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Fragmented early-life experiences, aberrant circuit maturation, emotional vulnerabilities

Award Number: P50MH096889
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/17/2013
PERIOD OF PERFORMANCE END DATE: 03/31/2025

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Fragmented early-life experiences, aberrant circuit maturation, emotional vulnerabilities - PROJECT SUMMARY Suicidal thoughts and behaviors (STBs) are the 5th leading cause of death among young children and non-fatal STBs account to close to half of emergency room visits in this age group. There is a dearth of research examining STBs among pre-adolescent children and a critical need for validated screening tools to identify children in need of intervention. Existing STB research tends to exclude individuals from marginalized backgrounds further limiting the generalizability of already sparse research in this population. Improving suicide prevention in children requires research innovation for this vulnerable group. There are three particularly critical barriers to identifying children at risk of STBs: 1) parental fears that STB assessment is iatrogenic; 2) lack of developmentally appropriate tools and methods for identifying child risk; and 3) lack of culturally appropriate and valid tools to address parent concerns and to identify child risk. This supplement in response to NOT-MH-22-195 directly addresses these barriers to identifying STBs in young children by leveraging an existing cohort of socioculturally and economically diverse mothers and their 5- to 8-year-old children, followed intensively from before birth with comprehensive assessments of cognitive and emotional development supported by a NIMH Conte Center grant (P50 MH096889). Incorporating critical community perspectives, this supplement tests the following aims: 1. Provide developmentally and culturally appropriate methods for assessing and quantifying STBs in 5- to 8-year- old children; 2. Test the efficacy of a brief informational intervention to increase parent consent to probe STBs in 5- to 8-year-old children; 3. Validate/implement novel instruments for STB assessment capitalizing on a thoroughly characterized and culturally diverse cohort. The discoveries generated by this project address critical gaps in the development of tools to accurately assess STBs in young children in need of life saving intervention. Further, the proposed supplement falls within, and enriches, the scope of the parent grant. The parent grant investigates early origins of anhedonia and as STBs often accompany or follow anhedonia, this supplement provides an important complementary outcome measure. Additionally, the parent grant probes the role of unpredictable early life experiences in psychopathology and Aim 3 of the supplement enables assessment of the role of unpredictability in STBs. The present study has the potential to transform the study of STBs in children, by enhancing parent consent to assessment of STBs and increasing confidence in the validity of STB assessment in children.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$1 )
2025	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	000	10	6/25/2025	NON-COMPETING CONTINUATION	-$1
2025	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	001	10	6/25/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = -$1

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	000	10	3/14/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $3,179,609 )
2023	2023	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	000	10	6/8/2023	NON-COMPETING CONTINUATION	$2,918,686
2023	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	001	10	9/12/2023	SUPPLEMENT FOR EXPANSION	$260,923
														Subtotal = $3,179,609

Issue Date FY: 2022 ( Subtotal = $2,917,852 )
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	002	9	3/22/2022	NON-COMPETING CONTINUATION	$2,931,489
2022	2021	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	001	8	3/7/2022	NON-COMPETING CONTINUATION	$0
2022	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	000	7	2/21/2022	NON-COMPETING CONTINUATION	-$13,637
														Subtotal = $2,917,852

Issue Date FY: 2021 ( Subtotal = $2,949,554 )
2021	2021	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	000	8	3/29/2021	NON-COMPETING CONTINUATION	$2,949,554
														Subtotal = $2,949,554

Issue Date FY: 2020 ( Subtotal = $3,136,245 )
2020	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	000	7	6/8/2020	NON-COMPETING CONTINUATION	$2,979,997
2020	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	001	7	9/16/2020	SUPPLEMENT FOR EXPANSION	$156,248
														Subtotal = $3,136,245

Issue Date FY: 2019 ( Subtotal = $3,020,227 )
2019	2019	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	002	6	8/15/2019	COMPETING CONTINUATION	$4,074
2019	2019	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	000	6	5/31/2019	COMPETING CONTINUATION	$3,020,227
2019	2017	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	001	5	8/15/2019	NON-COMPETING CONTINUATION	-$4,074
														Subtotal = $3,020,227

Issue Date FY: 2017 ( Subtotal = $2,000,000 )
2017	2017	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	002	5	5/5/2017	NON-COMPETING CONTINUATION	$1,799,999
2017	2017	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	005	5	8/18/2017	NON-COMPETING CONTINUATION	$200,001
2017	2016	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	004	4	6/5/2017	EXTENSION WITH OR WITHOUT FUNDS	$4,073
2017	2016	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	001	4	11/1/2016	EXTENSION WITH OR WITHOUT FUNDS	$163,447
2017	2015	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	000	3	11/1/2016	NON-COMPETING CONTINUATION	-$163,447
2017	2015	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Mental Health Research Grants	003	3	6/5/2017	NON-COMPETING CONTINUATION	-$4,073
														Subtotal = $2,000,000

Issue Date FY: 2016 ( Subtotal = $2,171,541 )
2016	2016	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	001	4	6/25/2016	SUPPLEMENT FOR EXPANSION	$171,541
2016	2016	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	000	4	4/22/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,000,000
														Subtotal = $2,171,541

Issue Date FY: 2015 ( Subtotal = $2,000,000 )
2015	2015	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	000	3	5/1/2015	NON-COMPETING CONTINUATION	$2,000,000
														Subtotal = $2,000,000

Issue Date FY: 2014 ( Subtotal = $2,000,000 )
2014	2014	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	000	2	5/12/2014	NON-COMPETING CONTINUATION	$2,000,000
														Subtotal = $2,000,000

Issue Date FY: 2013 ( Subtotal = $2,000,000 )
2013	2013	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	000	1	6/17/2013	NEW	$2,000,000
														Subtotal = $2,000,000

Grand Total All Awards = $25,375,027

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Fragmented early-life experiences, aberrant circuit maturation, emotional vulnerabilities

Award Number: P50MH096889

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/17/2013

PERIOD OF PERFORMANCE END DATE: 03/31/2025

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