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Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE)

Award Number: P50ES026049
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2015
PERIOD OF PERFORMANCE END DATE: 06/30/2021

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Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE) - DESCRIPTION (provided by applicant): Exposure to multiple chemicals in the environment during critical fetal and childhood development periods is an important yet understudied area of public health, particularly when coupled with psychosocial risk factors that may modify the effects of these exposures. To address this gap, the Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE) will study the impact of a mixture of environmental exposures and modifying factors on fetal and early childhood health and development in the children of the heavily-contaminated northern coast of Puerto Rico, an underserved, highly-exposed, and low-income population with significant health disparities. To achieve this timely and significant goal, CRECE has developed an innovative and scientifically distinct program that leverages the ongoing cohort study of the PROTECT NIEHS Superfund Research Center; this cohort is following 1800 pregnant Puerto Rican women through childbirth to investigate the relationship between groundwater contamination and the island's extremely high preterm birth rate. CRECE will initiate a follow-up study of 600 infants born to the PROTECT cohort, for whom a rich prenatal dataset and biological samples already exists, following them from birth to age four. Through a unique and holistic source-to-outcome strategy incorporating three interrelated and transdisciplinary research projects and three cores, CRECE will 1) capture the impacts of pollutant exposures (both alone and in combination) that occur through multiple exposure routes and biological pathways on fetal and early childhood health and development, 2) evaluate how psychosocial risk factors (e.g. socioeconomic status and maternal stress) may modify these effects, and 3) elucidate biological mechanisms that may explain mechanistic pathways and mediate these relationships. The CRECE interdisciplinary team includes environmental epidemiologists, pediatricians, environmental scientists/engineers, exposure scientists, sociologists, social workers, biostatisticians, toxicologists, and communication neuroscientists (many of whom have previously collaborated through PROTECT). CRECE will answer important research questions: What are the combined effects of intrauterine and early childhood exposure to multiple pollutants on children's health and development in a highly exposed population? What are the mechanisms by which these effects occur? How do psychosocial factors modify the effects of environmental chemical exposures? Can exposure biomarkers be developed to capture multi- pollutant and multi-pathway exposures for health effect investigations? The answers to these questions, along with the innovative tools and methods developed to answer them, will advance the science of children's environmental health by improving our understanding of the effects of the total environment on at-risk as well as general populations with multiple exposures. The proposed work will inform future clinical intervention, risk assessment, and policy-setting efforts for both this at-risk, vulnerable population and the U.S. as a whole.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2018	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Environmental Health	000	4	11/27/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Environmental Health	000	4	7/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Environmental Health	000	4	2/25/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $1,300,488 )
2018	2018	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Environmental Health	001	4	9/20/2018	SUPPLEMENT FOR EXPANSION	$725,488
2018	2018	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Environmental Health	000	4	7/10/2018	NON-COMPETING CONTINUATION	$575,000
														Subtotal = $1,300,488

Issue Date FY: 2017 ( Subtotal = $725,000 )
2017	2017	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Environmental Health	000	3	6/29/2017	NON-COMPETING CONTINUATION	$725,000
														Subtotal = $725,000

Issue Date FY: 2016 ( Subtotal = $775,000 )
2016	2016	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Environmental Health	000	2	7/19/2016	NON-COMPETING CONTINUATION	$775,000
														Subtotal = $775,000

Issue Date FY: 2015 ( Subtotal = $825,000 )
2015	2015	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Environmental Health	000	1	9/8/2015	NEW	$825,000
														Subtotal = $825,000

Grand Total All Awards = $3,625,488

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Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE)

Award Number: P50ES026049

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2015

PERIOD OF PERFORMANCE END DATE: 06/30/2021

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