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SPORE in Breast Cancer

Award Number: P50CA058223
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/05/1997
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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SPORE in Breast Cancer - This is the competitive renewal for year 30-34 of the UNC Breast Cancer SPORE. SPORE goals and aims have been reinvigorated every five years with advice from a robust advocate group and an insightful series of external and internal advisors. However, the emphasis on environment and demographics including rurality, genomics, and other risk factors in breast cancer disparities has been consistent. Genomic technology and analytic capacity, subtyping/biomarker research and therapeutic resistance have also been consistent, as has the recruitment and mentoring of junior faculty. Career development has returned dividends, with multiple SPORE leaders being previous recipients of CEP funds. One constant since 1992 is a biospecimen, epidemiologic, and clinical data-rich population-based Carolina Breast Cancer Study (CBCS). CBCS Phase 3 (3,000 new cases, 2008-2013) has collected ten years of follow-up; CBCS 4 will recruit an additional 3,000 new cases, again with oversampling of younger (50% of the study population) women, who are typically understudied in genomic and health services research. CBCS has made seminal contributions to our understanding of Triple Negative Breast Cancer (TNBC) and other subtypes in multiple populations with 230+ papers published (47 from this cycle), many high impact and heavily cited. CBCS will focus on a cells-to-society model wherein tumor biology and immune response are part of a complex system that includes differences in health care access and environments. All 4 projects, which share a focus on TNBC that disproportionately afflicts young women, will contribute to understanding across this spectrum. Continued institutional investment, averaging $2-$2.5M yearly, allows the renewed SPORE to: i) Incorporate new technologies and methods; ii) Develop infrastructure for population and translational research; and iii) Support junior and mid-level faculty from the population, basic, and clinical sciences. In the past 5 years the CEP has supported 17 new faculty who successfully competed for foundation, cooperative group, and NCI funding. DRP funded multiple collaborative projects (two are among the 4 Projects in this application). With EAB, Advocate, and Executive Committee input, the MPIs Perou and Carey selected four Projects, focusing on determinants of health, biomarkers, immune-based therapeutics and TNBC therapeutic resistance: Project #1 – Carolina Breast Cancer Study (CBCS): Linking Tumor Biology and Demographics to Outcomes (Troester PhD, and Reeder-Hayes MD, MBA MSc), Project #2 – Determinants of Response and Resistance to DNA-Damaging Radiation Plus Immunotherapy Combinations in TNBC (Gupta MD, PhD, and Vincent MD), Project #3 – Development of Novel Therapies and Biomarkers for TNBC (Perou PhD, and Carey MD, ScM), Project #4 – Activity of CAR-T Cell Therapy for Patients with Metastatic TNBC (Dotti PhD, Serody MD, and Abdou MD).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,347,817 )
2026	2026	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	31	8/5/2026	NON-COMPETING CONTINUATION	$2,347,817
														Subtotal = $2,347,817

Issue Date FY: 2025 ( Subtotal = $2,348,589 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	30	9/8/2025	NON-COMPETING CONTINUATION	$2,348,589
2025	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	28	3/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,348,589

Issue Date FY: 2024 ( Subtotal = $2,268,690 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	29	9/3/2024	COMPETING CONTINUATION	$2,268,690
														Subtotal = $2,268,690

Issue Date FY: 2022 ( Subtotal = $2,324,485 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	28	8/16/2022	NON-COMPETING CONTINUATION	$2,274,486
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	28	9/21/2022	NON-COMPETING CONTINUATION	$49,999
														Subtotal = $2,324,485

Issue Date FY: 2021 ( Subtotal = $2,323,936 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	000	27	8/12/2021	NON-COMPETING CONTINUATION	$2,323,936
														Subtotal = $2,323,936

Issue Date FY: 2020 ( Subtotal = $2,293,534 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	001	26	8/21/2020	NON-COMPETING CONTINUATION	$2,293,534
2020	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	000	25	8/13/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,293,534

Issue Date FY: 2019 ( Subtotal = $2,323,522 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	002	25	9/6/2019	NON-COMPETING CONTINUATION	$2,323,522
2019	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	001	24	1/14/2019	COMPETING CONTINUATION	$1,415
2019	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	23	1/14/2019	EXTENSION WITH OR WITHOUT FUNDS	-$1,415
														Subtotal = $2,323,522

Issue Date FY: 2018 ( Subtotal = $2,499,932 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	000	24	8/22/2018	COMPETING CONTINUATION	$2,499,932
														Subtotal = $2,499,932

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	23	5/16/2017	EXTENSION WITH OR WITHOUT FUNDS	$92,661
2017	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	002	23	9/20/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
2017	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	22	5/16/2017	SUPPLEMENT FOR EXPANSION	-$92,661
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $1,725,265 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	23	8/10/2016	EXTENSION WITH OR WITHOUT FUNDS	$1,725,265
														Subtotal = $1,725,265

Issue Date FY: 2015 ( Subtotal = $1,922,464 )
2015	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	22	8/18/2015	SUPPLEMENT FOR EXPANSION	$97,292
2015	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	22	8/18/2015	NON-COMPETING CONTINUATION	$1,825,172
														Subtotal = $1,922,464

Issue Date FY: 2014 ( Subtotal = $1,914,286 )
2014	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	21	9/16/2014	SUPPLEMENT FOR EXPANSION	$97,292
2014	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	21	9/2/2014	NON-COMPETING CONTINUATION	$1,816,994
														Subtotal = $1,914,286

Issue Date FY: 2013 ( Subtotal = $1,691,744 )
2013	2013	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	20	8/20/2013	NON-COMPETING CONTINUATION	$1,691,744
														Subtotal = $1,691,744

Issue Date FY: 2012 ( Subtotal = $1,933,963 )
2012	2012	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	19	9/14/2012	COMPETING CONTINUATION	$1,933,963
														Subtotal = $1,933,963

Issue Date FY: 2010 ( Subtotal = $2,119,685 )
2010	2010	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	18	8/26/2010	NON-COMPETING CONTINUATION	$2,119,685
														Subtotal = $2,119,685

Issue Date FY: 2009 ( Subtotal = $3,576,684 )
2009	2009	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	17	7/30/2009	NON-COMPETING CONTINUATION	$2,119,686
2009	2009	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Recovery Act Research Support	002	17	8/31/2009	SUPPLEMENT FOR EXPANSION	$1,456,998
2009	2008	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	16	11/10/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,576,684

Issue Date FY: 2008 ( Subtotal = $2,116,400 )
2008	2008	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	16	7/23/2008	NON-COMPETING CONTINUATION	$2,116,400
														Subtotal = $2,116,400

Issue Date FY: 2007 ( Subtotal = $2,065,692 )
2007	2007	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	15	9/19/2007	NON-COMPETING CONTINUATION	$2,065,692
														Subtotal = $2,065,692

Issue Date FY: 2006 ( Subtotal = $2,666,728 ) (Continued on the next page)
2006	2006	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	14	9/27/2006	COMPETING CONTINUATION	$2,182,992
2006	2006	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	002	14	9/29/2006	SUPPLEMENT FOR EXPANSION	$225,000
Grand Total All Awards = $60,965,385

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SPORE in Breast Cancer

Award Number: P50CA058223

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/05/1997

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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