Wednesday, January 15, 2025 1/15/2025

DF/HCC Kidney Cancer SPORE

Award Number: P50CA101942
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Summary This application represents a resubmission of a competing renewal application for a Specialized Program of Research Excellence (SPORE) in Kidney Cancer from the Kidney Cancer Program of Dana-Farber/Harvard Cancer Center (DF/HCC). The DF/HCC Kidney Cancer SPORE has been funded for two cycles since 2003. DF/HCC is comprised of the following institutions: Beth Israel-Deaconess Medical Center (BIDMC); Dana- Farber Cancer Institute (DFCI); Harvard Medical School; Harvard School of Public Health; Brigham and Women’s Hospital; Massachusetts General Hospital (MGH); and Children’s Hospital of Boston. In addition to the institutions in the DF/HCC, the Georgetown-Lombardi Cancer Center (GLCC) is collaborating institutions in this grant. The DF/HCC Kidney Cancer SPORE has its administrative base at the BIDMC. Dr. David McDermott, who has led the DF/HCC Kidney Cancer Program and SPORE since 2012 is joined as SPORE Director by Dr. William Kaelin, a laboratory scientist at DFCI and has served with Dr. McDermott as Director of the SPORE since early 2014. Dr. Kaelin is a world renowned basic and translational investigator with longstanding interest in renal cancer and a leader within the DF/HCC community. Drs. McDermott and Kaelin report directly to Dr. Laurie Glimcher, Director of DF/HCC and President of DFCI. The DF/HCC Kidney Cancer SPORE has a broad and deep talent base and there is extensive institutional commitment. We take advantage of a large patient population and cutting edge technologies that are available to us as part of DF/HCC. We propose 3 Projects which address critical problems in kidney cancer and have translational components. They focus on identifying effective strategies for targeting: HIF2α, the dominant oncogenic driver of clear-cell RCC (Project 1), resistance mechanisms of standard therapies (Projects 2-3, DRP 17), novel immune checkpoint pathways (Project 3) and rare kidney tumor types (e.g. NF2 mutated and translocation RCC, DRP 18 and 17). The projects are supported by three Cores - an Administrative Core, a Biostatistics and Computational Biology Core, and a Tissue Acquisition, Pathology and Clinical Data Core. We also have a highly successful Career Development Program that selects talented physician scientists and mentors them to independence as well as a Developmental Projects Program that generates new ideas for the SPORE in the future. The existence of the SPORE has provided opportunities and incentives to extend basic science and clinical research ideas into the translational realm and facilitated the entry of young, as well as some seasoned, investigators into the kidney cancer field where they have made major contributions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,219,550 )
2024	2024	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	002	20	7/31/2024	NON-COMPETING CONTINUATION	$2,219,550
2024	2023	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	001	19	2/6/2024	NON-COMPETING CONTINUATION	$0
2024	2023	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	19	12/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,219,550

Issue Date FY: 2023 ( Subtotal = $2,188,219 )
2023	2023	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	002	19	8/11/2023	NON-COMPETING CONTINUATION	$20
2023	2023	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	001	19	8/9/2023	NON-COMPETING CONTINUATION	$2,188,199
2023	2023	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	003	19	8/30/2023	NON-COMPETING CONTINUATION	$0
2023	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	18	4/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,188,219

Issue Date FY: 2022 ( Subtotal = $2,148,449 )
2022	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	003	18	9/14/2022	NON-COMPETING CONTINUATION	$2,100,743
2022	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	004	18	9/21/2022	NON-COMPETING CONTINUATION	$47,706
2022	2021	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	002	17	3/29/2022	NON-COMPETING CONTINUATION	$0
2022	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	001	16	10/15/2021	COMPETING CONTINUATION	$80,256
2022	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	15	10/15/2021	NON-COMPETING CONTINUATION	-$80,256
														Subtotal = $2,148,449

Issue Date FY: 2021 ( Subtotal = $2,272,484 )
2021	2021	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	007	17	9/1/2021	NON-COMPETING CONTINUATION	$2,272,484
2021	2021	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	008	17	9/17/2021	NON-COMPETING CONTINUATION	$0
2021	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	006	16	7/7/2021	COMPETING CONTINUATION	-$287,905
2021	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	004	16	7/2/2021	COMPETING CONTINUATION	$0
2021	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	003	16	5/3/2021	COMPETING CONTINUATION	$0
2021	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	002	16	3/9/2021	COMPETING CONTINUATION	$287,905
2021	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	16	12/2/2020	COMPETING CONTINUATION	$0
2021	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	005	15	7/7/2021	NON-COMPETING CONTINUATION	$287,905
2021	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	001	15	3/9/2021	NON-COMPETING CONTINUATION	-$287,905
														Subtotal = $2,272,484

Issue Date FY: 2020 ( Subtotal = $2,543,224 )
2020	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	001	16	6/30/2020	COMPETING CONTINUATION	$2,543,224
2020	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	15	3/27/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,543,224

Issue Date FY: 2019 ( Subtotal = $2,139,000 )
2019	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	15	8/28/2019	NON-COMPETING CONTINUATION	$2,139,000
														Subtotal = $2,139,000

Issue Date FY: 2018 ( Subtotal = $2,300,000 )
2018	2018	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	14	8/28/2018	NON-COMPETING CONTINUATION	$2,300,000
														Subtotal = $2,300,000

Issue Date FY: 2017 ( Subtotal = $2,300,000 )
2017	2017	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	001	13	9/21/2017	NON-COMPETING CONTINUATION	$115,001
2017	2017	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	13	8/24/2017	NON-COMPETING CONTINUATION	$2,184,999
														Subtotal = $2,300,000

Issue Date FY: 2016 ( Subtotal = $2,156,131 )
2016	2016	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	12	8/23/2016	NON-COMPETING CONTINUATION	$2,156,131
														Subtotal = $2,156,131

Issue Date FY: 2015 ( Subtotal = $2,185,000 )
2015	2015	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	002	11	9/17/2015	COMPETING CONTINUATION	$2,185,000
2015	2013	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	10	6/4/2015	NON-COMPETING CONTINUATION	$0
2015	2013	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	10	9/14/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,185,000

Issue Date FY: 2013 ( Subtotal = $2,150,502 )
2013	2013	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	10	6/12/2013	NON-COMPETING CONTINUATION	$2,070,000
2013	2013	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	001	10	7/31/2013	NON-COMPETING CONTINUATION	$80,502
														Subtotal = $2,150,502

Issue Date FY: 2012 ( Subtotal = $2,300,000 )
2012	2012	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	9	7/26/2012	NON-COMPETING CONTINUATION	$2,300,000
														Subtotal = $2,300,000

Issue Date FY: 2011 ( Subtotal = $2,185,000 )
2011	2011	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	8	8/19/2011	NON-COMPETING CONTINUATION	$2,185,000
														Subtotal = $2,185,000

Issue Date FY: 2010 ( Subtotal = $2,300,000 ) (Continued on the next page)
2010	2010	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	001	7	5/27/2010	NON-COMPETING CONTINUATION	$2,300,000
Grand Total All Awards = $46,989,719

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DF/HCC Kidney Cancer SPORE

Award Number: P50CA101942

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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