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The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury

Award Number: P50AA024337
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2016
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury - The University of Louisville Alcohol Research Center (ULARC) was created to serve as a regional/national resource to perform interdisciplinary collaborative research on the role of nutrition as a cofactor in alcohol induced organ injury and as a possible therapeutic intervention to prevent/treat this organ injury. The nutrition and alcohol-induced organ injury theme of the center is unique among alcohol centers. The approach is highly translational. Our investigators include faculty from 13 departments and 6 colleges. The Specific Aims of the ULARC are to: 1) perform/facilitate interdisciplinary research on nutrition and alcohol-induced organ injury; 2) serve as a regional/national resource for the study of nutrition and alcohol-induced organ injury; 3) develop potential therapeutic targets/interventions for alcohol induced organ injury based on the mechanistic research of the ULARC; and 4) disseminate knowledge/interventions to the scientific and lay communities. We will explore interactions of nutrition and alcohol abuse in the development of alcohol-induced organ dysfunction, and we will evaluate diverse potential nutritional preventive/therapeutic interventions. Project 1 (Kirpich/McClain) evaluates the role of dietary fat in ALD pathogenesis; Project 2 (Barve) evaluates alcohol- induced epigenetic alterations in the gut:liver axis. Project 3 (Chen) will elucidate the mechanisms by which enhancers mediate ethanol-induced developmental impairment of neural crest cells and teratogenesis and unique exosome treatment for prevention of FASD. Project 4 (Feng) studies the beneficial effects of the probiotic, Lactobacillus rhamnosis GG (LGG)on the gut:liver axis in ALD. Together, these projects form a cohesive and interactive approach to investigate the effects of nutrition and nutritional interventions on alcohol-induced organ injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,327,766 )
2025	2025	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	000	10	7/9/2025	NON-COMPETING CONTINUATION	$1,327,766
														Subtotal = $1,327,766

Issue Date FY: 2024 ( Subtotal = $1,357,495 )
2024	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	001	9	5/10/2024	NON-COMPETING CONTINUATION	$1,357,495
2024	2023	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	000	8	3/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,357,495

Issue Date FY: 2023 ( Subtotal = $1,386,365 )
2023	2023	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	000	8	4/27/2023	NON-COMPETING CONTINUATION	$1,386,365
														Subtotal = $1,386,365

Issue Date FY: 2022 ( Subtotal = $1,467,472 )
2022	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	002	7	5/21/2022	NON-COMPETING CONTINUATION	$1,467,472
2022	2021	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	001	6	10/20/2021	COMPETING CONTINUATION	$491,458
2022	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	000	5	10/20/2021	NON-COMPETING CONTINUATION	-$491,458
														Subtotal = $1,467,472

Issue Date FY: 2021 ( Subtotal = $1,436,994 )
2021	2021	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	000	6	6/8/2021	COMPETING CONTINUATION	$1,436,994
														Subtotal = $1,436,994

Issue Date FY: 2020 ( Subtotal = $1,532,474 )
2020	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	000	5	5/29/2020	NON-COMPETING CONTINUATION	$1,532,474
														Subtotal = $1,532,474

Issue Date FY: 2019 ( Subtotal = $1,532,474 )
2019	2019	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	000	4	4/17/2019	NON-COMPETING CONTINUATION	$1,532,474
														Subtotal = $1,532,474

Issue Date FY: 2018 ( Subtotal = $1,532,474 )
2018	2018	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	000	3	5/25/2018	NON-COMPETING CONTINUATION	$1,532,474
														Subtotal = $1,532,474

Issue Date FY: 2017 ( Subtotal = $1,532,475 )
2017	2017	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	001	2	7/27/2017	NON-COMPETING CONTINUATION	$153,246
2017	2017	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Alcohol Research Programs	000	2	5/1/2017	NON-COMPETING CONTINUATION	$1,379,229
														Subtotal = $1,532,475

Issue Date FY: 2016 ( Subtotal = $1,532,506 )
2016	2016	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Alcohol Research Programs	000	1	5/13/2016	NEW	$1,532,506
														Subtotal = $1,532,506

Grand Total All Awards = $14,638,495

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The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury

Award Number: P50AA024337

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2016

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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