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Host and Parasite Determinants in Human Leishmaniasis

Award Number: P50AI030639
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/1991
PERIOD OF PERFORMANCE END DATE: 09/30/2023

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Host and Parasite Determinants in Human Leishmaniasis - Leishmaniasis affects 12 million people worldwide, with an estimated 2 million new infection occurring annually. All four main forms of disease, visceral (VL), cutaneous (CL), disseminated (DL) and mucosal leishmaniasis (ML), are prevalent in our study areas in the Northeast of Brazil. The main objective of this program is to expand and translate the knowledge acquired in the host parasite relationship in leishmaniasis to improve diagnose, establish new forms of therapy and to control leishmaniasis. The Federal University of Bahia (UFBA) Tropical Medicine Research Center was established in 1991. The Federal University of Rio Grande do Norte joined the TMRC in 1996 to share their expertise in VL. Strong collaborative programs have been established between Brazilian and US universities in Tropical diseases. This proposal entitled "Host and Parasite Determinants in Human Leishmaniasis" has 4 cores (administrative, data management, epidemiology and transcriptomics) and 3 scientific projects. Project I "Polymorphic features of Leishmania braziliensis: disease manifestations, geographic distribution, and genomes" will be use molecular and epidemiological tools to improve diagnosis associating genotype of parasite with clinical forms of leishmaniasis, as well as to identify isolates resistant to antimony therapy. Project II "Protective and pathological immune response In L. braziliensis infection" will address the role of innate Immunity in control L. braziliensis infection in individuals with subclinical L. braziliensis infection as well as the role of CD8+T cells and macrophages in the pathology of American Tegumentary Leishmaniasis. Project III "Genetic and Environmental Determinants of Symptomatic and Asymptomatic Leishmaniasis" will determine host genetic determinants affecting the outcome of visceral and tegumentary leishmaniasis, will perform transcriptome profiling of blood of VL patients in order to identify potential markers of progression or control f leishmania infection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $124,332 )
2023	2023	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO	RUA PROFESSOR EDGARD MATA 001	SALVADOR				BRA	Allergy and Infectious Diseases Research	001	24	9/7/2023	SUPPLEMENT FOR EXPANSION	$124,332
2023	2016	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO	RUA PROFESSOR EDGARD MATA 001	SALVADOR				BRA	Allergy and Infectious Diseases Research	000	24	9/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $124,332

Issue Date FY: 2020 ( Subtotal = $54,350 )
2020	2016	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO - FAPEX.	RUA CAETANO MOURA 140	SALVADOR	BA	40210-340		BRA	Allergy and Infectious Diseases Research	000	24	8/12/2020	NON-COMPETING CONTINUATION	$54,350
														Subtotal = $54,350

Issue Date FY: 2018 ( Subtotal = -$178,682 )
2018	2016	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO - FAPEX.	RUA CAETANO MOURA 140	SALVADOR	BA	40210-340		BRA	Allergy and Infectious Diseases Research	000	24	1/4/2018	NON-COMPETING CONTINUATION	-$178,682
														Subtotal = -$178,682

Issue Date FY: 2016 ( Subtotal = $299,958 )
2016	2016	FUNDACAO DE APOIO A PESQUIS E A EXTENSAO DBA FAPEX	RUA CAETANO MOURA 140	SALVADOR				BRA	Allergy and Infectious Diseases Research	000	24	7/22/2016	NON-COMPETING CONTINUATION	$299,958
														Subtotal = $299,958

Issue Date FY: 2015 ( Subtotal = $299,958 )
2015	2015	FUNDACAO DE APOIO A PESQUIS E A EXTENSAO DBA FAPEX	RUA CAETANO MOURA 140	SALVADOR				BRA	Allergy and Infectious Diseases Research	000	23	7/15/2015	NON-COMPETING CONTINUATION	$299,958
														Subtotal = $299,958

Issue Date FY: 2014 ( Subtotal = $299,958 )
2014	2014	FUNDACAO DE APOIO A PESQUIS E A EXTENSAO DBA FAPEX	RUA CAETANO MOURA 140	SALVADOR				BRA	Allergy and Infectious Diseases Research	000	22	7/16/2014	NON-COMPETING CONTINUATION	$299,958
														Subtotal = $299,958

Issue Date FY: 2013 ( Subtotal = $281,961 )
2013	2013	FUNDACAO DE APOIO A PESQUIS E A EXTENSAO DBA FAPEX	RUA CAETANO MOURA 140	SALVADOR				BRA	Allergy and Infectious Diseases Research	001	21	8/21/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$281,961
2013	2012	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Allergy and Infectious Diseases Research	000	20	8/20/2013	COMPETING CONTINUATION	$0
														Subtotal = $281,961

Issue Date FY: 2012 ( Subtotal = $299,958 )
2012	2012	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Allergy and Infectious Diseases Research	002	20	8/22/2012	COMPETING CONTINUATION	$0
2012	2012	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Allergy and Infectious Diseases Research	001	20	7/5/2012	COMPETING CONTINUATION	$0
2012	2012	UNIVERSITY OF BAHIA	HUPES-SERVICO DE IMUNOLOGIA RUA JOA	SALVADOR				BRA	Allergy and Infectious Diseases Research	000	20	6/29/2012	COMPETING CONTINUATION	$299,958
														Subtotal = $299,958

Issue Date FY: 2011 ( Subtotal = $671,137 )
2011	2011	UNIVERSITY OF BAHIA	HUPES-SERVICO DE IMUNOLOGIA RUA JOA	SALVADOR				BRA	Allergy and Infectious Diseases Research	000	19	7/6/2011	NON-COMPETING CONTINUATION	$671,137
														Subtotal = $671,137

Issue Date FY: 2010 ( Subtotal = $678,809 )
2010	2010	UNIVERSITY OF BAHIA	HUPES-SERVICO DE IMUNOLOGIA RUA JOA	SALVADOR				BRA	Allergy and Infectious Diseases Research	000	18	7/15/2010	NON-COMPETING CONTINUATION	$678,809
														Subtotal = $678,809

Issue Date FY: 2009 ( Subtotal = $688,682 )
2009	2009	UNIVERSITY OF BAHIA	HUPES-SERVICO DE IMUNOLOGIA RUA JOA	SALVADOR				BRA	Allergy and Infectious Diseases Research	000	17	7/8/2009	NON-COMPETING CONTINUATION	$688,682
														Subtotal = $688,682

Issue Date FY: 2008 ( Subtotal = $711,395 )
2008	2008	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Allergy and Infectious Diseases Research	000	16	6/30/2008	COMPETING CONTINUATION	$711,395
														Subtotal = $711,395

Issue Date FY: 2007 ( Subtotal = $660,429 )
2007	2007	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Allergy and Infectious Diseases Research	001	15	9/25/2007	SUPPLEMENT FOR EXPANSION	$660,429
														Subtotal = $660,429

Issue Date FY: 2006 ( Subtotal = $684,468 )
2006	2006	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Allergy and Infectious Diseases Research	000	15	7/13/2006	NON-COMPETING CONTINUATION	$684,468
														Subtotal = $684,468

Issue Date FY: 2005 ( Subtotal = $671,245 )
2005	2005	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Microbiology and Infectious Diseases Research	000	14	8/8/2005	NON-COMPETING CONTINUATION	$671,245
														Subtotal = $671,245

Issue Date FY: 2004 ( Subtotal = $651,695 )
2004	2004	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Microbiology and Infectious Diseases Research	000	13	8/23/2004	NON-COMPETING CONTINUATION	$651,695
														Subtotal = $651,695

Issue Date FY: 2003 ( Subtotal = $641,714 )
2003	2003	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Microbiology and Infectious Diseases Research	000	12	6/30/2003	NON-COMPETING CONTINUATION	$641,714
														Subtotal = $641,714

Issue Date FY: 2002 ( Subtotal = $590,183 )
2002	2002	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Microbiology and Infectious Diseases Research	000	11	9/20/2002	COMPETING CONTINUATION	$590,183
														Subtotal = $590,183

Issue Date FY: 2001 ( Subtotal = $313,371 )
2001	2001	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Microbiology and Infectious Diseases Research	001	10	7/13/2001	SUPPLEMENT FOR EXPANSION	$313,371
														Subtotal = $313,371

Issue Date FY: 2000 ( Subtotal = $555,994 )
2000	2000	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Microbiology and Infectious Diseases Research	000	10	7/28/2000	NON-COMPETING CONTINUATION	$555,994
														Subtotal = $555,994

Issue Date FY: 1999 ( Subtotal = $593,486 )
1999	1999	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Microbiology and Infectious Diseases Research	000	9	8/27/1999	NON-COMPETING CONTINUATION	$593,486
														Subtotal = $593,486

Issue Date FY: 1998 ( Subtotal = $573,890 )
1998	1998	UNIVERSITY OF BAHIA	**	SALVADOR, BAHIA		00000		BRA	Microbiology and Infectious Diseases Research	000	8	7/10/1998	NON-COMPETING CONTINUATION	$573,890
														Subtotal = $573,890

Grand Total All Awards = $10,168,291

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Host and Parasite Determinants in Human Leishmaniasis

Award Number: P50AI030639

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/1991

PERIOD OF PERFORMANCE END DATE: 09/30/2023

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