Sunday, August 17, 2025 8/17/2025

Dissecting Functional Autoimmunity through High-Resolution Multiomics in a Vitiligo Center of Research Translation (V-CoRT)

Award Number: P50AR080593
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/12/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

Group Awards By:

View Award Description

Dissecting Functional Autoimmunity through High-Resolution Multiomics in a Vitiligo Center of Research Translation (V-CoRT) - OVERALL – PROJECT SUMMARY Organ-specific autoimmunity requires a series of precise cellular interactions to coordinate target cell destruc- tion within complex tissues. Vitiligo is an autoimmune disease of the skin in which cytotoxic CD8+ T cells target pigment-making melanocytes, which results in disfiguring white spots that are particularly devastating for those with darker skin. Vitiligo is an ideal disease in which to investigate mechanisms of organ-specific autoimmunity because disease phenotype can be directly correlated to molecular pathways. That is, affected skin can be ob- served and sampled, target cells and antigens are known, and translational research tools are available. Viti- ligo shares genetic risk alleles and other mechanisms with autoimmune diseases like type 1 diabetes and mul- tiple sclerosis, which are more difficult to study in human patients. Through vitiligo we can develop a compre- hensive understanding of organ-specific autoimmunity as it progresses within human tissue. Our objective is to determine the mechanisms by which autoreactive T cells navigate the skin, communicate with neighboring cells, engage and destroy melanocytes, and create long-term memory of autoimmunity di- rectly within vitiligo lesions. We generated an extensive set of high-resolution, translational multiomics data from vitiligo patient skin and assembled it into an integrated communication network among multiple cell types that coordinate disease progression. This provides clues into vitiligo pathogenesis that must now be validated, dissected, and reassembled to reveal fundamental concepts of autoimmunity. Thus, we hypothesize that auto- reactive T cell function is carefully coordinated by cellular signals within the microenvironment of the epidermis. To test this hypothesis, we will leverage existing data, a multidisciplinary team of leading investigators, cutting edge tools designed for discovery, and an innovative strategy to discover how skin cells coordinate autoim- munity during vitiligo. Project 1 will investigate Autoreactive T cell Function in Vitiligo to determine how autore- active T cell clonal diversity and localization define the clinical disease phenotype and coordinate melanocyte destruction. Project 2 will focus on Cell-Cell Communications and Tissue Memory in Vitiligo to dissect the mechanisms by which ligand-receptor interactions coordinate T cell localization, function, and inflammatory memory. These projects will be supported by the High-Resolution Spatial Transcriptomics Research Core us- ing seq-FISH+ to translate our vitiligo multiomics data into a complete spatial understanding of cellular position and communication within vitiligo lesions. The Administrative Core will promote communication, ensure scien- tific achievement, and monitor fiscal management to support focus on research goals and implementation. We expect to create an integrated understanding of coordinated cellular communications and interactions that drive vitiligo pathogenesis. This will reveal fundamental mechanisms of autoimmunity and support better thera- peutic approaches for these devastating diseases. The unique characteristics of vitiligo as well as our prelimi- nary data, investigative team, and innovative plan provide us with an unparalleled opportunity for discovery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,495,911 )
2025	2025	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	4	7/15/2025	NON-COMPETING CONTINUATION	$1,495,911
2025	2025	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	4	8/7/2025	NON-COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	2/13/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,495,911

Issue Date FY: 2024 ( Subtotal = $1,662,123 )
2024	2024	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	3	8/14/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	7/31/2024	NON-COMPETING CONTINUATION	$1,662,123
														Subtotal = $1,662,123

Issue Date FY: 2023 ( Subtotal = $1,662,123 )
2023	2023	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	6/15/2023	NON-COMPETING CONTINUATION	$1,662,123
														Subtotal = $1,662,123

Issue Date FY: 2022 ( Subtotal = $1,678,998 )
2022	2022	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE NORTH	WORCESTER	MA	01655	WORCESTER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/12/2022	NEW	$1,678,998
														Subtotal = $1,678,998

Grand Total All Awards = $6,499,155

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Dissecting Functional Autoimmunity through High-Resolution Multiomics in a Vitiligo Center of Research Translation (V-CoRT)

Award Number: P50AR080593

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/12/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer