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NATIONAL FLOW CYTOMETRY AND SORTING RESEARCH RESOURCE

Award Number: P41RR001315
ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/26/1997
PERIOD OF PERFORMANCE END DATE: 03/31/2012

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NATIONAL FLOW CYTOMETRY AND SORTING RESEARCH RESOURCE - DESCRIPTION (provided by the applicant): The NIH Roadmap Initiative has as one of its key underlying objectives the implementation of high through put, multiplexed instruments for application in a wide variety of basic and clinical research. The flow cytometry platform is ideally suited to this purpose, and several recent technologies have significantly increased throughput and simultaneous, multiparametric analysis. We propose to provide several critical technology advances by extending the capabilities and applications of flow-based analysis and sorting to produce an increasingly multiparameter, high-throughput analysis and screening tool. This will be accomplished through an integrated plan of three Research and Development Projects, extensive internal and external Collaborations, a wide variety of Service projects, expansion of our Training efforts, and increased Dissemination activities. The R&D Projects aim to extend flow cytometry into three areas of direct relevance to the Roadmap goals: 1) application of acoustic focusing and sensing technology to provide both novel analysis parameters and in-line sample preparation; 2) increasing both the throughput and the particle size range of flow sorting technologies; and 3) developing an integrated instrument to collect complete emission spectra separated according to fluorescence lifetime. Each of these projects has a defined set of collaborations that apply the new technologies to a wide range of biomedical research, including protein engineering, protein-protein interactions, drug and ligand screening, multiplexed cellular analysis, and automated preparation and analysis of complex clinical and environmental samples. In addition, we will continue and expand our Collaborative projects using instruments developed in the previous funding period. We will expand our Service efforts by providing access to a wide variety of commercial and unique developmental instruments. We will continue our traditionally outstanding Training program of hands-on courses and student/PostDoc mentorship, and develop new courses focused on application of our recent technology advances. Our strong Dissemination program will also be extended to include an improved website and the sponsorship of three focused meetings on various aspects of advanced flow cytometry. In conclusion, we propose to continue to drive the design, development, and application of flow cytometry technology as a multiplexed, high-throughput platform for advanced biomedical and clinical research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $1,178,850 )
2011	2011	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	National Center for Research Resources	002	30	8/15/2011	NON-COMPETING CONTINUATION	-$572,650
2011	2011	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	National Center for Research Resources	003	30	9/5/2011	NON-COMPETING CONTINUATION	$107,430
2011	2011	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	National Center for Research Resources	001	30	4/15/2011	SUPPLEMENT FOR EXPANSION	$63,331
2011	2011	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	National Center for Research Resources	000	30	4/8/2011	NON-COMPETING CONTINUATION	$1,580,739
														Subtotal = $1,178,850

Issue Date FY: 2010 ( Subtotal = $1,705,221 )
2010	2010	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	National Center for Research Resources	000	29	3/31/2010	NON-COMPETING CONTINUATION	$1,705,221
														Subtotal = $1,705,221

Issue Date FY: 2009 ( Subtotal = $1,655,554 )
2009	2009	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	National Center for Research Resources	000	28	4/8/2009	NON-COMPETING CONTINUATION	$1,655,554
														Subtotal = $1,655,554

Issue Date FY: 2008 ( Subtotal = $1,687,843 )
2008	2008	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	National Center for Research Resources	000	27	8/22/2008	NON-COMPETING CONTINUATION	$1,687,843
														Subtotal = $1,687,843

Issue Date FY: 2007 ( Subtotal = $2,151,366 )
2007	2007	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	National Center for Research Resources	000	26	9/27/2007	COMPETING CONTINUATION	$2,151,366
														Subtotal = $2,151,366

Issue Date FY: 2006 ( Subtotal = $1,592,366 )
2006	2006	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	National Center for Research Resources	000	25	9/27/2006	NON-COMPETING CONTINUATION	$1,592,366
														Subtotal = $1,592,366

Issue Date FY: 2005 ( Subtotal = $1,654,470 )
2005	2005	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	National Center for Research Resources	000	23	7/26/2005	NON-COMPETING CONTINUATION	$1,654,470
														Subtotal = $1,654,470

Issue Date FY: 2004 ( Subtotal = $1,623,520 )
2004	2004	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	National Center for Research Resources	000	22	7/23/2004	NON-COMPETING CONTINUATION	$1,623,520
														Subtotal = $1,623,520

Issue Date FY: 2003 ( Subtotal = $1,434,937 )
2003	2003	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	National Center for Research Resources	000	21	7/31/2003	NON-COMPETING CONTINUATION	$1,434,937
														Subtotal = $1,434,937

Issue Date FY: 2002 ( Subtotal = $1,621,475 )
2002	2002	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Biomedical Technology	000	20	9/30/2002	COMPETING CONTINUATION	$1,621,475
														Subtotal = $1,621,475

Issue Date FY: 2001 ( Subtotal = $1,471,942 )
2001	2001	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Biomedical Technology	000	19	7/3/2001	NON-COMPETING CONTINUATION	$1,471,942
														Subtotal = $1,471,942

Issue Date FY: 2000 ( Subtotal = $1,422,853 )
2000	2000	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Biomedical Technology	000	18	7/7/2000	NON-COMPETING CONTINUATION	$1,422,853
														Subtotal = $1,422,853

Issue Date FY: 1999 ( Subtotal = $1,532,312 )
1999	1999	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Biomedical Technology	000	17	6/18/1999	NON-COMPETING CONTINUATION	$1,532,312
														Subtotal = $1,532,312

Issue Date FY: 1998 ( Subtotal = $1,191,367 )
1998	1998	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Biomedical Technology	000	16	8/14/1998	NON-COMPETING CONTINUATION	$1,146,333
1998	1998	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Biomedical Technology	001	16	9/30/1998	SUPPLEMENT FOR EXPANSION	$45,034
														Subtotal = $1,191,367

Grand Total All Awards = $21,924,076

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NATIONAL FLOW CYTOMETRY AND SORTING RESEARCH RESOURCE

Award Number: P41RR001315

ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/26/1997

PERIOD OF PERFORMANCE END DATE: 03/31/2012

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