Friday, March 14, 2025 3/14/2025

Alcohol Research Center - Treatment and Implications

Award Number: P50AA010761
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY The Charleston Alcohol Research Center (ARC) continues to focus on treatment and treatment implications as an overarching theme. The ARC maintains its long-standing tradition of embracing multidisciplinary and translational research approaches, integrating both basic research and clinical investigations all centered on this common theme. The ARC also continues its tradition of teaming junior faculty with more experienced investigators, capitalizing on new talent and bringing sophisticated cutting-edge technologies and research approaches that enhance research efforts in addressing the Center’s overall scientific goals. The ARC is comprised of five research projects and three cores. The Administrative Core provides the leadership and infrastructure to facilitate the overall scientific and educational mission of the Center as a whole. The Shared Resource Core provides vital scientific services needed by Center researchers to facilitate integration, maximize resources, and increase productivity. The Pilot Core attracts new investigators and new ideas to the Center, thereby broadening and augmenting its research and training activities. In this renewal application, proposed preclinical and clinical research projects all center on a common research focus – neuroadaptations in cortical processes that underlie transition to excessive drinking. Three basic research projects will use sophisticated circuitry mapping, cellular/molecular biology techniques, and behavioral procedures to examine how chronic alcohol exposure alters functional activity of cortical sub-regions and their projections, and how such adaptations in cortical-subcortical neurocircuitry mediate excessive drinking, which may be characterized as inflexible, compulsive/habit-like drinking. Two clinical research projects will employ sophisticated neuroimaging techniques to focus on similar cortical areas and projections in evaluating the ability of different treatment modalities (pharmacological and non-pharmacological) to alter the circuitry and reduce alcohol cue-induced brain activation, craving, and drinking. The Charleston ARC is poised to continue its national leadership role and demonstrated success in: (a) fostering multidisciplinary and translational state-of-the-art research efforts that are thematically-focused on the topic of treatment and treatment implications; (b) attracting new (especially early-stage) investigators into the Center, thereby invigorating its research efforts; and (c) providing a stimulating environment that enriches training opportunities and professional development for the next generation of researchers in the alcohol field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,556,932 )
2025	2025	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	30	1/17/2025	NON-COMPETING CONTINUATION	$1,556,932
														Subtotal = $1,556,932

Issue Date FY: 2024 ( Subtotal = $1,554,978 )
2024	2024	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	29	2/26/2024	NON-COMPETING CONTINUATION	$1,554,978
														Subtotal = $1,554,978

Issue Date FY: 2023 ( Subtotal = $1,918,835 )
2023	2023	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	28	1/30/2023	NON-COMPETING CONTINUATION	$1,554,892
2023	2023	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	001	28	5/9/2023	SUPPLEMENT FOR EXPANSION	$363,943
														Subtotal = $1,918,835

Issue Date FY: 2022 ( Subtotal = $1,552,591 )
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	001	27	1/12/2022	NON-COMPETING CONTINUATION	$1,397,332
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	002	27	6/23/2022	NON-COMPETING CONTINUATION	$155,259
2022	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	26	11/11/2021	COMPETING CONTINUATION	$0
														Subtotal = $1,552,591

Issue Date FY: 2021 ( Subtotal = $1,549,267 )
2021	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	002	26	5/20/2021	COMPETING CONTINUATION	$1,055,183
2021	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	26	1/15/2021	COMPETING CONTINUATION	$1,549,267
2021	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	001	25	5/17/2021	NON-COMPETING CONTINUATION	-$1,055,183
														Subtotal = $1,549,267

Issue Date FY: 2020 ( Subtotal = $1,392,848 )
2020	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	25	12/20/2019	NON-COMPETING CONTINUATION	$1,392,848
														Subtotal = $1,392,848

Issue Date FY: 2019 ( Subtotal = $1,392,852 )
2019	2019	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	24	12/31/2018	NON-COMPETING CONTINUATION	$1,392,852
														Subtotal = $1,392,852

Issue Date FY: 2018 ( Subtotal = $1,409,938 )
2018	2018	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	001	23	5/25/2018	NON-COMPETING CONTINUATION	$140,994
2018	2018	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	23	12/28/2017	NON-COMPETING CONTINUATION	$1,268,944
														Subtotal = $1,409,938

Issue Date FY: 2017 ( Subtotal = $1,409,941 )
2017	2017	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	22	12/21/2016	NON-COMPETING CONTINUATION	$1,268,947
2017	2017	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	001	22	7/19/2017	NON-COMPETING CONTINUATION	$140,994
														Subtotal = $1,409,941

Issue Date FY: 2016 ( Subtotal = $1,460,395 )
2016	2016	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	001	21	7/12/2016	SUPPLEMENT FOR EXPANSION	$99,996
2016	2016	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	000	21	12/25/2015	COMPETING CONTINUATION	$1,360,399
2016	2016	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 Ashley Ave	CHARLESTON	SC	294258908	CHARLESTON	USA	Alcohol Research Programs	002	21	7/15/2016	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,460,395

Issue Date FY: 2015 ( Subtotal = $1,686,252 )
2015	2015	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	000	20	12/30/2014	NON-COMPETING CONTINUATION	$1,564,566
2015	2015	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	001	20	1/27/2015	NON-COMPETING CONTINUATION	$121,686
														Subtotal = $1,686,252

Issue Date FY: 2014 ( Subtotal = $1,795,742 )
2014	2014	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	002	19	7/2/2014	SUPPLEMENT FOR EXPANSION	$147,923
2014	2014	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	001	19	4/8/2014	NON-COMPETING CONTINUATION	$118,915
2014	2014	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	000	19	1/30/2014	NON-COMPETING CONTINUATION	$1,528,904
														Subtotal = $1,795,742

Issue Date FY: 2013 ( Subtotal = $1,610,516 )
2013	2013	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	000	18	12/27/2012	NON-COMPETING CONTINUATION	$1,558,566
2013	2013	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	001	18	6/5/2013	NON-COMPETING CONTINUATION	$51,950
														Subtotal = $1,610,516

Issue Date FY: 2012 ( Subtotal = $1,765,547 )
2012	2012	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	000	17	12/30/2011	NON-COMPETING CONTINUATION	$1,620,001
2012	2012	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	001	17	2/27/2012	NON-COMPETING CONTINUATION	$145,546
														Subtotal = $1,765,547

Issue Date FY: 2011 ( Subtotal = $1,799,999 )
2011	2011	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	001	16	8/31/2011	COMPETING CONTINUATION	$89,787
2011	2011	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Programs	000	16	2/21/2011	COMPETING CONTINUATION	$1,710,212
														Subtotal = $1,799,999

Issue Date FY: 2010 ( Subtotal = $1,866,999 )
2010	2010	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Center Grants	002	15	1/15/2010	NON-COMPETING CONTINUATION	$1,695,716
2010	2009	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Alcohol Research Center Grants	000	14	12/7/2009	NON-COMPETING CONTINUATION	$171,283
2010	2009	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Center Grants	001	14	12/7/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,866,999

Issue Date FY: 2009 ( Subtotal = $1,780,303 ) (Continued on the next page)
Grand Total All Awards = $47,206,612

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Alcohol Research Center - Treatment and Implications

Award Number: P50AA010761

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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