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Imaging Mass Spectrometry Research Resource at Vanderbilt University

Award Number: P41GM103391
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2011
PERIOD OF PERFORMANCE END DATE: 12/31/2021

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Imaging Mass Spectrometry Research Resource at Vanderbilt University - DESCRIPTION (PROVIDED BY APPLICANT): We propose to renew funding for the National Research Resource for Imaging Mass Spectrometry (IMS) at Vanderbilt University School of Medicine, Nashville TN. The previous funding cycle has been extremely successful in both advancing IMS technology and applying it to cutting edge biological projects. In this renewal, we seek to advance the technology to provide next generation capabilities that will encompass sub-micron spatial resolution, ultra-high sensitivity, and ease of use tools that will be made availabl to the non-expert investigator. This proposal contains two overarching aims. First, it proposes to pioneer novel instrument technologies, sample preparation devices and methods, and data analysis/image informatics solutions. The latter is a critical need for current research grade IMS instrumentation, and it will be essential for next-generation instruments.. Second, this proposal seeks to simplify the entire imaging process that currently requires expertise and significant time to get high quality, meaningful results. Achievement of these global aims is important to bring this technology into the biological and clinical laboratory. The proposed Technology Research & Development (TRD) program will provide performance improvements that will meet many of the current needs of the user community. Specific TRD advancements will focus on maximizing instrument sensitivity and spatial resolution. We will also develop specialty reagents and methodologies designed to enhance sensitivity, molecular specificity, and preserve the location of biomolecules during sample preparation and analysis. We propose to develop a next generation imaging mass spectrometer for routine use that is capable of achieving 500 nm spatial resolution at high sensitivity. Additionally, we will develop software capable of co-registering and viewing imaging data from multiple modalities such as IMS and microscopy through an image fusion process. Finally, we will develop new advanced bio-computational algorithms to mine imaging data for molecular patterns and to normalize images from large datasets. These developing advanced technologies will be focused on important driving biomedical projects (DBPs) in infectious disease, eye disease, diabetes, and cancer. Important activities of the Resource include: selected collaborations with investigators who have NIH sponsored research projects that would significantly benefit from the developing IMS technology. This includes high spatial resolution imaging, high mass resolving power instrumentation and advanced data analysis and informatics capabilities. Training and dissemination of the technology will continue to be accomplished through a yearly on-site four day training course termed AIMS (Advanced Imaging Mass Spectrometry). In addition, training and dissemination will occur through hosting individual visiting investigators, students, and fellows, and through publication of the research outcomes for both the technology and its applications, and from individual invited research lectures presented by the faculty of the Resource.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $13,241 )
2023	2020	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Biomedical Research and Research Training	000	10	11/23/2022	NON-COMPETING CONTINUATION	$13,241
														Subtotal = $13,241

Issue Date FY: 2022 ( Subtotal = -$387,258 )
2022	2020	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Biomedical Research and Research Training	000	10	7/26/2022	NON-COMPETING CONTINUATION	-$387,258
														Subtotal = -$387,258

Issue Date FY: 2020 ( Subtotal = $1,840,353 )
2020	2020	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Biomedical Research and Research Training	000	10	2/3/2020	NON-COMPETING CONTINUATION	$1,656,317
2020	2020	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Biomedical Research and Research Training	001	10	3/10/2020	NON-COMPETING CONTINUATION	$184,036
														Subtotal = $1,840,353

Issue Date FY: 2019 ( Subtotal = $1,923,696 )
2019	2019	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Biomedical Research and Research Training	000	9	12/24/2018	NON-COMPETING CONTINUATION	$1,923,696
														Subtotal = $1,923,696

Issue Date FY: 2018 ( Subtotal = $2,116,784 )
2018	2018	VANDERBILT UNIVERSITY, THE	2301 VANDERBILT PL	NASHVILLE	TN	37235	DAVIDSON	USA	Biomedical Research and Research Training	001	8	4/25/2018	NON-COMPETING CONTINUATION	$211,679
2018	2018	VANDERBILT UNIVERSITY, THE	211 KIRKLAND HALL	NASHVILLE	TN	37240	DAVIDSON	USA	Biomedical Research and Research Training	000	8	12/29/2017	NON-COMPETING CONTINUATION	$1,905,105
														Subtotal = $2,116,784

Issue Date FY: 2017 ( Subtotal = $2,158,001 )
2017	2017	VANDERBILT UNIVERSITY, THE	211 KIRKLAND HALL	NASHVILLE	TN	37240	DAVIDSON	USA	Biomedical Research and Research Training	003	7	6/8/2017	NON-COMPETING CONTINUATION	$215,801
2017	2017	VANDERBILT UNIVERSITY, THE	211 KIRKLAND HALL	NASHVILLE	TN	37240	DAVIDSON	USA	Biomedical Research and Research Training	002	7	1/25/2017	NON-COMPETING CONTINUATION	$1,942,200
2017	2016	VANDERBILT UNIVERSITY, THE	211 KIRKLAND HALL	NASHVILLE	TN	37240	DAVIDSON	USA	Biomedical Research and Research Training	001	6	12/19/2016	COMPETING CONTINUATION	$373,203
2017	2015	VANDERBILT UNIVERSITY, THE	211 KIRKLAND HALL	NASHVILLE	TN	37240	DAVIDSON	USA	Biomedical Research and Research Training	000	5	12/19/2016	NON-COMPETING CONTINUATION	-$373,203
														Subtotal = $2,158,001

Issue Date FY: 2016 ( Subtotal = $2,427,094 )
2016	2016	VANDERBILT UNIVERSITY	3319 WEST END AVENUE SUITE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Biomedical Research and Research Training	001	6	6/14/2016	COMPETING CONTINUATION	$2,427,094
2016	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Biomedical Research and Research Training	000	5	6/10/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,427,094

Issue Date FY: 2015 ( Subtotal = $1,726,817 )
2015	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Biomedical Research and Research Training	000	5	1/2/2015	NON-COMPETING CONTINUATION	$1,726,817
														Subtotal = $1,726,817

Issue Date FY: 2014 ( Subtotal = $1,723,507 )
2014	2014	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Biomedical Research and Research Training	000	4	1/10/2014	NON-COMPETING CONTINUATION	$1,627,753
2014	2014	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Biomedical Research and Research Training	001	4	2/24/2014	NON-COMPETING CONTINUATION	$95,754
														Subtotal = $1,723,507

Issue Date FY: 2013 ( Subtotal = $1,847,655 )
2013	2013	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Biomedical Research and Research Training	001	3	6/4/2013	NON-COMPETING CONTINUATION	$124,453
2013	2013	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Biomedical Research and Research Training	000	3	12/26/2012	NON-COMPETING CONTINUATION	$1,723,202
														Subtotal = $1,847,655

Issue Date FY: 2012 ( Subtotal = $1,906,854 )
2012	2012	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Biomedical Research and Research Training	000	2	3/1/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,906,854
														Subtotal = $1,906,854

Grand Total All Awards = $17,296,744

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Imaging Mass Spectrometry Research Resource at Vanderbilt University

Award Number: P41GM103391

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2011

PERIOD OF PERFORMANCE END DATE: 12/31/2021

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