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Roswell Park Ovarian Cancer SPORE

Award Number: P50CA159981
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/18/2013
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Roswell Park Ovarian Cancer SPORE - OVERALL SUMMARY – Roswell Park-University of Chicago Ovarian Cancer SPORE This is the revised competing renewal application of the Roswell Park-University of Chicago Ovarian Cancer SPORE. We have made significant progress on the translational objectives and human endpoints of each Individual Research Project (IRP). Our highly successful Developmental Research Program (DRP) and Career Enhancement Program (CEP) have catalyzed new translational ovarian cancer research projects, collaborations, and extramural funding for awardees. Our overarching goal remains unchanged: to conduct multidisciplinary, mechanism-based and collaborative translational research that will have the highest possible impact for patients with ovarian cancer. Because immunotherapies have met with only modest success in ovarian cancer patients, we continue to uniquely focus on novel strategies for generating effective anti-tumor immunity by unraveling immune-resistance mechanisms and identifying novel proteogenomic biomarkers of responsiveness. After significant planning and guidance by our Internal and External Advisory Boards, and Patient Advocate Committee, we have leveraged our highly successful DRP and CEP to propose two bi-directional translational IRPs addressing basic and clinical research questions of importance in ovarian cancer. The new IRP1 evolved as a result of a DRP award and the new IRP2 developed from a CEP award. IRP1 will test an oncolytic virus armed with a CXCR4 antagonist in combination with PDL1 blockade to abrogate tumor immune suppression and limit T cell exhaustion in a randomized Phase I/II clinical trial. IRP2 addresses the completely novel concept of identifying mismatch between immunopeptidomes of ovarian cancer cells versus dendritic cells and leveraging a computational approach of bypassing such mismatch. IRP1 commences with a planned clinical trial; the Phase I/II clinical trial in IRP2 will commence in year 3 following preclinical, IND-enabling translational studies. The program also continues to expand opportunities for new avenues of ovarian cancer translational research via its successful DRP and CEP. The four highly integrated, interconnected shared resource cores – Administration, Biospecimen & Pathology, Biostatistics & Bioinformatics, and Immunogenomics – bring innovative technology and resources to the SPORE and do not duplicate pre-existing shared resources available at Roswell Park or the University of Chicago. This application is strongly supported by over $3.6MM of institutional commitment to ensure its success of conducting highly innovative translational research that changes the clinical practice paradigm in ovarian cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,787,915 )
2025	2025	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	001	11	9/10/2025	NON-COMPETING CONTINUATION	$1,787,915
2025	2024	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	000	10	12/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,787,915

Issue Date FY: 2024 ( Subtotal = $1,745,539 )
2024	2024	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	003	10	7/29/2024	NON-COMPETING CONTINUATION	$1,745,539
2024	2023	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	002	9	3/21/2024	NON-COMPETING CONTINUATION	$0
2024	2023	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	001	9	3/18/2024	NON-COMPETING CONTINUATION	$0
2024	2023	HEALTH RESEARCH, INC.	ELM & CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	000	9	11/9/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,745,539

Issue Date FY: 2023 ( Subtotal = $1,147,484 )
2023	2023	HEALTH RESEARCH, INC.	ELM & CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	001	9	8/1/2023	NON-COMPETING CONTINUATION	$1,147,484
2023	2022	HEALTH RESEARCH, INC.	ELM & CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	000	8	5/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,147,484

Issue Date FY: 2022 ( Subtotal = $1,532,970 )
2022	2022	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	002	8	8/26/2022	NON-COMPETING CONTINUATION	$1,497,487
2022	2022	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	003	8	9/22/2022	NON-COMPETING CONTINUATION	$35,483
2022	2021	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	001	7	7/8/2022	COMPETING CONTINUATION	$116,979
2022	2018	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	000	6	7/8/2022	NON-COMPETING CONTINUATION	-$116,979
														Subtotal = $1,532,970

Issue Date FY: 2021 ( Subtotal = $1,716,101 )
2021	2021	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	001	7	8/23/2021	COMPETING CONTINUATION	$1,716,101
2021	2018	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	000	6	4/13/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,716,101

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	000	6	8/10/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	000	6	2/18/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $1,750,206 )
2018	2018	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	000	6	6/29/2018	NON-COMPETING CONTINUATION	$1,750,206
2018	2017	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	001	5	7/16/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,750,206

Issue Date FY: 2017 ( Subtotal = $2,354,957 )
2017	2017	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	005	5	9/21/2017	NON-COMPETING CONTINUATION	$115,000
2017	2017	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	003	5	7/10/2017	NON-COMPETING CONTINUATION	$2,185,000
2017	2017	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	004	5	9/6/2017	SUPPLEMENT FOR EXPANSION	$54,957
2017	2016	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	002	4	1/4/2017	EXTENSION WITH OR WITHOUT FUNDS	$1,420,307
2017	2015	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	000	3	1/4/2017	NON-COMPETING CONTINUATION	-$1,353,549
2017	2015	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Centers Support Grants	001	3	1/4/2017	SUPPLEMENT FOR EXPANSION	-$66,758
														Subtotal = $2,354,957

Issue Date FY: 2016 ( Subtotal = $1,028,849 )
2016	2016	HEALTH RESEARCH, INC - ROSWELL PARK DIVISION	666 ELM STREET	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	002	4	9/14/2016	SUPPLEMENT FOR EXPANSION	$550,298
2016	2016	HEALTH RESEARCH, INC - ROSWELL PARK DIVISION	666 ELM STREET	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	000	4	6/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$411,793
2016	2016	HEALTH RESEARCH, INC - ROSWELL PARK DIVISION	666 ELM STREET	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	001	4	7/5/2016	SUPPLEMENT FOR EXPANSION	$66,758
														Subtotal = $1,028,849

Issue Date FY: 2015 ( Subtotal = $2,194,758 )
2015	2015	HEALTH RESEARCH, INC - ROSWELL PARK DIVISION	666 ELM STREET	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	000	3	7/16/2015	NON-COMPETING CONTINUATION	$2,128,000
2015	2015	HEALTH RESEARCH, INC - ROSWELL PARK DIVISION	666 ELM STREET	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	001	3	8/6/2015	SUPPLEMENT FOR EXPANSION	$66,758
														Subtotal = $2,194,758

Issue Date FY: 2014 ( Subtotal = $2,162,000 )
2014	2014	HEALTH RESEARCH, INC - ROSWELL PARK DIVISION	666 ELM STREET	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	000	2	8/28/2014	NON-COMPETING CONTINUATION	$2,162,000
														Subtotal = $2,162,000

Issue Date FY: 2013 ( Subtotal = $2,150,500 )
2013	2013	HEALTH RESEARCH, INC - ROSWELL PARK DIVISION	666 ELM STREET	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	000	1	9/18/2013	NEW	$2,150,500
														Subtotal = $2,150,500

Grand Total All Awards = $19,571,279

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Roswell Park Ovarian Cancer SPORE

Award Number: P50CA159981

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/18/2013

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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