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Center on Macromolecular Dynamics by NMR Spectroscopy

Award Number: P41GM118302
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2022

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Center on Macromolecular Dynamics by NMR Spectroscopy - This proposal describes the need for and outline of a Biomedical Technology Research Resource entitled Center on Macromolecular Dynamics by NMR Spectroscopy (CoMD/NMR) and situated at the New York Structural Biology Center. The focus of CoMD/NMR is technical development and application of NMR spin relaxation and associated methods for characterizing protein and nucleic acid conformational dynamics in biological processes including ligand recognition, allosterism, catalysis, and folding. The central challenge addressed by CoMD/NMR is to break down the high activation barrier to using advanced NMR spectroscopic and computational methods and thus to make available the benefits of these sophisticated approaches to the wider biological research community. CoMD/NMR is the platform for meeting this challenge through Technological Research and Development (TR&D) Projects, Driving Biomedical Projects (DBPs), Collaboration and Service, Training, and Dissemination components of the Resource. The TR&D component of CoMD/NMR will develop new and extended methods for characterizing and interpreting macromolecular dynamics, with a strong focus on expanding the general ranges of time scales and masses of targets accessible for study. The dual needs for integrating experimental, computational, and theoretical methods (within the TR&D component) and for interfacing with key biological researchers (within the DBP and Collaboration components) make CoMD/NMR essential. In particular, CoMD/NMR addresses four primary obstacles: (i) future technology developments requires combined advances in sample preparation, NMR hardware and methods development, and integration with computer methods; (ii) access to NMR spectrometers at multiple static magnetic fields, as well as specialty equipment such as dynamic nuclear polarization and field cycling probes, is key to many emerging methods; (iii) transfer of technology to the general biological community has been hindered by the complexity of the methods, absence of integrated pipelines to facilitate data acquisition and analysis by non- specialists, and lack of infrastructure in individual laboratories to translate these methods for general use; and (iv) biologists with research programs that would benefit from these methods are unaware of this potential and lack expertise to incorporate these approaches into their own research. Technology development proceeds most effectively when driven by challenging applications; accordingly, CoMD/NMR will work closely with outstanding local and national investigators in DBPs designed to motivate and test emerging technology. The resources of CoMD/NMR will be broadly available to the biomedical research community through collaboration and service activities together with expansive training and dissemination programs. The basic research developments of CoMD/NMR will impact a diverse range of biological research with human health relatedness, including degenerative diseases, metabolic disorders, and cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	THE NEW YORK STRUCTURAL BIOLOGY CENTER, INC.	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	5	1/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	5	3/9/2022	NON-COMPETING CONTINUATION	$0
2022	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	5	6/16/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $1,723,201 )
2021	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	002	5	7/28/2021	SUPPLEMENT FOR EXPANSION	$475,380
2021	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	5	6/11/2021	NON-COMPETING CONTINUATION	$1,247,821
2021	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	003	5	8/2/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	4	12/22/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,723,201

Issue Date FY: 2020 ( Subtotal = $1,250,482 )
2020	2020	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	4	6/16/2020	NON-COMPETING CONTINUATION	$1,250,482
2020	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	3	11/5/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,250,482

Issue Date FY: 2019 ( Subtotal = $1,537,381 )
2019	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	3	7/30/2019	SUPPLEMENT FOR EXPANSION	$278,041
2019	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	3	6/27/2019	NON-COMPETING CONTINUATION	$1,259,340
														Subtotal = $1,537,381

Issue Date FY: 2018 ( Subtotal = $2,072,728 )
2018	2018	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	2	6/4/2018	NON-COMPETING CONTINUATION	$1,272,728
2018	2018	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	2	8/24/2018	SUPPLEMENT FOR EXPANSION	$800,000
														Subtotal = $2,072,728

Issue Date FY: 2017 ( Subtotal = $1,958,909 )
2017	2017	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	1	5/25/2017	NEW	$1,958,909
														Subtotal = $1,958,909

Grand Total All Awards = $8,542,701

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Center on Macromolecular Dynamics by NMR Spectroscopy

Award Number: P41GM118302

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2022

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