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Specialized Program Of Research Excellence (SPORE) in Leukemia.

Award Number: P50CA171963
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT The Washington University SPORE in Leukemia is a highly dynamic translational cancer research program that focuses specifically on leukemias and myelodysplastic syndromes (MDS). We have assembled an outstanding group of investigators with complementary expertise in basic and clinical leukemia research. In this SPORE, we leverage expertise in cancer genomics, immunology, and hematopoiesis to develop innovative translational research in leukemia. Our long-term goal is to develop novel biomarkers and treatments for leukemias and myelodysplastic syndromes and to develop and promote innovative translational leukemia research. To achieve these goals, the following specific aims are proposed. Aim 1. We will exploit institutional expertise in cancer genomics, immunology, and hematopoiesis to develop novel biomarkers and treatments for leukemias and myelodysplastic syndromes. Basic research at WUSM has led to the development of the following five translational research projects, all featuring innovative investigator-initiated therapeutic trials for leukemias or MDS. · Project 1. Molecular determinants of decitabine responsiveness · Project 2. Targeted therapies for T cell acute lymphoblastic leukemia (T-ALL) · Project 3. Novel therapies for splicesome-mutant MDS · Project 4. Bi-specific antibody-based therapies for AML · Project 5. Memory-like NK cell augmented hematopoietic cell transplantation for AML Aim 2. We will enhance the infrastructure that supports translational leukemia research. This SPORE will support the following Shared Research Resources: 1) Core A. Biospecimen Processing; 2) Core B. Biostatistics; and 3) Core C. Administration. Aim 3. We will recruit and train new investigators in translational research. This SPORE will support a Career Enhancement Program (CEP) to recruit and mentor new investigators in translational leukemia research. The SPORE has established a successful minority post-baccalaureate training program. The SPORE also will support a Developmental Research Program (DRP) to support innovative translational concepts. Aim 4. We will facilitate inter-SPORE collaboration. Four of the SPORE projects include multi-institutional clinical trials, including three at other Leukemia SPORE institutions. We have established CEP educational exchange and grant review programs with peer Leukemia SPORE institutions. We will continue to organize and participate in joint meetings of Leukemia SPOREs at MD Anderson and Harvard.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $918,606 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	001	10	9/20/2023	SUPPLEMENT FOR EXPANSION	$918,606
2023	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	000	10	4/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $918,606

Issue Date FY: 2022 ( Subtotal = $2,127,879 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	003	10	9/21/2022	NON-COMPETING CONTINUATION	$46,000
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	001	10	7/1/2022	NON-COMPETING CONTINUATION	$2,242,879
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	002	10	7/19/2022	NON-COMPETING CONTINUATION	-$161,000
2022	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	000	9	2/1/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,127,879

Issue Date FY: 2021 ( Subtotal = $2,035,962 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	002	9	6/28/2021	NON-COMPETING CONTINUATION	$2,035,962
2021	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	000	8	3/2/2021	NON-COMPETING CONTINUATION	$0
2021	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	001	8	4/23/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,035,962

Issue Date FY: 2020 ( Subtotal = $2,184,998 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	001	8	6/16/2020	NON-COMPETING CONTINUATION	$2,184,998
2020	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	000	7	2/24/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,184,998

Issue Date FY: 2019 ( Subtotal = $2,122,870 )
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	005	7	6/20/2019	NON-COMPETING CONTINUATION	$2,117,606
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	006	7	7/2/2019	SUPPLEMENT FOR EXPANSION	$5,264
2019	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	003	6	11/29/2018	COMPETING CONTINUATION	$368
2019	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	004	6	1/14/2019	COMPETING CONTINUATION	$0
2019	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	001	6	11/9/2018	COMPETING CONTINUATION	$46,186
2019	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	002	5	11/29/2018	SUPPLEMENT FOR EXPANSION	-$368
2019	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	000	5	11/9/2018	SUPPLEMENT FOR EXPANSION	-$46,186
														Subtotal = $2,122,870

Issue Date FY: 2018 ( Subtotal = $2,366,162 )
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	002	6	9/12/2018	COMPETING CONTINUATION	-$1
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	001	6	9/11/2018	SUPPLEMENT FOR EXPANSION	$66,323
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	000	6	8/6/2018	COMPETING CONTINUATION	$2,299,840
														Subtotal = $2,366,162

Issue Date FY: 2017 ( Subtotal = $2,431,282 )
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	005	5	8/28/2017	SUPPLEMENT FOR EXPANSION	$60,753
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	003	5	6/30/2017	NON-COMPETING CONTINUATION	$2,185,000
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	008	5	9/20/2017	NON-COMPETING CONTINUATION	$115,000
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	004	5	7/11/2017	SUPPLEMENT FOR EXPANSION	$5,201
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	006	5	8/30/2017	SUPPLEMENT FOR EXPANSION	$63,041
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	007	5	9/11/2017	SUPPLEMENT FOR EXPANSION	$2,287
2017	2016	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	002	4	11/7/2016	EXTENSION WITH OR WITHOUT FUNDS	$57,758
2017	2015	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	001	3	11/7/2016	SUPPLEMENT FOR EXPANSION	-$55,795
2017	2015	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Centers Support Grants	000	3	11/7/2016	NON-COMPETING CONTINUATION	-$1,963
														Subtotal = $2,431,282

Issue Date FY: 2016 ( Subtotal = $2,223,802 )
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Cancer Centers Support Grants	000	4	6/30/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,162,000
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Cancer Centers Support Grants	001	4	9/15/2016	SUPPLEMENT FOR EXPANSION	$61,802
														Subtotal = $2,223,802

Issue Date FY: 2015 ( Subtotal = $2,239,738 )
2015	2015	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Cancer Centers Support Grants	001	3	6/29/2015	SUPPLEMENT FOR EXPANSION	$55,795
2015	2015	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Cancer Centers Support Grants	000	3	6/17/2015	NON-COMPETING CONTINUATION	$2,183,943
														Subtotal = $2,239,738

Issue Date FY: 2014 ( Subtotal = $2,161,999 )
2014	2014	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Cancer Centers Support Grants	001	2	8/12/2014	NON-COMPETING CONTINUATION	$782,001
2014	2014	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Cancer Centers Support Grants	000	2	7/8/2014	NON-COMPETING CONTINUATION	$1,379,998
														Subtotal = $2,161,999

Issue Date FY: 2013 ( Subtotal = $2,151,000 )
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Cancer Centers Support Grants	000	1	9/3/2013	NEW	$2,151,000
														Subtotal = $2,151,000

Grand Total All Awards = $22,964,298

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Specialized Program Of Research Excellence (SPORE) in Leukemia.

Award Number: P50CA171963

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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