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Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer

Award Number: P50CA127003
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2007
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer - Project Summary This is a competitive renewal application for a SPORE in Gastrointestinal (GI) Cancers originating from the GI Malignancies Program of the Dana-Farber/Harvard Cancer Center (DF/HCC). Since its inception in 2007, the SPORE has established a thriving culture of inter-institutional collaboration that has united basic, clinical, and population scientists into a highly productive translational enterprise. The ability to attract and retain researchers from diverse disciplines has fostered fundamental discoveries in cancer biology, innovative translational hypotheses, and cutting-edge clinical trials. The SPORE has also maintained a central focus on developing a large cadre of new investigators, building on a successful model of interdisciplinary, cross- campus cooperation that serves as a nidus for inter-SPORE relationships and other collaborations. Moreover, the SPORE has created invaluable research resources, such as the Tissue, PDX and Organoid Repository and clinical, pathology, and genomics databases that collectively accelerate translational investigation. Each of the current projects has achieved or exceeded its translational goals, providing a foundation for programmatic studies, including independent large-scale collaborative initiatives. Building on this progress, the DF/HCC GI SPORE seeks to continue to translate biological and technological advances into improvements in the prevention and treatment of GI malignancies. The overarching objectives of a renewed SPORE are to: 1) Define optimal genomic and functional strategies, including integration of cell-free (cf)DNA profiling (Projects 1-4), to predict drug responsiveness and improve diagnostics, prognostics, and clinical decisions. 2) Elucidate the interplay between oncogenic mutations, targeted therapy, and anti-tumor immunity to inform cancer biology and improve the outcome of patients with GI cancers (Projects 1,3, 4). 3) Define mechanisms of resistance to novel targeted therapies and hence identify new approaches to overcome resistance and better select the patients most likely to respond to therapy (Projects 1-4). 4) Enhance study of deadly GI cancers that, despite rising incidence, remain under- studied (Project 2, 4). 5) Encourage collaboration and promote academic rigor by providing clinical specimens, fostering core technologies and resources, and hosting regular research meetings and seminars focused on GI cancers. 6) Provide mentorship and training for young GI cancer researchers and recruit leading translational investigators from other fields through Career Enhancement and Developmental Project Awards.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	15	3/14/2024	NON-COMPETING CONTINUATION	$0
2024	2023	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	001	15	5/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $2,248,301 )
2023	2023	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	002	15	6/30/2023	NON-COMPETING CONTINUATION	$2,248,301
2023	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	14	4/18/2023	NON-COMPETING CONTINUATION	$0
2023	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	14	1/10/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,248,301

Issue Date FY: 2022 ( Subtotal = $2,157,311 )
2022	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	002	14	9/21/2022	NON-COMPETING CONTINUATION	$48,482
2022	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	14	7/22/2022	NON-COMPETING CONTINUATION	$2,108,829
2022	2021	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	13	3/10/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,157,311

Issue Date FY: 2021 ( Subtotal = $1,547,949 )
2021	2021	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	13	7/23/2021	NON-COMPETING CONTINUATION	$1,547,949
2021	2020	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	12	2/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,547,949

Issue Date FY: 2020 ( Subtotal = $2,237,511 )
2020	2020	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	002	12	8/24/2020	NON-COMPETING CONTINUATION	$2,237,511
2020	2019	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	11	12/2/2019	COMPETING CONTINUATION	$66,827
2020	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	10	12/2/2019	NON-COMPETING CONTINUATION	-$66,827
														Subtotal = $2,237,511

Issue Date FY: 2019 ( Subtotal = $2,450,827 )
2019	2019	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	11	8/30/2019	COMPETING CONTINUATION	$2,450,827
2019	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	10	8/27/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,450,827

Issue Date FY: 2017 ( Subtotal = $2,293,187 )
2017	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	002	10	7/10/2017	NON-COMPETING CONTINUATION	$2,178,185
2017	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	003	10	9/21/2017	NON-COMPETING CONTINUATION	$115,002
2017	2016	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	9	12/7/2016	EXTENSION WITH OR WITHOUT FUNDS	$187,614
2017	2015	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	8	12/7/2016	NON-COMPETING CONTINUATION	-$187,614
														Subtotal = $2,293,187

Issue Date FY: 2016 ( Subtotal = $2,162,000 )
2016	2016	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	9	7/15/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,162,000
														Subtotal = $2,162,000

Issue Date FY: 2015 ( Subtotal = $2,185,000 )
2015	2015	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	8	7/17/2015	NON-COMPETING CONTINUATION	$2,185,000
														Subtotal = $2,185,000

Issue Date FY: 2014 ( Subtotal = $2,152,672 )
2014	2014	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	7	8/25/2014	NON-COMPETING CONTINUATION	$2,152,672
														Subtotal = $2,152,672

Issue Date FY: 2013 ( Subtotal = $2,150,500 )
2013	2013	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	6	9/23/2013	COMPETING CONTINUATION	$2,150,500
														Subtotal = $2,150,500

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2011	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	5	4/9/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $2,185,000 )
2011	2011	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	5	9/1/2011	NON-COMPETING CONTINUATION	$2,185,000
														Subtotal = $2,185,000

Issue Date FY: 2010 ( Subtotal = $2,496,835 )
2010	2010	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	002	4	8/25/2010	NON-COMPETING CONTINUATION	$2,409,374
2010	2009	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	3	10/30/2009	NON-COMPETING CONTINUATION	$87,461
2010	2009	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	3	10/30/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,496,835

Issue Date FY: 2009 ( Subtotal = $2,387,462 )
2009	2009	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	3	9/29/2009	NON-COMPETING CONTINUATION	$87,461
2009	2009	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	3	6/22/2009	NON-COMPETING CONTINUATION	$2,300,001
														Subtotal = $2,387,462

Issue Date FY: 2008 ( Subtotal = $2,300,001 )
2008	2008	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	2	7/18/2008	NON-COMPETING CONTINUATION	$2,300,001
														Subtotal = $2,300,001

Issue Date FY: 2007 ( Subtotal = $2,300,001 )
2007	2007	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	1	8/30/2007	NEW	$2,300,001
														Subtotal = $2,300,001

Grand Total All Awards = $33,254,557

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Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer

Award Number: P50CA127003

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2007

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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