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City of Hope Lymphoma SPORE

Award Number: P50CA107399
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/02/2004
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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City of Hope Lymphoma SPORE - The overall goal of the City of Hope Lymphoma SPORE is to develop novel therapeutics and prognostics representing the forefront of knowledge gained from observations in molecular biology and cellular immunology at City of Hope. Six clinical trials are proposed, five of which utilize agents (cellular products, small molecules, radiolabeled antibodies) that have been produced at City of Hope and are developed from our preclinical laboratory studies. In Project 1, we have engineered bi-specific chimeric antigen receptor (CAR) T cells that respond to both lymphoma antigen and cytomegalovirus (CMV) antigen. Combining bi-specific CAR T cells with a CMV vaccine developed at City of Hope may enhance CAR T cell persistence and allow in vivo control of T cells in patients with relapsed/refractory non-Hodgkin lymphoma (NHL) in three clinical settings: 1) lymphodepleting chemotherapy, 2) autologous (auto) hematopoietic cell transplantation (HCT), and 3) allogeneic HCT. Project 2 builds on our previous observations in a prospective longitudinal study of lymphoma patients undergoing auto HCT, revealing pathogenic mutations contributing to a predictive 38-gene signature of susceptibility to tMDS/AML. We will now use this City of Hope cohort and an external validation cohort to develop a comprehensive risk prediction model for developing t-MDS/AML after auto HCT. Project 3 addresses the poor outcomes for patients with relapsed Hodgkin lymphoma with two phase II clinical trials: a PET-adapted strategy using PD-1 inhibitor nivolumab ± ICE chemotherapy as a bridge to autologous HCT, and aTac-BEAM, a radioimmunotherapy-based augmented autologous HCT regimen. In Project 4, we propose a clinical trial of a novel agent linking a CpG oligonucleotide with anti-sense STAT3 siRNA to target NHL and associated immune cells. We are also developing a modified high-affinity STAT3-DNA binding sequence linked to a CpG oligonucleotide that inhibits STAT3 by acting as DNA decoy. The SPORE, also supports a Career Enhancement Program for researchers new to lymphoma research, as well as a Developmental Research Program for scientists with promising pilot projects. SPORE cores provide crucial support to the success of the projects: The Administrative Core (Core A) provides organizational and programmatic support; the Biostatistics and Research Informatics Core (Core B) imparts comprehensive statistical and information management expertise; and Biospecimen Core (Core C) supports projects as they relate to sample collection, processing, storage and distribution. The GMP Manufacturing Core (Core D) is responsible for process development, regulatory support, and cGMP-compliant clinical grade production of novel investigational agents; this core is an invaluable resource allowing us to rapidly translate laboratory discoveries to the clinic. Lastly, with a richly diverse catchment area, City of Hope has made a coordinated effort to engage patients that have been traditionally underrepresented and underserved in clinical trials. In sum, this SPORE holds high potential to make significant inroads in improving outcomes for lymphoma patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	15	9/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	15	3/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $2,307,384 )
2022	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	002	15	8/15/2022	NON-COMPETING CONTINUATION	$2,257,764
2022	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	003	15	9/22/2022	NON-COMPETING CONTINUATION	$49,620
2022	2021	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	001	14	6/6/2022	NON-COMPETING CONTINUATION	$0
2022	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	000	13	1/18/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,307,384

Issue Date FY: 2021 ( Subtotal = $2,324,819 )
2021	2021	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	001	14	7/26/2021	NON-COMPETING CONTINUATION	$2,324,819
2021	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	13	3/12/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,324,819

Issue Date FY: 2020 ( Subtotal = $2,535,066 )
2020	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	003	13	9/10/2020	SUPPLEMENT FOR EXPANSION	$176,000
2020	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	004	13	9/15/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	001	13	8/19/2020	NON-COMPETING CONTINUATION	$2,359,066
2020	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	002	13	8/27/2020	NON-COMPETING CONTINUATION	$0
2020	2019	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	12	3/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,535,066

Issue Date FY: 2019 ( Subtotal = $2,324,999 )
2019	2019	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	004	12	8/19/2019	NON-COMPETING CONTINUATION	$2,324,999
2019	2018	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	002	11	4/11/2019	COMPETING CONTINUATION	$0
2019	2018	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	003	11	4/30/2019	COMPETING CONTINUATION	$0
2019	2017	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	001	10	3/25/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2015	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	10	3/25/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,324,999

Issue Date FY: 2018 ( Subtotal = $2,500,000 )
2018	2018	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	11	7/31/2018	COMPETING CONTINUATION	$2,500,000
														Subtotal = $2,500,000

Issue Date FY: 2017 ( Subtotal = $300,000 )
2017	2017	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	002	10	9/21/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2017	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	10	9/11/2017	SUPPLEMENT FOR EXPANSION	$300,000
2017	2015	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	001	10	9/20/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $300,000

Issue Date FY: 2015 ( Subtotal = $2,185,000 )
2015	2015	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	10	8/13/2015	NON-COMPETING CONTINUATION	$2,185,000
														Subtotal = $2,185,000

Issue Date FY: 2014 ( Subtotal = $2,162,001 )
2014	2014	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	9	8/14/2014	NON-COMPETING CONTINUATION	$2,162,001
														Subtotal = $2,162,001

Issue Date FY: 2013 ( Subtotal = $2,150,500 )
2013	2013	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	8	9/6/2013	NON-COMPETING CONTINUATION	$2,150,500
														Subtotal = $2,150,500

Issue Date FY: 2012 ( Subtotal = $2,300,000 )
2012	2012	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	7	9/6/2012	NON-COMPETING CONTINUATION	$2,300,000
														Subtotal = $2,300,000

Issue Date FY: 2011 ( Subtotal = $2,185,000 )
2011	2011	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	002	6	9/23/2011	COMPETING CONTINUATION	$2,185,000
2011	2009	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	001	5	5/18/2011	SUPPLEMENT FOR EXPANSION	$0
2011	2008	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	5	5/18/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,185,000

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2009	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	000	5	11/3/2009	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $1,079,832 )
2009	2009	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Centers Support Grants	001	5	9/15/2009	SUPPLEMENT FOR EXPANSION	$1,079,832
2009	2008	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	5	11/24/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,079,832

Issue Date FY: 2008 ( Subtotal = $2,163,322 )
2008	2008	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	5	9/2/2008	NON-COMPETING CONTINUATION	$2,163,322
														Subtotal = $2,163,322

Issue Date FY: 2007 ( Subtotal = $2,163,323 ) (Continued on the next page)
Grand Total All Awards = $35,491,133

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City of Hope Lymphoma SPORE

Award Number: P50CA107399

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/02/2004

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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