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Center on Membrane Protein Production and Analysis (COMPPAA)

Award Number: P41GM116799
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2016
PERIOD OF PERFORMANCE END DATE: 04/30/2022

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Center on Membrane Protein Production and Analysis (COMPPAA) - DESCRIPTION (provided by applicant): Proteins in membranes provide the portals through which membrane-delimited organelles within cells and cells themselves communicate with their external environments. These essential properties make membrane proteins crucial components in biochemistry and in cell biology. Many membrane proteins are involved in processes of disease, and they are the molecular targets of over 40% of all FDA-approved drugs. Atomic level structure informs both biochemical understanding and drug discovery. Yet, whereas membrane proteins constitute 20-30% of all proteins in all of life, results from membrane proteins comprise only 1.6% of atomic structures in the Protein Data Bank. To a large extent, this structural under-representation arises because of the challenges in producing and analyzing membrane protein structure and function. New technology is needed to address these challenges. We propose to develop the Center on Membrane Protein Production and Analysis (COMPPAA, or COMPPÅ for short) as a Biomedical Technology Research Resource (BTRR) for the production and study of membrane proteins of relevance to biology and medicine. We will build on existing facilities and talents at the New York Structural Biology Center (NYSBC), which include capabilities for structure determination by x-ray crystallography, cryo-electron microscopy (cryo-EM) and NMR spectroscopy as well as a facility for high-throughput expression testing and detergent screening for membrane proteins. COMPPÅ will have nine components including four Technology Research and Development (TR&D) projects which will be driven by Driving Biomedical Project (DBP) component that will comprise fifteen selected DBPs to serve as test beds for the TR&D development. TR&D1 will develop technology for the efficient production of recombinant membrane proteins. TR&D2 will develop technology for the optimization of membrane protein samples for structural analysis. TR&D3 will develop generic assays for functional analy


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	THE NEW YORK STRUCTURAL BIOLOGY CENTER, INC.	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	5	10/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $1,295,000 )
2020	2020	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	5	6/8/2020	NON-COMPETING CONTINUATION	$1,295,000
2020	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	4	11/4/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,295,000

Issue Date FY: 2019 ( Subtotal = $1,445,000 )
2019	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	4	5/31/2019	NON-COMPETING CONTINUATION	$1,295,000
2019	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	002	4	8/6/2019	SUPPLEMENT FOR EXPANSION	$150,000
2019	2018	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	3	12/4/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,445,000

Issue Date FY: 2018 ( Subtotal = $1,365,234 )
2018	2018	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	3	8/27/2018	SUPPLEMENT FOR EXPANSION	$25,190
2018	2018	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	3	5/23/2018	NON-COMPETING CONTINUATION	$1,340,044
														Subtotal = $1,365,234

Issue Date FY: 2017 ( Subtotal = $1,442,059 )
2017	2017	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	2	6/8/2017	NON-COMPETING CONTINUATION	$144,206
2017	2017	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	2	4/27/2017	NON-COMPETING CONTINUATION	$1,297,853
														Subtotal = $1,442,059

Issue Date FY: 2016 ( Subtotal = $1,519,905 )
2016	2016	NEW YORK STRUCTURAL BIOLOGY CENTER	89 CONVENT AVE PARK BLDG	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	1	5/1/2016	NEW	$1,519,905
														Subtotal = $1,519,905

Grand Total All Awards = $7,067,198

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Center on Membrane Protein Production and Analysis (COMPPAA)

Award Number: P41GM116799

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2016

PERIOD OF PERFORMANCE END DATE: 04/30/2022

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