Thursday, November 21, 2024 11/21/2024

The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous Chemicals

Award Number: P42ES027707
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT – OVERALL N-Nitrosamines are a family of hazardous chemicals that are among the most mutagenic chemicals known, and many are potently carcinogenic in animal models. People living in Wilmington, MA, are concerned about N- nitrosamines because there are over 20 million gallons of N-nitrosamine-contaminated waste at the nearby Olin Chemical Superfund Site, contaminating the environment and rendering their well water undrinkable. The Passamaquoddy Tribe is also concerned about N-nitrosamines, because their water contains high levels of organic material and the use of chloramine is known to create N-nitrosodimethylamine. Specific Aim 1 is to make and measure. Innovative, light-based chemical sensors that exploit smartphones will be created and used for Citizen Science to gain information that will help to inform cleanup by the Environmental Protection Agency (EPA). Innovative, high-throughput `animate sensors,' based on cell-microarray technology, will be created and used to test the consequences of N-nitrosamines on health-related impacts known to be associated with cancer risk. To understand disease more deeply, a genetically engineered “canary in the coal mine” mouse model will be used to reveal the potential for long-term low-dose exposure to cause mutations and deleterious biological responses. Specific Aim 2 is to protect human health via prediction and prevention of disease. By integrating multi-omics data (fueled by the Data Management and Analysis Core [DMAC]), mechanistic knowledge will propel the development of predictive biomarkers that can be used to develop methods to prevent disease. The potential for probiotics to suppress N-nitrosamine-induced cancer will be studied. In addition, novel devices will be created to destroy N-nitrosamines via electrochemical and biochemical destruction. Importantly, risk evaluation depends on knowledge from both engineers and biologists. The DMAC will thus form a critical integrating role by merging transdisciplinary data streams to evaluate risk for specific water samples. Specific Aim 3 is to maximize societal impact via integration within the MIT SRP and with partners outside of MIT. Partnering with the community will allow collection of environmental data that will inform risk. Via bidirectional communication, community members will also benefit from novel, hands-on teaching kits, while MIT SRP members will benefit from learning about community perspectives and concerns. Dissemination of MIT SRP knowledge and technologies will also be achieved via continued strengthening of relationships between the MIT SRP and local, state, Tribal and governmental agents, including community members who are most impacted by N-nitrosamine contamination. All of this work will be made possible by careful coordination and formalization of translation opportunities (made possible by the Administrative Core), and by continuous improvement of training opportunities that not only fuel the research (made possible by the Research Experience and Training Coordination Core [RETCC]), but also help to ensure that trainees go on to contribute as responsible leaders who are able to leverage cross-disciplinary research in order to have a powerful impact on public health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,238,751 )
2024	2024	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	8	7/22/2024	NON-COMPETING CONTINUATION	$0
2024	2024	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	8	6/27/2024	NON-COMPETING CONTINUATION	$2,238,751
2024	2024	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	8	8/16/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,238,751

Issue Date FY: 2023 ( Subtotal = $2,276,229 )
2023	2023	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	7	6/15/2023	NON-COMPETING CONTINUATION	$2,276,229
2023	2022	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	6	3/13/2023	COMPETING CONTINUATION	$390,469
2023	2021	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	3/13/2023	NON-COMPETING CONTINUATION	-$390,469
														Subtotal = $2,276,229

Issue Date FY: 2022 ( Subtotal = $2,250,284 )
2022	2022	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	6	8/22/2022	COMPETING CONTINUATION	$2,250,284
2022	2021	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	3/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,250,284

Issue Date FY: 2021 ( Subtotal = $1,508,268 )
2021	2021	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	5	3/24/2021	NON-COMPETING CONTINUATION	$0
2021	2021	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	5	5/27/2021	SUPPLEMENT FOR EXPANSION	$43,079
2021	2021	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	5	3/18/2021	NON-COMPETING CONTINUATION	$1,465,189
2021	2020	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	4	2/12/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,508,268

Issue Date FY: 2020 ( Subtotal = $1,558,104 )
2020	2020	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	4	7/17/2020	SUPPLEMENT FOR EXPANSION	$33,332
2020	2020	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	4	7/15/2020	SUPPLEMENT FOR EXPANSION	$222,490
2020	2020	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	4	4/15/2020	NON-COMPETING CONTINUATION	$1,291,482
2020	2020	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	4	6/29/2020	SUPPLEMENT FOR EXPANSION	$10,800
2020	2019	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	3	12/13/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,558,104

Issue Date FY: 2019 ( Subtotal = $1,791,137 )
2019	2019	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	3	4/29/2019	NON-COMPETING CONTINUATION	$1,299,085
2019	2019	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	3	5/2/2019	NON-COMPETING CONTINUATION	$0
2019	2019	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	3	9/11/2019	SUPPLEMENT FOR EXPANSION	$492,052
2019	2019	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	3	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	12/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,791,137

Issue Date FY: 2018 ( Subtotal = $1,288,766 )
2018	2018	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	3/28/2018	NON-COMPETING CONTINUATION	$1,288,766
														Subtotal = $1,288,766

Issue Date FY: 2017 ( Subtotal = $1,258,950 )
2017	2017	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	1	8/31/2017	NEW	$1,258,950
														Subtotal = $1,258,950

Grand Total All Awards = $14,170,489

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The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous Chemicals

Award Number: P42ES027707

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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