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DETECTION AND MODELS OF TOXICANT EXPOSURE

Award Number: P42ES010337
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2000
PERIOD OF PERFORMANCE END DATE: 03/31/2024

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DETECTION AND MODELS OF TOXICANT EXPOSURE - Center Summary/Abstract Nonalcoholic fatty liver disease (NAFLD) is escalating in California and the United States and is associated with the rising obesity epidemic. NAFLD is a hepatic phenotype that encompasses the more serious manifestation of steatohepatitis (NASH), considered to be a prerequisite for liver cancer (hepatocellular carcinoma/HCC). We also know from recent clinical studies that chemical toxicant exposure, in the absence of obesity, can lead to toxicant-associated steatohepatitis (TASH), which closely resembles the pathology of NASH. These findings are relevant to SRP stakeholders in Region 9, since California ranks high in National Priorities List (Superfund sites) nationally and contains thousands of additional hazardous waste sites (HWS). In addition, the UCSD NAFLD Research Center shows that American Indians and Hispanics, combined the largest non-Caucasian population in California, are at far greater risk of developing NAFLD. Over the past five years, our SRC has leveraged resources to demonstrate that TASH is greatly accelerated by consumption of high-fat diet (HFD) or after a diabetic episode in mice. These findings are relevant, since we can speculate that American Indians and Hispanics are more susceptible to TASH development, a risk amplified by unhealthy diets, poverty and health disparities. The UCSD SRC will be developing models through its Biomedical projects to characterize the mechanisms of Superfund toxicant induced TASH development and cancer, while the Environmental Science & Engineering (ES&E) projects will develop tools for NPL-toxicant detection and remediation. Biomedical and ES&E projects will be assisted in these efforts by Research Core services that will provide tools for mouse genetic production, metabolomic and sophisticated Bioinformatic analysis. A key objective of the projects is to highlight scientific findings to maximize Research Translation, which will happen with collaborations between the projects and the Research Translation Core. We believe our program is innovative and paradigm shifting, since it has the potential of linking important basic research findings regarding Superfund toxicant exposure with human disease biomarker identification through collaborations with the UCSD NAFLD Research Center, which contains one of the largest NALFD cohort studies in the world. Importantly, our Biomedical findings and tools developed in the ES&E projects will be used as resources and knowledge gained to reduce cumulative impacts and health disparities. These initiatives will be leveraged through Community Engagement Core efforts in disadvantaged Hispanic neighborhoods in San Diego and Mexico where statistics confirms that obesity is an escalating problem both in children and adults. Since the incidence of NAFLD and liver cirrhosis is on the rise in both children and adults and may be linked to toxicant chemical exposure, our findings will be communicated to SRP primary stakeholders at the U.S. Environmental Protection Agency and the Agency for Toxic Substances and Disease Registry, in addition to state and local agencies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Trans-NIH Research Support	000	20	8/13/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	20	8/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Trans-NIH Research Support	001	20	3/29/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	20	3/28/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $1,193,908 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Trans-NIH Research Support	003	20	6/23/2022	SUPPLEMENT FOR EXPANSION	$1,193,908
2022	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	20	9/20/2022	NON-COMPETING CONTINUATION	$0
2022	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Trans-NIH Research Support	001	19	1/31/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Trans-NIH Research Support	000	19	11/23/2021	SUPPLEMENT FOR EXPANSION	$0
2022	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Trans-NIH Research Support	002	19	4/1/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,193,908

Issue Date FY: 2021 ( Subtotal = $2,634,787 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	20	4/23/2021	NON-COMPETING CONTINUATION	$2,634,787
2021	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Trans-NIH Research Support	001	19	5/3/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,634,787

Issue Date FY: 2020 ( Subtotal = $6,532,444 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	19	4/3/2020	NON-COMPETING CONTINUATION	$2,363,608
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Trans-NIH Research Support	003	19	9/24/2020	SUPPLEMENT FOR EXPANSION	$3,759,967
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	19	9/15/2020	SUPPLEMENT FOR EXPANSION	$408,869
2020	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	18	1/22/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,532,444

Issue Date FY: 2019 ( Subtotal = $3,130,746 )
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	18	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	18	3/29/2019	NON-COMPETING CONTINUATION	$2,415,449
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	18	9/12/2019	SUPPLEMENT FOR EXPANSION	$715,297
2019	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	17	12/10/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,130,746

Issue Date FY: 2018 ( Subtotal = $2,465,449 )
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	17	4/17/2018	NON-COMPETING CONTINUATION	$2,415,449
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	16	12/22/2017	SUPPLEMENT FOR EXPANSION	$50,000
2018	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	16	11/17/2017	COMPETING CONTINUATION	$196,824
2018	2016	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	11/17/2017	EXTENSION WITH OR WITHOUT FUNDS	-$196,824
														Subtotal = $2,465,449

Issue Date FY: 2017 ( Subtotal = $2,379,199 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	16	6/30/2017	COMPETING CONTINUATION	$2,379,199
2017	2016	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	1/23/2017	EXTENSION WITH OR WITHOUT FUNDS	-$2,952,970
2017	2016	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	15	1/23/2017	EXTENSION WITH OR WITHOUT FUNDS	$2,952,970
2017	2016	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	15	6/27/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $2,379,199

Issue Date FY: 2016 ( Subtotal = $2,952,970 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	3/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,952,970
2016	2016	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	15	9/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $2,952,970

Issue Date FY: 2015 ( Subtotal = $3,062,142 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	14	3/31/2015	NON-COMPETING CONTINUATION	$3,062,142
														Subtotal = $3,062,142

Issue Date FY: 2014 ( Subtotal = $2,978,828 )
2014	2014	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	13	4/7/2014	NON-COMPETING CONTINUATION	$2,978,828
														Subtotal = $2,978,828

Issue Date FY: 2013 ( Subtotal = $2,920,643 )
2013	2013	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	12	6/26/2013	NON-COMPETING CONTINUATION	$474,030
2013	2013	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	12	5/7/2013	NON-COMPETING CONTINUATION	$2,446,613
														Subtotal = $2,920,643

Issue Date FY: 2012 ( Subtotal = $3,069,860 )
2012	2012	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	11	4/26/2012	COMPETING CONTINUATION	$3,069,860
														Subtotal = $3,069,860

Issue Date FY: 2011 ( Subtotal = $150,000 )
2011	2011	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	10	8/8/2011	SUPPLEMENT FOR EXPANSION	$150,000
														Subtotal = $150,000

Issue Date FY: 2010 ( Subtotal = $3,208,819 ) (Continued on the next page)
Grand Total All Awards = $69,849,788

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DETECTION AND MODELS OF TOXICANT EXPOSURE

Award Number: P42ES010337

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2000

PERIOD OF PERFORMANCE END DATE: 03/31/2024

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