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Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction

Award Number: P50DC015446
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2017
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction - Project Summary/Abstract Vocal hyperfunction (VH) is associated with the most frequently occurring types of voice disorders. These include benign vocal folds lesions (e.g., nodules and polyps) and dysphonia that occurs in the absence of concurrent pathology (e.g., muscle tension dysphonia). Effective prevention and clinical management of these disorders continue to be hampered by limited knowledge of the etiological and pathophysiological mechanisms that underlie specific voice disorders within the broad range of those associated with VH. To address this need, this Clinical Research Center brings together a multidisciplinary team of experienced investigators to pursue a comprehensive program of research focused on hyperfunctional voice disorders. The central theme of the Center is that the clinical management of hyperfunctional voice disorders can be significantly improved by attaining a better understanding of the etiology and pathophysiology of these disorders and then translating this knowledge into new, more effective methods for prevention, diagnosis, and treatment. A central premise of this work is that multiple factors contribute and interact in different ways to cause and maintain the various disorders linked to VH. The most important are associated with behavioral, sensorimotor, environmental, psychological/emotional, physiological, and biomechanical mechanisms. The interdisciplinary research program will focus on attaining a comprehensive understanding of the fundamental relationships between these factors and the different manifestations of VH. Research at the Center is guided and coordinated by a comprehensive theoretical framework for VH that clearly illustrates the key hypotheses that will be assessed in a coordinated effort overseen by an Administrative Core and carried out by the four Research Projects and Technology and Data Science Core. Projects will employ an innovative combination of laboratory studies of sensorimotor and physiological mechanisms; physical and computational modeling of biomechanical, aero- acoustic, and auditory-motor control mechanisms; and the use of improved ambulatory voice monitoring technology to investigate potential etiological and pathophysiological mechanisms of VH associated with daily voice use. A clinical trial will also assess the benefit of combining novel ambulatory biofeedback with evidence- based voice therapy to treat VH. A significant strength of the Center will be a centralized multidimensional database in the Technology and Data Science Core that receives comprehensive data from all of the projects for all enrolled patients and healthy controls, thus greatly facilitating the integration of results across the projects and magnifying the impact of the Center well beyond the sum of its parts. This program of research in hyperfunctional voice disorders is unprecedented in terms of its scope, integration of information across multiple domains, number of innovative concepts, and methods that are being simultaneously developed and tested. Achieving the goals of this research program will significantly improve the prevention and clinical management of these highly prevalent disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,856,494 )
2026	2026	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	9	4/13/2026	NON-COMPETING CONTINUATION	$2,634,779
2026	2026	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	9	4/28/2026	SUPPLEMENT FOR EXPANSION	$154,774
2026	2026	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	003	9	5/11/2026	NON-COMPETING CONTINUATION	$0
2026	2026	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	9	4/27/2026	SUPPLEMENT FOR EXPANSION	$66,941
														Subtotal = $2,856,494

Issue Date FY: 2025 ( Subtotal = $2,849,071 )
2025	2025	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	8	4/21/2025	NON-COMPETING CONTINUATION	$284,907
2025	2025	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	8	4/3/2025	NON-COMPETING CONTINUATION	$2,564,164
2025	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	7	12/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,849,071

Issue Date FY: 2024 ( Subtotal = $2,882,399 )
2024	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	003	7	4/5/2024	NON-COMPETING CONTINUATION	$2,882,399
2024	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	6	1/15/2024	COMPETING CONTINUATION	$0
2024	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	6	4/3/2024	COMPETING CONTINUATION	$72,655
2024	2021	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	5	4/3/2024	NON-COMPETING CONTINUATION	-$72,655
														Subtotal = $2,882,399

Issue Date FY: 2023 ( Subtotal = $2,989,995 )
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	6	4/19/2023	COMPETING CONTINUATION	$0
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	003	6	8/3/2023	COMPETING CONTINUATION	$0
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	6	6/26/2023	COMPETING CONTINUATION	$0
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	6	4/17/2023	COMPETING CONTINUATION	$2,989,995
														Subtotal = $2,989,995

Issue Date FY: 2021 ( Subtotal = $2,198,264 )
2021	2021	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	5	3/24/2021	NON-COMPETING CONTINUATION	$2,198,264
2021	2021	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	5	9/13/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,198,264

Issue Date FY: 2020 ( Subtotal = $2,234,215 )
2020	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	4	9/25/2020	NON-COMPETING CONTINUATION	$0
2020	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	4	3/26/2020	NON-COMPETING CONTINUATION	$2,234,215
														Subtotal = $2,234,215

Issue Date FY: 2019 ( Subtotal = $2,246,101 )
2019	2019	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	3	9/4/2019	NON-COMPETING CONTINUATION	$0
2019	2019	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	3	3/21/2019	NON-COMPETING CONTINUATION	$2,246,101
														Subtotal = $2,246,101

Issue Date FY: 2018 ( Subtotal = $2,229,852 )
2018	2018	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	2	8/30/2018	NON-COMPETING CONTINUATION	$0
2018	2018	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	2	4/6/2018	NON-COMPETING CONTINUATION	$222,985
2018	2018	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	2	3/29/2018	NON-COMPETING CONTINUATION	$2,006,867
														Subtotal = $2,229,852

Issue Date FY: 2017 ( Subtotal = $2,397,233 )
2017	2017	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	1	3/23/2017	NEW	$2,397,233
														Subtotal = $2,397,233

Grand Total All Awards = $22,883,624

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Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction

Award Number: P50DC015446

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2017

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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