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SPORE in Multiple Myeloma

Award Number: P50CA100707
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2003
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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SPORE in Multiple Myeloma - OVERALL SUMMARY The Dana Farber/Harvard Cancer Center (DF/HCC) multiple myeloma (MM) SPORE renewal application consists of 3 Research Projects and 3 Cores, as well as the Career Enhancement and Developmental Research Programs. During the previous funding period, we have capitalized on the complementary strengths of the research, clinical expertise, and facilities of the Harvard affiliated institutions including Dana Farber Cancer Institute, Massachusetts General Hospital, Harvard Medical School, and Harvard School of Public Health. We have successfully translated multiple novel agents from the bench to the bedside and FDA approval for treatment of MM. In this SPORE renewal application one new project has evolved from prior Developmental Projects, and three investigators who are now Co-PI's have previously received Developmental Research or Career Enhancement Awards. This new project focuses on developing novel therapeutic strategies in Waldenstrom's macroglobulinemia, a plasma cell disorder with unique biology. The group as a whole has a long-term commitment to translational MM research, with the necessary administrative, basic science, and clinical infrastructure. At our well established centers, more than 750 new patients with MM are evaluated annually, as well as 10,000 outpatient visits for established patients with plasma cell dyscrasias. The spectrum of diseases evaluated spans from monoclonal gammopathy of unclear significance to plasma cell leukemia to Waldenstrom's macroglobulinemia. Our center has appropriate scientific and institutional review boards, as well as protocol audit and quality control centers, to conduct cutting-edge translational research. This large combined patient base assures rapid accrual and evaluation of the therapeutic efficacy of novel agents identified in this program with over 40 active protocols. Success of both the preclinical and clinical components of this Program is dependent upon synergy and communication between these investigators which is assured by the access to all the Principal Investigators to the preclinical data generated in joint research efforts. Currently there is systematic quality-controlled exchange of bone marrow and blood samples for correlative basic laboratory studies. The overall goal of this DF/HCC myeloma SPORE is to take advantage of our increased understanding of the genetic and molecular basis of multiple myeloma and Waldenstrom's macroglobulinemia to develop novel, effective therapeutic strategies for patients. The translational nature of the SPORE is highlighted by the fact that most of our projects have emanated from clinical studies from the outset. Specific Projects are: (1) Therapeutically Targeting Ubiquitin Receptors in Multiple Myeloma; (2) Targeting AP Nuclease, a Mediator of Genomic Instability in MM; (3) Targeting Mutated MYD88 Signaling in WM; An Administration Communication and Planning Core; as well as Tissue Core 1 and Biostatistics and Bioinformatics Core 2, will continue to support the program. This Program therefore helps move rational novel targeted therapies from the laboratory to clinical protocols to improve patient outcome in MM.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$552,410 )
2025	2023	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	001	20	11/19/2024	NON-COMPETING CONTINUATION	$0
2025	2023	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Centers Support Grants	000	20	10/11/2024	NON-COMPETING CONTINUATION	-$552,410
														Subtotal = -$552,410

Issue Date FY: 2023 ( Subtotal = $2,257,199 )
2023	2023	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	20	7/6/2023	NON-COMPETING CONTINUATION	$2,257,199
2023	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	19	1/10/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,257,199

Issue Date FY: 2022 ( Subtotal = $2,257,199 )
2022	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	19	6/23/2022	NON-COMPETING CONTINUATION	$2,208,656
2022	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	19	9/21/2022	NON-COMPETING CONTINUATION	$48,543
														Subtotal = $2,257,199

Issue Date FY: 2021 ( Subtotal = $2,257,199 )
2021	2021	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	18	7/9/2021	NON-COMPETING CONTINUATION	$2,257,199
2021	2020	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	17	3/11/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,257,199

Issue Date FY: 2020 ( Subtotal = $2,349,611 )
2020	2020	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	17	6/16/2020	NON-COMPETING CONTINUATION	$2,305,740
2020	2020	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	002	17	9/14/2020	NON-COMPETING CONTINUATION	$43,871
2020	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	15	1/31/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,349,611

Issue Date FY: 2019 ( Subtotal = $2,276,698 )
2019	2019	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	16	8/12/2019	COMPETING CONTINUATION	$2,276,698
2019	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	15	8/7/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,276,698

Issue Date FY: 2017 ( Subtotal = $2,300,000 )
2017	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	15	8/31/2017	NON-COMPETING CONTINUATION	$2,185,001
2017	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	002	15	9/20/2017	NON-COMPETING CONTINUATION	$114,999
2017	2015	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	13	2/13/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,300,000

Issue Date FY: 2016 ( Subtotal = $2,162,000 )
2016	2016	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	14	8/3/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,162,000
														Subtotal = $2,162,000

Issue Date FY: 2015 ( Subtotal = $2,185,000 )
2015	2015	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	13	8/7/2015	NON-COMPETING CONTINUATION	$2,185,000
														Subtotal = $2,185,000

Issue Date FY: 2014 ( Subtotal = $2,162,001 )
2014	2014	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	12	9/17/2014	NON-COMPETING CONTINUATION	$2,162,001
														Subtotal = $2,162,001

Issue Date FY: 2013 ( Subtotal = $2,150,500 )
2013	2013	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	11	9/18/2013	COMPETING CONTINUATION	$2,150,500
2013	2012	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	10	9/18/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,150,500

Issue Date FY: 2012 ( Subtotal = $2,300,000 )
2012	2012	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	10	8/29/2012	NON-COMPETING CONTINUATION	$2,300,000
														Subtotal = $2,300,000

Issue Date FY: 2011 ( Subtotal = $2,185,000 )
2011	2011	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	9	8/17/2011	NON-COMPETING CONTINUATION	$2,185,000
														Subtotal = $2,185,000

Issue Date FY: 2010 ( Subtotal = $2,300,000 )
2010	2010	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	001	8	8/30/2010	NON-COMPETING CONTINUATION	$2,300,000
2010	2009	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	7	11/3/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,300,000

Issue Date FY: 2009 ( Subtotal = $2,472,667 )
2009	2009	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Recovery Act Research Support	001	7	8/31/2009	SUPPLEMENT FOR EXPANSION	$172,667
2009	2009	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	7	8/14/2009	NON-COMPETING CONTINUATION	$2,300,000
														Subtotal = $2,472,667

Issue Date FY: 2008 ( Subtotal = $2,300,000 )
2008	2008	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	6	8/7/2008	COMPETING CONTINUATION	$2,300,000
														Subtotal = $2,300,000

Issue Date FY: 2007 ( Subtotal = $2,136,145 )
2007	2007	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	5	7/26/2007	NON-COMPETING CONTINUATION	$2,136,145
														Subtotal = $2,136,145

Issue Date FY: 2006 ( Subtotal = $2,199,943 )
2006	2006	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	4	8/21/2006	NON-COMPETING CONTINUATION	$2,199,943
														Subtotal = $2,199,943

Issue Date FY: 2005 ( Subtotal = $2,252,886 )
2005	2005	DANA-FARBER CANCER INSTITUTE	44 BINNEY STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Centers Support Grants	000	3	9/13/2005	NON-COMPETING CONTINUATION	$2,252,886
														Subtotal = $2,252,886

Grand Total All Awards = $44,449,756

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SPORE in Multiple Myeloma

Award Number: P50CA100707

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2003

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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