first episode psychosis (FEP), there remain gaps in our knowledge base regarding selection and deployment of treatments. The LEAP Center has been addressing these gaps through development of a statewide CSC clinic system in Massachusetts, standardized data collection and participation in the EPINET consortium, and adapting methods developed outside of mental health. In the first LEAP Center period, we have generated strong interdisciplinary collaborations between clinicians, policy makers/regulators, and stakeholders, and FEP experts from across the country plus scientific experts from outside of mental health, e.g., in data science, machine learning, epidemiology, and health policy. In the next period, we will leverage these collaborations to conduct a randomized clinical trial and to access diverse data sources to examine the role of specific treatment interventions in FEP. We also will apply and develop modern methods for clinical prediction and comparative effectiveness research (CER) for FEP research. We have three overall Center aims: 1) Collaborations; 2) Clinical research; and 3) Prediction and CER methods. The Center will include four complementary projects: 1) Project 1 is a “signature” project to conduct a cluster randomized clinical trial of enhanced CSC. 2) Project 2 will apply causal inference techniques on FEP-CAUSAL, an international data platform; 3) Project 3 will leverage EPINET national registry data to estimate the effect of treatment exposures studied in Project 1; 4) Project 4 will compare CSC care with non-CSC care at the state level using both electronic health record and statewide administrative datasets. The Administrative Core and Methods Core bind these projects and the multiple types of data (i.e., experimental data and observational data from electronic health records, national registries, or administrative datasets) and analytic approaches together. We have a group of Scientific Advisors, Center Faculty from diverse scientific disciplines (e.g., those that historically have had limited mental health research exposure), and Stakeholders (e.g., policy makers, organizational leaders, and patient and family advocates) who will be deeply involved in the Center from design to dissemination. The overall goal is to continue the evolution towards a state-wide learning health system for early psychosis which started in the first LEAP Center period and to continue to support NIMH-sponsored EPINET learning health system consortium.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	6	11/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,037,513 )
2024	2024	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	004	6	8/29/2024	NON-COMPETING CONTINUATION	$2,037,513
2024	2023	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	003	5	8/15/2024	COMPETING CONTINUATION	$0
2024	2023	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	002	5	8/1/2024	COMPETING CONTINUATION	$92,095
2024	2022	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	001	4	8/1/2024	SUPPLEMENT FOR EXPANSION	-$5,309
2024	2022	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	4	8/1/2024	NON-COMPETING CONTINUATION	-$86,785
														Subtotal = $2,037,513

Issue Date FY: 2023 ( Subtotal = $2,138,706 )
2023	2023	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	002	5	9/1/2023	COMPETING CONTINUATION	$2,138,706
2023	2022	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	001	4	8/28/2023	NON-COMPETING CONTINUATION	$0
2023	2022	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	4	2/17/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,138,706

Issue Date FY: 2022 ( Subtotal = $1,734,573 )
2022	2022	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	001	4	4/5/2022	NON-COMPETING CONTINUATION	$1,634,573
2022	2022	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	002	4	8/12/2022	SUPPLEMENT FOR EXPANSION	$100,000
2022	2021	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	3	11/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,734,573

Issue Date FY: 2021 ( Subtotal = $1,640,084 )
2021	2021	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	3	3/22/2021	NON-COMPETING CONTINUATION	$1,640,084
2021	2021	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	004	3	7/14/2021	NON-COMPETING CONTINUATION	$0
2021	2020	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	003	2	6/18/2021	NON-COMPETING CONTINUATION	$0
2021	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	002	1	6/17/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	001	1	6/16/2021	NEW	$0
														Subtotal = $1,640,084

Issue Date FY: 2020 ( Subtotal = $1,704,908 )
2020	2020	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	2	3/17/2020	NON-COMPETING CONTINUATION	$1,704,908
														Subtotal = $1,704,908

Issue Date FY: 2019 ( Subtotal = $1,788,124 )
2019	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	001	1	9/3/2019	SUPPLEMENT FOR EXPANSION	$320,161
2019	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	1	5/9/2019	NEW	$1,467,963
														Subtotal = $1,788,124

Grand Total All Awards = $11,043,908

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Laboratory for Early Psychosis Research (LEAP)

Award Number: P50MH115846

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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